I listen to several Podcasts; using smartlists to identiy partly played casts and those I haven't started.
That won't be possible come iOS 6:
...In iOS 6, the Music app removes podcasts altogether ...
Leaving us with the crummy Podcast.app.
We've also been told to expect an iTunes update. I wonder if that will drop podcasts too. I expect smart lists to go. We already know iOS 6 will lose Google Maps.
For me iOS 6 and iTunes 11 look to be big regressions. iPhone 5 and it's new cable hasn't impressed me either. I'll be going slow on both, which means I'll likely defer my iPhone 5 too.