Monday, March 01, 2004

Seymour Hersh (New Yorker) The spring offensive for bin Laden, and the nuclear chasm opening up ...

The New Yorker

This Hersh article may explain a few things, including why the military is more confident about getting bin Laden, and why bin Laden's rumored to have fled Pakistan for Afghanistan. Bin Laden aside, the nuclear black market story is going from big to unprecedented, with astonishingly little popular excitement. This may be one of those "I really prefer not to know" situations for most Americans. As I've noted before, the Malaysian connection is extremely interesting and very scary. They have the technology to do miniaturized bombs.

The spring offensive has been rumored for months. It sounds bigger all the time; it may be driving the hurried exit from Iraq almost as much as Bush's reelection campaign. Of course Iraq was supposed to have been such a cakewalk that our forces were to have been freed up last year and rested by now.

As with all Hersh exclusives, one wonders who in the CIA is leaking this and why ... How much is real and how much deception ...

Emphases mine. Note bin Laden's goatherds are now all dead.
THE DEAL by SEYMOUR M. HERSH - The New Yorker
Why is Washington going easy on Pakistan’s nuclear black marketers?
Issue of 2004-03-08
Posted 2004-03-01

On February 4th, Dr. Abdul Qadeer Khan, who is revered in Pakistan as the father of the country’s nuclear bomb, appeared on a state-run television network in Islamabad and confessed that he had been solely responsible for operating an international black market in nuclear-weapons materials. His confession was accepted by a stony-faced Pervez Musharraf, Pakistan’s President, who is a former Army general, and who dressed for the occasion in commando fatigues. The next day, on television again, Musharraf, who claimed to be shocked by Khan’s misdeeds, nonetheless pardoned him, citing his service to Pakistan (he called Khan "my hero"). Musharraf told the Times that he had received a specific accounting of Khan’s activities in Iran, North Korea, and Malaysia from the United States only last October. If they knew earlier, they should have told us, he said. Maybe a lot of things would not have happened.

It was a make-believe performance in a make-believe capital. In interviews last month in Islamabad, a planned city built four decades ago, politicians, diplomats, and nuclear experts dismissed the Khan confession and the Musharraf pardon with expressions of scorn and disbelief. For two decades, journalists and American and European intelligence agencies have linked Khan and the Pakistani intelligence service, the I.S.I. (Inter-Service Intelligence), to nuclear-technology transfers...

A Bush Administration intelligence officer with years of experience in nonproliferation issues told me last month, One thing we do know is that this was not a rogue operation...The intelligence officer went on, We had every opportunity to put a stop to the A. Q. Khan network fifteen years ago. Some of those involved today in the smuggling are the children of those we knew about in the eighties. It’s the second generation now.

...Musharraf, who seized power in a coup d’état in 1999, has been a major ally of the Bush Administration in the war on terrorism. According to past and present military and intelligence officials, however, Washington’s support for the pardon of Khan was predicated on what Musharraf has agreed to do next: look the other way as the U.S. hunts for Osama bin Laden in a tribal area of northwest Pakistan dominated by the forbidding Hindu Kush mountain range, where he is believed to be operating...

Musharraf has proffered other help as well. A former senior intelligence official said to me, Musharraf told us, ‘We’ve got guys inside. The people who provide fresh fruits and vegetables and herd the goats’ for bin Laden and his Al Qaeda followers. It’s a quid pro quo: we’re going to get our troops inside Pakistan in return for not forcing Musharraf to deal with Khan.

The spring offensive could diminish the tempo of American operations in Iraq. It’s going to be a full-court press, one Pentagon planner said. Some of the most highly skilled Special Forces units, such as Task Force 121, will be shifted from Iraq to Pakistan...

A large-scale American military presence in Pakistan could also create an uproar in the country and weaken Musharraf’s already tenuous hold on power. The operation represents a tremendous gamble for him personally (he narrowly survived two assassination attempts in December) and, by extension, for the Bush Administration -- if he fell, his successor might be far less friendly to the United States. One of Musharraf’s most vocal critics inside Pakistan is retired Army Lieutenant General Hamid Gul, a fundamentalist Muslim who directed the I.S.I. from 1987 to 1989, at the height of the Afghan war with the Soviets. If American troops start operating from Pakistan, there will be a rupture in the relationship, Gul told me. Americans think others are slaves to them. Referring to the furor over A. Q. Khan, he added, We may be in a jam, but we are a very honorable nation. We will not allow the American troops to come here. This will be the breaking point. If Musharraf has made an agreement about letting American troops operate in Pakistan, Gul said, he’s lying to you.

The greatest risk may be not to Musharraf, or to the stability of South Asia, but to the ability of the international nuclear monitoring institutions to do their work. Many experts fear that, with Khan’s help, the world has moved closer to a nuclear tipping point. Husain Haqqani, who was a special assistant to three prime ministers before Musharraf came to power and is a visiting scholar at the Carnegie Endowment for International Peace, noted, with some pride, that his nation had managed to make the bomb despite American sanctions. But now, he told me, Khan and his colleagues have gone wholesale: Once they had the bomb, they had a shopping list of what to buy and where. A. Q. Khan can bring a plain piece of paper and show me how to get it done -- the countries, people, and telephone numbers. ‘This is the guy in Russia who can get you small quantities of enriched uranium. You in Malaysia will manufacture the stuff. Here’s who will miniaturize the warhead. And then go to North Korea and get the damn missile.’ He added, This is not a few scientists pocketing money and getting rich. It’s a state policy.

... Last October, the Iranian government, after nine months of denials and obfuscation, and increasingly productive inspections, formally acknowledged to the I.A.E.A. that it had secretly been producing small quantities of enriched uranium and plutonium, and had been operating a pilot heavy-water reactor program, all potentially in violation of its obligations under the nuclear-nonproliferation treaty. Some of the secret programs, Iran admitted, dated back eighteen years...

... On a trip to the Middle East last month, I was told that a number of years ago the Israeli signals-intelligence agency, known as Unit 8200, broke a sophisticated Iranian code and began monitoring communications that included talk between Iran and Pakistan about Iran’s burgeoning nuclear-weapons program. The Israeli intelligence community has many covert contacts inside Iran, stemming from the strong ties it had there before the overthrow of the Shah, in 1979; some of these ties still exist...

The Israeli intercepts have been shared, in some form, with the United States intelligence community, according to the former senior intelligence official, and they show that high-level officials in Islamabad and Tehran had frequent conversations about the I.A.E.A. investigation and its implications. The interpretation is the issue here, the former official said. If you set the buzzwords aside, the substance is that the Iranians were saying, ‘We’ve got to play with the I.A.E.A. We don’t want to blow our cover, but we have to show some movement. There’s no way we’re going against world public opinion, no way. We’ve got to show that we’re coöperating and get the Europeans on our side.’ (At the time, Iran was engaged in negotiations with the European Union on trade and other issues.) It’s clear from the intercepts, however, the former intelligence official said, that Iran did not want to give up its nuclear potential. The Pakistani response, he added, was Don’t give away the whole ballgame and we’ll look out for you. There was a further message from Pakistan, the former official said: Look out for your own interests.

.. analysts throughout the American intelligence community, he said, are asking, How could it be that Pakistan’s done all these things,-- developed a second generation of miniaturized and boosted weapons -- and yet the investigation has been shorted to ground?

... Libya had been able to purchase hundreds of millions of dollars’ worth of nuclear parts, including advanced centrifuges designed in Pakistan, from a firm in Malaysia, with a free-trade zone in Dubai serving as the main shipping point. It was a new development in an old arms race: Malaysia, a high-tech nation with no indigenous nuclear ambitions, was retailing sophisticated nuclear gear, based on designs made available by Khan.

... I.A.E.A. inspectors, to their dismay, even found in Libya precise blueprints for the design and construction of a half-ton nuclear weapon. It’s a sweet little bomb, put together by engineers who know how to assemble a weapon, an official in Vienna told me. No question it’ll work. Just dig a hole and test it. It’s too big and too heavy for a Scud, but it’ll go into a family car. It’s a terrorist’s dream.

... One Arab intelligence operative told me that Libyan intelligence, with Qaddafi’s approval, then quickly offered to give American and British intelligence details about a centrifuge deal that was already under way. The parts were due to be shipped aboard a German freighter, the B.B.C. China. In October, the freighter was seized, and the incident was proclaimed a major intelligence success. But, the operative said, it was the Libyans who blew up the Pakistanis, and who made the role of Khan’s black market known. The Americans, he said, asked questions about those orders and Libya said it had them. It was, in essence, a sting, and was perceived that way by Musharraf. He was enraged by what he called, in a nationally televised speech last month, delivered in Urdu, and not officially translated by the Pakistani government, the betrayal of Pakistan by his Muslim brothers in both Libya and Iran. There was little loyalty between seller and buyer. The Pakistanis took a lot of Libya’s money and gave second-grade plans, the Arab intelligence operative said. It was halfhearted.

... There is a nuclear network of black-market centrifuges and weapons design that the world has yet to discover, a diplomat in Vienna told me. In the past, he said, the I.A.E.A. had worked under the assumption that nations would cheat on the nonproliferation treaty to produce and sell their own nuclear material. He said, What we have instead is a black-market network capable of producing usable nuclear materials and nuclear devices that is not limited to any one nation. We have nuclear dealers operating outside our front door, and we have no control over them...

This is a question of survival, the diplomat said, with a caustic smile. He added, Iraq is laughable in comparison with this issue. The Bush Administration was hunting the shadows instead of the prey.

Nonetheless, a senior Pentagon adviser told me in mid-February, the spring offensive is on...

The operation, American officials said, is scheduled to involve the redeployment to South Asia of thousands of American soldiers, including members of Task Force 121. The logistical buildup began in mid-February, as more than a dozen American C-17 cargo planes began daily flights, hauling helicopters, vehicles, and other equipment to military bases in Pakistan. Small teams of American Special Forces units have been stationed at the Shahbaz airbase, in northwestern Pakistan, since the beginning of the Afghanistan war, in the fall of 2001.

The senior Pentagon adviser, like other military and intelligence officials I talked to, was cautious about the chances of getting what the White House wants: Osama bin Laden. It’s anybody’s guess, he said, adding that Ops Sec (operational security) for the planned offensive was poor. The former senior intelligence official similarly noted that there was concern inside the Joint Special Operations Command, at Fort Bragg, North Carolina, over the reliability of intercepted Al Qaeda telephone calls. What about deception? he said. These guys are not dumb...

We’ve got to get Osama bin Laden, and we know where he is, the former senior intelligence official said. Osama bin Laden is communicating through sigint -- talking on satellite telephones and the like -- and his wings have been clipped. He’s in his own Alamo in northern Pakistan. It’s a natural progress -- whittling down alternative locations and then targeting him. This is not, in theory, a ‘Let’s go and hope’ kind of thing. They’ve seen what they think is him. But the former official added that there were reasons to be cautious about such reports, especially given that bin Laden hasn’t been seen for so long. Bin Laden would stand out because of his height; he is six feet five. But the target area is adjacent to Swat Valley, which is populated by a tribe of exceptionally tall people.

Two former C.I.A. operatives with firsthand knowledge of the Pakistan Afghanistan border areas said that the American assault, if it did take place, would confront enormous logistical problems. It’s impenetrable, said Robert Baer, who visited the Hindu Kush area in the early nineties, before he was assigned to lead the C.I.A.’s anti-Saddam operations in northern Iraq. There are no roads, and you can’t get armor up there. This is where Alexander the Great lost an entire division. The Russians didn’t even bother to go up there. Everybody’s got a gun. That area is worse than Iraq. Milton Bearden, who ran the C.I.A.’s operations in Afghanistan during the war with the Soviet Union, recounted, I’ve been all through there. The Pashtun population in that belt has lived there longer than almost any other ethnic group has lived anywhere on earth. He said, Our intelligence has got to be better than it’s been. Anytime we go into something driven entirely by electoral politics, it doesn’t work out.

One American intelligence consultant noted that American forces in Afghanistan have crossed into Pakistan in hot pursuit of Al Qaeda suspects in previous operations, with no complaints from the Pakistani leadership. If the American forces strike quickly and decisively against bin Laden from within Pakistan, he added, Musharraf could say he gave no advance authorization. We can move in with so much force and firepower -- with so much shock and awe -- that we will be too fast for him. The consultant said, The question is, how deep into Pakistan can we pursue him? He added, Musharraf is in a very tough position...

... Robert Gallucci, a former United Nations weapons inspector who is now dean of the Georgetown University School of Foreign Service, calls A. Q. Khan the Johnny Appleseed of the nuclear-arms race. Gallucci, who is a consultant to the C.I.A. on proliferation issues, told me, Bad as it is with Iran, North Korea, and Libya having nuclear-weapons material, the worst part is that they could transfer it to a non-state group. That’s the biggest concern, and the scariest thing about all this -- that Pakistan could work with the worst terrorist groups on earth to build nuclear weapons. There’s nothing more important than stopping terrorist groups from getting nuclear weapons. The most dangerous country for the United States now is Pakistan, and second is Iran. Gallucci went on, We haven’t been this vulnerable since the British burned Washington in 1814.

Stupid journalism:| Breast milk 'does cut heart risk'

BBC NEWS | Health | Breast milk 'does cut heart risk'
Breast-feeding does have a positive long-term effect on reducing blood pressure, research has suggested.

The study, by Bristol University, suggests that breast-fed babies grow up to have lower blood pressure than their bottle-fed counterparts.

If true, the finding, published in the journal Circulation, could mean breast-fed babies are less likely to develop heart disease.

I suspect the authors are somewht guilty, the journalist worse, and the headline writer worst of all. A typical pattern. This probably means absolutely nothing. Wake me up when they randomize the infants to bottle vs. breast then study them 20 years later.

Hyperlexia: an explanation of why we can read? (washingtonpost.com)

Studying Hyperlexia May Unlock How Brains Read (washingtonpost.com)
Understanding hyperlexia may also help explain how normal brains accomplish the feat of reading. Unlike seeing and hearing, skills acquired through evolution, reading is usually not acquired naturally. Humans have been reading for only a few thousand years, and the pressure for everyone to become good readers has become intense in only the past couple of centuries.

Reading involves a complex series of brain activities: Visual centers must first perceive variable, tiny features of printed symbols on a page, then those changes must be mentally converted into strings of sound, and finally the patterns of sound must be interpreted by language centers in the brain to register their meaning.

'Hyperlexia is the antithesis of dyslexia,' said Guinevere Eden, director of Georgetown University's Center for the Study of Learning, who has studied Alex. 'We spend all our time studying individuals who have a hard time learning to read, and here are these children who acquire reading in a spontaneous way. It's as if they know it already.'

Twenty years ago, when I first did a neuropsych course, I thought the "miracle of reading" was the most interesting question in human evolution. I guessed, as have many, that it developed from sign language. Indeed, if sign language preceded fluent verbalization, it may be that reading is more fundamental than speaking.

That would fit this story -- hyperlexic children often have difficulty with speech. We know from brain injured patients that speaking and reading abilities are likewise somewhat independent.

It would be very interesting to know how quickly hyperlexic children learn to sign, and whether there's a relationship in deaf children between signing ability and reading ability.

Saturday, February 28, 2004

Science fights back: Citizens for Science vs. the Discovery Institute

NYT: Montana Creationism Bid Evolves Into Unusual Fight

[Update May 2004]:

The June 2004 issue of Wired has an essay by Bruce Sterling on the societal disease of Lysenkoism. I'll try to remember to link to it when it's available online. Lysenkoism is what happens when political pseudoscience, as in evangelical biology, wins. Lysenkoism played an important role in the collapse of the old Soviet Empire. Same topic as this one. [EndUpdate]
In early December, a local Baptist minister, Curtis Brickley, put up handbills inviting residents of this town, population 754, to a meeting in the junior high school gym. The topic was the teaching of evolution in the Darby schools.

Two hundred people from Darby and surrounding Ravalli County, which nurtures a deep vein of conservative religious sentiment, filed into the gym on Dec. 10. There, the well-spoken minister delivered an elaborate PowerPoint presentation challenging Charles Darwin's theories.

There was nothing particularly unusual about Mr. Brickley's message. For years, opponents of evolutionary theory have been pressing their case, with similar arguments, in statehouses and school systems around the country. What was unusual was the response.

Within days, a group of parents, business people, teachers, students and other residents mobilized to defend Darwin against Mr. Brickley's challenge. The group, Ravalli County Citizens for Science, phoned a biotechnology firm in nearby Hamilton asking for help and was connected with Dr. Jay Evans, a research immunologist. He began looking into Mr. Brickley's claims, which were drawn in part from materials from the Discovery Institute, a Seattle-based organization affiliated with many conservative causes.

This is not a particularly well written article, but it appears the Citizens for Science movement started with the Kansas Chapter. Citizens for Science is state based, but the National Center for Science Education is, well, national.

Minnesota is following the path of Montana. Evangelical Republicans are moving on many fronts here to attack the models of natural selection and the theories of biological evolution. They are winning, but it is good to learn that a counter-attack is stirring. Of course if these Evangelicals really do manage to destroy science education, they'll also end up destroying the public school system as secular scholars move en masse to private schools.

Natural selection is one of the most powerful theories in the past two hundred years. It has been applied to a variety of systems, including political systems, economics, corporate behavior, and a very wide range of biological systems from the molecular level to the species level. It's even been applied to cosmology and the evolution of black holes.

Ironically, and this is the point that often gets missed, natural selction and Darwin's work are not inconsistent with "intelligent design". Indeed, were the universe designed, it's likely that the designer also experienced the effects of natural selection in action ...

The Russian nuclear fuel trade

Uranium Traveled to Iran Via Russia, Inspectors Find
In a report on Tuesday, the International Atomic Energy Agency said that its inspections had found that centrifuge equipment made indigenously in Iran — but not imported gear — showed many traces of the concentrated fuel, leading experts to doubt the Iranian explanation and suggest that Iran had enriched the uranium itself. Its purity was 36 percent U-235 — short of the 90 percent needed for most nuclear bomb designs but greater than that needed for most nuclear reactors.

On Friday, however, European diplomats said the agency's laboratory at Seibersdorf, Austria, had discovered a likely match between the atomic signatures of Russian uranium and samples agency inspectors had gathered from Iranian centrifuges.

In its sleuthing, the lab studies such things as a sample's isotopes — atoms of the same element that have different numbers of neutrons. A distinctive mix of such isotopes can amount to a fingerprint that experts check against atomic databanks.

One day Malaysia, the next Russia. I emphasized the word most above. What enrichment level is needed for the Pakistan/North Korea design? Does anyone think this trade can be contained -- or just slowed?

Putin must worry about a Chechen bomb.

Friday, February 27, 2004

How GWB boosts manufacturing and overall employment -- the ketchup maneuver

Molly Ivins, Star Telegram | 02/26/2004 | No bad idea left behind

Reagan famously reduced the federal cost of school lunches by defining ketchup as a vegetable. GWB extends the master's legacy:
My personal favorite among Bush's recent moves is the proposal in his economic report to Congress to reclassify fast-food restaurants, moving them from the service sector to 'manufacturing.' This is a concept. In case you're puzzled over why your burger-flippers should now be classified with autoworkers, it's so when the administration has to report the statistics on how many manufacturing jobs we've lost, they won't look so bad.

This administration is very clever about redefining its problems. For example, when the figures indicated that the Bushies had lopsidedly benefited huge corporations as compared to small business, they just changed the definition of 'small business' to include some of the biggest corporations in the country.

The Lion King: Being a safe and relatively benevolent carnivore

Whence the Beef? - The gruesome trip from pasture to platter (and how to ensure that it's not so bad). By Laurie Snyder

It's not that easy to be a Lion King -- ironically it's easiest for beef. Just as with any consumer good, brands matter. It's the reputation of the brand that validates the labels, not any regulatory agency. The early 21st century is an age where identity and reputation are fundamental, just as in the early 19th century, in part due to a libertarian current in our cultural evolution. For meat as with email ....
[beef]... To be certified "organic," cattle must be raised without hormones or antibiotics of any kind and must eat only pesticide-free vegetarian feed. Beef labeled "grass-fed" is the favorite of many animal rights activists. ... keep an eye out for labels that read "never confined to a feedlot." .... Two for grass-fed beef are www.meadowraisedmeats.com and www.eatwild.com.

[pork] ... As with organic beef, organic pork is vegetarian, and antibiotic- and hormone-free, but may have spent months in cramped CAFOs. Some producers also sell what they call free-range or meadow-raised pork, meaning pigs that are pastured for much of the year... But there are no restrictions on the use of these terms, so be sure to ask for the details.

[turkey - the author didn't have any alternative to suggest! Sounds like wild turkeys can't be effectively harvested. Too fast!]

[eggs - she only mentions McDonald's?] Fast-food giant McDonald's announced in 2000 that all producers who supply its eggs must give hens 72 square inches each (more than three times what they typically get), cannot use forced-molting, and should stop de-beaking chicks.

[poultry] ....According to activists, turkeys and chickens labeled "free range" didn't necessarily enjoy much more mobility than their CAFO-raised peers. In the United States, poultry can be labeled free-range as long as there's some access to the outdoors, for some of the birds in a flock. Free-range chicks are still often de-beaked, and free-range egg-laying hens still spend their days in battery cages—they just have a bit more room to move about. One term to keep an eye out for is "cage free"—fowl raised in open spaces are likely a bit better off.

Krugman on free trade

Op-Ed Columnist: The Trade Tightrope
The point is that free trade is politically viable only if it's backed by effective job creation measures and a strong domestic social safety net.

Economists argue about a lot of things, but the benefits of trade are to economics as natural selection is to biology. Krugman defends free trade as he must and should.

Economists do fight about how best to help the "losers" free trade produces. Conservatives favor tax cuts, liberals favor training and unemployment insurance. That's a legitimate fight. I favor 529 plans to cover living costs when unemployed and retraining with mandatory contributions when employed. That's a policy many Republicans would accept.

Where Republicans are vulnerable is health care and benefits. These need to be removed from employment. Krugman is starting to talk about this. It's a winner for Kerry.

Monday, February 23, 2004

Great NYT Review on Autism

Lifting the Veils of Autism, One by One by One
Very interesting. The NYT has had very good autism coverage.

Dietary supplements stop dementia in beagles? AAAS proceedings

In beagles, at least, there's evidence that diet can impact brain health ...
Economist.com | Dogs and medicine - Anti-oxidant anti-dementia therapy (for Beagles): Vitamin C, Vitamin E, alpha-lipoic acid, acetyl-l-carnitine.
... Carl Cotman and his colleagues at the University of California, Irvine, have been using beagles to investigate the effects of diet on the decline of brain function that accompanies ageing. Dogs are a useful stand-in for people in such experiments because the way memory declines in the two species seems comparable. Memory loss in dogs is accompanied by the formation of so-called amyloid plaques in the brain. Rodents, the usual stand-in mammals used in medical research, do not tend to accumulate such plaques as they age. In people, amyloid plaques are one of the symptoms of Alzheimer's disease.

... Dr Cotman wanted to know whether a diet rich in antioxidants, such as vitamins C and E, could relieve the symptoms of an ageing brain. Oxidative stress within the brain, which causes the production of molecules known as free radicals, increases with age. Free radicals can damage—and eventually kill—brain cells.

The results astonished the researchers. Not only did the antioxidant-rich diet halt age-related decline, it actually reversed it. While beagles on a normal diet continued to lose their cognitive abilities as they got older, those on the experimental diet showed improvements in learning and memory. These dogs could do much more complicated tasks, and made fewer mistakes. They could also re-learn tasks that they could do when they were younger, but had forgotten. And the diet (which, besides the vitamins, contained two food supplements called alpha-lipoic acid and acetyl-l-carnitine, that help to stop free radicals forming in the first place) also reduced the accumulation of amyloid plaques in the beagles' brains...
Ok. Why wasn't this a headliner in all the science summaries I review? There are so many implications of this research.

First, what's with dogs? I love dogs as much as the next geek, but they are starting to seem a bit odd. How much do they have in common with humans, anyway? In a previous posting I joked about dogs being a synthetic species designed to civilize pre-agricultural humanity...

Lunatic speculation aside, there are other implications here. Such as ...
  1. Would I add this to my elderly dog's dinner?
  2. Would I recommend it to everyone over 80 with memory problems?
  3. Will I (44yo) start taking it myself?
But first, the caveats (lots of them):
  1. Results like this are often misinterpreted or reversed on appeal. On the other hand, this isn't the first result of this sort, only the most dramatic.
  2. When a "natural" "supplement" alters physiology, it's a drug. These substances are being administered in doses much higher than in a human or canine diet. They're acting like medications, "natural" or not, they're drugs. Most drugs have side-effects and drug interactions, good sides and bad sides. These will be no exception.
    We don't really know what role antioxidants play in disease. In 1996 the CARET study found an increased rate of lung cancer among clinical trial smokers taking antioxidants. Since then researchers have wondered if antioxidants are a key part of the tumor surveillance system. So one big caveat is the relationship between Alzheimer's dementia and brain tumors. What if suppressing oxidative stress reduced the risk of plaque-associated dementia, but increased the risk of brain tumors? That would not be a great trade-off.
And now, the opinions:
  1. If my dog Molly, aged 14, didn't have a terminal disease, I'd add it to her diet. This is about as good evidence as we'll get for dogs.
  2. It's very tempting to consider for elderly people experiencing early Alzheimer's disease. A few tabs of ibuprofen, some antioxidants … . Dementia is a devastating disease, and many people would assume many risks to avert it. But see the caveats above. What if the therapy increased the risk of strokes, or lung cancer? What about interactions with other medications? Does one need all the supplements, or just some of them? How critical is the balance? Could an unbalanced regimen worsen the underlying process? How does this really work, anyway? Above all, how similar are beagles to people? We may not know the answer to these questions for decades.
  3. It's a huge leap from dogs to middle-aged humans. See all of the above. True, my memory isn't what I'd like -- but I'm probably at average risk for age 70-80 dementia, which implies significant impairment starting in about 10 years. Again, what if this antioxidant therapy knocked out a major component of the body's tumor suppression mechanism? OTOH, if I were at high risk for impairment within a 10 year time frame, I'd be phoning my neurologist now. Just to get them thinking.
Bottom line, very interesting. Alzheimer's is one of the major causes of dementia. Preventing Alzheimer's would, all by itself, resolve our social security and medicare crises. It would mean more people could be economically productive longer.

India and outsourcing: Friedman 1, Kristof 0

NYT Friedman: Meet the Zippies
With 54 percent of India under the age of 25 — that's 555 million people — six out of 10 Indian households have at least one zippie, Outlook says. And a growing slice of them (most Indians are still poor village-dwellers) will be able to do your white-collar job as well as you for a fraction of the pay. Indian zippies are one reason outsourcing is becoming the hot issue in this year's U.S. presidential campaign.
About two weeks ago Kristof, one of my favorite columnists, wrote a very atypically dumb column on this topic. Kristof said then that America needs to invest in more college education to meet the new age. Duh.

Friedman wins this match. Great column. Reich's recommendations are mine as well, except I think wage insurance won't fly. I do think that the 401K and its equivalents need to become life-event rather than age driven, and all benefits need to be unrelated to employment. Employment should be wages, nothing else.

Friedman/Reich point out that outsourcing is a tax deductible business expense. The tax code should NOT be facilitating outsourcing. It shouldn't obstruct it, but neither should it encourage it. That can be changed.

The world needs China and India to be wealthy. These are two sources of extraordinary power and vigor, and the US is acting as a short-circuit between them. If we capture a fraction of that current we can share in the wealth, but we can't do it with our current social support network. We need another solution.

BTW, Robert Cringely is another writer who's got it.

Good for Friedman. Even if he is a Bush apologist.

Sunday, February 22, 2004

On the brilliance of dogs

Economist.com | Dog behaviour
... Dr Hare's hypothesis is that dogs are superbly sensitive to social cues from people. That enables them to fit in with human society. On one level, this might sound common sense. But humans are such sociable animals that they frequently fail to realise just how unusual are their own skills at communicating. Dr Hare therefore decided to test his idea by comparing the abilities of dogs with those of chimpanzees, which are often regarded as second only to people in their level of innate intelligence.

His experiment was simple. He presented his animal subjects with two inverted cups. Then he hid the cups behind a screen, put a small piece of food under one of them, and took the screen away. The animal had to choose which cup to look under. If the experimenter gave no cue, both species got it right 50% of the time, as would be expected. However, if he signalled in some way which was the right cup, by pointing at it, tapping it, or even just gazing at it, a dog would choose correctly every time, while a chimpanzee would still do only slightly better than chance. Chimps simply did not get the idea of social signals of this sort, however many times the experiment was repeated.

For years dogs were the neglected research subject. Domesticated, they were not nearly as romantic a subject as wolves, eagles, whales, etc.

That's changed. Dogs are a peculiar animal. They demonstrate astonishing plasticity in morphology and, now, in cognition. They are a single species with a 300% range in aging velocity. In a fairly brief period of time, only about 15,000 years, they adapted with astonishing speed to a new ecological niche -- the human host. They wormed their way into our society, becoming the second most prolific large mammal in the history of the planet. I suspect they also changed humanity, and the balance of power within early human social networks.

Hmm. Makes one think of a great idea for a science fiction short story. A hopelessly psychotic species is civilized by introducing an adaptive parasite that alters human evolution ...

One also wonders what would become of dogs if humans were to disappear? They might continue to prove themselves quite adaptable.

Ralph Nader -- funding by Rove?

BBC NEWS | Americas | Nader announces presidential bid
Our correspondent says with so much antagonism, even among his own former supporters, Ralph Nader's first problem will be getting enough signatures even to get himself onto the ballot in many states.

The most charitable explanation is that Nader truly believes that American democracy has collapsed. There are many people worried about the health of American democracy, but maybe Nader thinks we're gone over the edge into a covert police state.

A less charitable explanation is that he's an insane megalomaniac who'll take down the world to feed his ego.

Either way, he has guaranteed funding. A tiny portion of the Rove/Bush bankroll will ensure Nader gets the 1-3% of the vote needed to tip the election to Bush. The only mystery is whether Rove need be all that covert about how he funds Nader. After all, if Ralph believes the system is hopelessly corrupt, he might as well take Rove's money.

Saturday, February 21, 2004

Neo-Feudalism: Return of the Trades

Essay: A Prettier Jobs Picture?
[The Bureau of Labor Statistics] ... is much less adept at counting employees in small businesses, simply because there are too many small enterprises to representatively sample them. The bureau's occupational survey, which might suggest which jobs are growing, doesn't count self-employed people or partners in unincorporated businesses at all. And many of today's growing industries, the ones adding jobs even amid the recession, are comprised largely of small companies and self-employed individuals. That is particularly true for aesthetic crafts, from graphic designers and cosmetic dentists to gardeners. These specialists' skills are in ever greater demand, yet they tend to work for themselves or in partnerships.

Ahh, yes. The aesthetic crafts. Minstrels and gardeners, servants and carpenters. I had quite an interesting discussion the other day with a master carpenter who makes a fine living doing cabinets ... on yachts.

No more inheritance tax. Increasing concentration of wealth by inheritance, network effects ("winner take all"), regressive taxation and tax avoidance. It all adds up to an increasingly wealthy and powerful elite and an army of gardeners, entertainers, tradesman and craftsman to serve them. Don't send your children to college, let them be minstrels.

The last time we did this there were barons and kings upon the land, and the wealthy lived in walled cities surrounded by the heaving masses ...

Tne Malaysian Connection: the diffusion of nuclear weapons (washingtonpost.com)

Insider Tells Of Nuclear Deals, Cash (washingtonpost.com)
Tahir, however, had turned his attention to Malaysia, marrying the daughter of a former Malaysian diplomat in a society wedding in 1998 and gaining permanent residency there.

He also saw business opportunities. Though he had planned in 2001 to manufacture centrifuge components in Turkey with a Turkish associate, police said, Tahir changed his mind and suggested that the parts be produced by a politically connected Malaysian company, Scomi Precision Engineering.

An astounding story is unraveling, beyond the best of Ian Fleming. A wonderful and terrible example the power of markets.

Tahir was a key player in the China-Pakistan-Libya-Malaysia-Iran (more to come) nuclear weapons trade. The Malaysia connection is highly interesting. Malaysia is a high tech manufacturing nation ruled by Mahathir (semi-retired), an autocratic tyrant with a record of successful rule and a hatred of the "West". It is a police state. Did Mahathir know that a Malaysian engineering firm was doing high tech manufacturing for Libya's bomb?

The other thread in this story is the astounding capabilities of the IAEA and Mohammed el Baradei. Maybe he could assume command of the CIA?