Thursday, July 02, 2015

Automating medical error: misadventures in medication reconciliation

I recently enjoyed a nasal surgery procedure. More on that in a later post, this one is about a medical error that followed the surgery. It’s a kind of error that fits my professional work in clinical computing (“medical informatics”).

The error, actually multiple errors, showed up in a part of my computer generated post-operative discharge summary labeled “CONTINUE taking these medications”. In the clinical computing industry this is the “medication reconciliation” or “medrec” section…

AHRQ Patient Safety Network - Medication Reconciliation

Patients often receive new medications or have changes made to their existing medications at times of transitions in care—upon hospital admission, transfer from one unit to another during hospitalization, or discharge from the hospital to home or another facility. Although most of these changes are intentional, unintended changes occur frequently for a variety of reasons. For example, hospital-based clinicians might not be able to easily access patients' complete pre-admission medication lists, or may be unaware of recent medication changes. As a result, the new medication regimen prescribed at the time of discharge may inadvertently omit needed medications, unnecessarily duplicate existing therapies, or contain incorrect dosages. These discrepancies place patients at risk for adverse drug events (ADEs), which have been shown to be one of the most common types of adverse events after hospital discharge. Medication reconciliation refers to the process of avoiding such inadvertent inconsistencies across transitions in care by reviewing the patient's complete medication regimen at the time of admission, transfer, and discharge and comparing it with the regimen being considered for the new setting of care.

Most of the electronic health record (EHR) industry more-or-less automated medrec in the 00s. Typically a physician (usually this is a physician task) reviews a list of “existing” (tricky term!) medications as well as “new” meds and, in theory, produces a reconciled list that  fits the patient’s current sate.

That’s the theory; in practice the “existing” medication list is often incorrect.  Additionally, it’s usually quite easy to, with a click or two, replicate the “existing” medication list without the tedious work of actually reviewing it.

Both errors, and more, showed up in the “continue” list I was given for:

  • Afrin 2 sprays 2 times a day
  • Flonase 50 mcg/actuation
  • fluticasone 50mcg 1 spray into each nostril daily
  • azelastine 137 mcg 2 sprays into each nostril two times a day.
Let’s count the errors:
  • None of these meds are appropriate for my post-op fully obstructed nose. The Afrin and steroid sprays are theoretically harmful, but in practice none of them would go anywhere anyway. So that’s 3-4 errors depending on how one treats Flonase/fluticasone. These is most likely either physician inattention or a process error.
  • Flonase and fluticasone are Brand and Unbranded names for the same medication. This is a software error or a data entry/design error (accepting free text meds rather than “coded" meds).
  • The Afrin dose and frequency is incorrect, it would be dangerous to use it so often. This is likely a physician error. (I actually corrected this during an office visit, but my correction was evidently ignored.)
  • The list omits QNasl. This almost certainly an error in compiling the “existing medication” list, but like all the others it shouldn’t have been on the list post-of. I’ll count this as an error anyway.
So in one medication reconciliation process we have 7 errors, 1 which is probably software (Flonase/fluticasone resolution) and 6 which are physician/process errors likely facilitated by poor software design.

In this case no harm was done. My wife and I are both physicians; we knew to ignore the errors. There might have been a small potential for harm with a non-expert patient, but in practice the nasal meds aren’t going to get far in a post-op obstructed nose. Obviously there’s potential for harm in different cases, which is why “medrec” has been a patient safety goal for the past … well … 25 years or so.

This isn’t a new problem — Emily and I both remember common medication reconciliation errors in the pen and paper era. I suspect, however, that quick-click list merges may make it faster and easier to make the same old mistakes.

It would be nice to think about what we could do differently…

Saturday, May 23, 2015

Story of our times - What happened to screen door latches?

This is the only screen door latch design sold in our local hardware stores:

 

The t-shaped metal bar in the center has two prongs that join the indoor mechanism. One first mounts the outdoor handle mechanism, then joins the bar to the indoor mechanism  and attaches it to the door. The bar slides into the outdoor mechanism collar. There’s no stop or spring in the outdoor mechanism, the bar can easily slide in and out. Only the two metal prongs at the tip hold it to the indoor mechanism.

After about 6-8 weeks of use at our home those prongs come loose, the bar slides deeper into the outdoor handle, and it is no longer possible to open the door. 

It’s a bad design. There should be a better way to attach the bar to the indoor mechanism, or there should be a spring in the outside handle.

This is different from the quality issues that afflicted toasters in 2006; the mechanisms are well made. It’s just that they’re well made to a hopelessly bad design.

I wonder if, years ago, a Chinese manufacturer incorrectly copied an older design. But why did it become universal?

I’m half-heartedly looking for a different design, but the market is probably telling us that nobody has a wooden screen door in 2015. We need to replace the door with something that will lose less heat in the winter.

Weird, and somehow characteristic of our times.

Crime and the enterprise

What do Seagrams, YouTube, Uber, Elon Musk’s PayPal, 1930’s McKesson, Jobs Rip. Mix. Burn, and Las Vegas have in common?

Many very successful enterprises have a history of unethical or criminal behavior. Sometimes there are convictions, sometimes not. The history is usually buried, sometimes it’s romanticized. Occasionally, as with Enron, the crime ends the enterprise.

I think if one wrapped the average CEO with Wonder Woman’s Lasso of Truth they’d confess to lesser versions of the kinds of sins that put Bernard Madoff in jail.

We don’t pay enough attention to this.

Fixing the iPad: Family share and iBooks

It’s a geek consensus - the iPad is on its last legs. Mostly this is because it’s nuts to have both a single-user iPhone 6 and a single-user iPad. You gotta be both top 2% for assets and have time to burn. Everyone else will do with either an iPhone 6 or 6+ (or Android equivalents).

There are obvious future fixes. One is for Apple to sell an iPhoneMini, based on tech developed for the failing aWatch [1], and a complementary iPad. That complementary iPad would work standalone, but it would also seamlessly switch between iCloud/iPhone user profiles — so a family of four iPhones might start with one iPad but move up to three (see also). [2]

There’s something else that’s gotten lost though — and I want to call this out. eBook adoption has stalled. That includes eTexbook adoption — my daughter’s school backpack is still 25 lbs. The iPad has dramatically failed to delivery on reading device expectations.

That’s big — because reading is what the iPad does best. Chromebooks have clobbered iPads in the classroom because, without the reading advantage, Chromebooks win on cost, durability, ease of management, lack of theft appeal, and suitability to traditional educational models. Video? Easier to watch up close on a lighter phablet, or rest your arms and use an AppleTV.

So it’s not enough to fix the iPad’s standalone single-user device model. Apple has to make the iPad a first class reading device. Google owns the K12 market now, but there’s still an opening in the post-secondary textbook market. More importantly, there’s the global market for books and magazines.

For that market, Apple needs to rethink its DRM approach. Sure, keep FairPlay proprietary for video — but use something else for books. Something that’s owned by an independent standards body and licenses for free along with a cross-platform authoring tool. Or, more radically, start paying authors up front for non-exclusive book distribution and then publish without DRM.

Be creative Apple. The iPad is too good an idea to die quietly.

[1] There’s an emerging consensus that aWatch 1.0 has failed. I expected it to fail in the US, but we need to see what happens in China. There’s a lot of room for improvement beyond 1.0 though: "A waterproof $150 iOS 8 Nano-clip replacement in Sept 2015 will be interesting. Splitting the cellular phone into multiple components, for which iPad and Apple Watch are interaction elements will be interesting. Standalone Apple Watch 4 running on next-generation LTE will be interesting.”

[2] Apple’s FairPlay Family Sharing, iCloud enhancements, and iOS 8 handoff do point in this direction.

Reorganizations - did Petronius Arbiter really say that in AD 27? No.

John Halamka is unhappy with the direction of federal health computing initiatives. He’s not alone, just about everyone outside of Madison Wisconsin is unhappy. My prescription would differ from John’s, and maybe I’ll write about that one day, but that’s not what this post is about.

This post is about a quote he references:

As Petronius Arbiter said in 27 A.D., we have to avoid change purely for the sake of change as this creates frustration

“We trained hard—but it seemed that every time we were beginning to form up into teams we were reorganized. I was to learn later in life that we tend to meet any new situation by reorganizing, and what a wonderful method it can be for creating the illusion of progress while actually producing confusion, inefficiency, and demoralization.”

On the one hand, this is perfect. I speak, of course, from experience. I’ve lived through reorg death spirals — when the reorg interval falls below 12 months the end is quite near.

On the other hand, it’s too perfect. It turns out we know very little about Gaius Petronius Arbiter except that he hung out with Nero. Even allowing for the slanderous and largely fictional descriptions of the Roman emperors, he was probably no pillar of virtue. This doesn’t really feel like something a Nero flunky would say.

Turns out, it’s a misattribution. The original was by Charlton Ogburn (1911–1998) in “Merrill’s Marauders: The truth about an incredible adventure” in the January 1957 issue of Harper’s Magazine …

We trained hard, but it seemed that every time we were beginning to form up into teams we would be reorganized. Presumably the plans for our employment were being changed. I was to learn later in life that, perhaps because we are so good at organizing, we tend as a nation to meet any new situation by reorganizing; and a wonderful method it can be for creating the illusion of progress while producing confusion, inefficiency and demoralization."

Ogburn’s article isn’t freely available, but you can read about Merrill’s Marauders: "a United States Army long range penetration special operations jungle warfare unit, which fought in the South-East Asian theatre of World War II, or China-Burma-India Theater (CBI). The unit became famous for its deep-penetration missions behind Japanese lines, often engaging Japanese forces superior in number.” They had a blood and brutal story. I have no idea how that connects to Ogburn’s observation on reorgs. Anyone know?

Wednesday, May 20, 2015

Medical research is hard - two NYT articles on Losartan for Marfan syndrome.

In 2013 the NYT’s Gina Kolata was optimistic about using Losartan, an angiotensin II receptor blocker (ARB), to treat Marfan’s syndrome …

… He sought a way to block the function of T.G.F.-beta and found a widely used blood pressure drug, losartan, that did just that.

In the mice, the drug prevented features of the syndrome, including ballooning of the aorta. Instead of dying of aortic aneurysms by three months of age, the mice lived a normal life span of two years…

… The Specks enrolled Daniel, and suspect he got losartan. His mother said the family saw “wonderful changes — everything started to stabilize.” Daniel’s aorta had been “growing astronomically,” she said, and that growth slowed so much that he would not qualify if he tried to enter the trial today. He also developed better muscle tone and more body fat.

When his time in the trial ended, the Specks were told Daniel could take losartan or the older drug, whichever they preferred. Ms. Speck did not want to take any chances. They chose both…

The human trial wasn’t finished at the time of publication but everyone was optimistic.

A year later Ms. Kolata wrote a followup article…

Heart Drug, Losartan, Falls Short of Promise in a Study - NYTimes.com

The idea seemed compelling: A blood pressure drug was found to block the effects of a gene mutation that causes Marfan syndrome, a condition that leads to terrible heart problems. The drug worked in mice with a gene that causes Marfan, doing just what everyone hoped it would do. A pilot study with 17 children showed the drug seemed to work in them, too, although there was no group that, for comparison, did not get the drug.

Now the more objective human evidence is in — results from a large clinical trial testing the experimental drug against the standard treatment. There was no difference in outcomes

The standard treatment is a beta blocker - atenolol. It’s thought both drugs work better than placebo, so losartan isn’t necessarily ineffective, it just doesn’t seem to work as well in humans as it does in genetically modified mice.

Medical research is hard.

PS. I found the 2013 Losartan ref in my Pinboard share stream, specifically, in an accidentally untagged portion the stream I was reviewing. Seeing it I wondered if there was a followup article….

 

Wednesday, May 13, 2015

Paul Theroux's 1976 visit to Santa Ana, El Salvador - repeat on 2015 Google Street View

Paul Theroux’s The Old Patagonian Express was published in 1979. Today it’s as much historical document as travel guide. Part of that history is experiencing the semi-conscious neocolonial attitudes of 1970s Theroux, though that’s probably his personality as much as the times.

There’s a lot he disdains, but he liked Santa Ana El Salvador. At one point he claims it wasn’t on his map; for him it was a pleasant surprise.

Today you can retrace his journey with very limited version of Google Street View. You can’t navigate in the usual Street View way, but you can visit the primary plaza and you can browse user contributed images.

I wonder how long it will be for Santa Ana to go full Street View. On the one hand it’s amazing what’s there now, but it’s noteworthy that Santa Ana is still a bit mysterious.

How to (properly) use a nasal spray

It’s spring in Minnesota, so a new allergy season. Many of us are restarting our nasal sprays - often Flonase, which just went ‘over-the-counter’. Many of us are also doing it wrong.

I know I have, and I know most physicians don’t describe proper use. Mostly because most physicians don’t know there’s a right and wrong way. I recently interrogated an allergist (they do know this stuff) and here’s what I learned:

  • Don’t snort it. Breathe normally or don’t breath.
  • Don’t jam the nozzle up the schnozzle (sorry). Just a few mm in.
  • Aim away from the septum — there’s nothing there to spray, it runs out, and it can hurt the thin mucosa there. Aim towards eye on same side of nostril.
  • If you cross-over, use right hand to spray left side and vice-versa, you get right position.
  • Don’t mix sprays or mix with nasal irrigation. Volume effect — one spray solution washes out another. Recommendation is to space 1 hour apart. (Which is a pain. I wonder how real this is, but that’s the party line.)

Now you know. Go forth and sin no more.

Monday, May 11, 2015

A data lock free local file format for a concept map or mind map application

It occurred to me, probably not for the first time, that there’s a natural local file store data lock free ‘file format’ for a concept map or mind map application.

Treat each node as a file system directory (folder) and make the node name the name of the folder. Treat hierarchical relationships between nodes as container relationships in the file system. Represent other arcs as hard links (unix) or soft links/shortcuts/alias contained with a folder. (Would be good to be able to distinguish Aliases that represent relationships between nodes from Aliases to system files that are properties of the node, such as an nvAlt/Simplenote text file.)

Treat other contents of a folder as properties of the node, such as notes (plain text, RTF, etc). 

And so on.

That’s the file “format”, the UI can be any variant of current Mindmap/concept map. User interactions turn into file system calls.

I’m sure someone has done this somewhere. Anyone know of a reference?

Sunday, May 10, 2015

Happy accident fraud - Feds move on Aetna and other health insurers with deceptive provider listings

Happy accident frauds are emergent frauds — nobody needs to plan them. Don’t put your Disability Claims office on the fifth floor of a building with a faulty elevator to defraud anyone, just do it for the cheap rent. Then save costs by replacing your customer support staff with an automated call management system.

The insurance industry is great at emergent frauds enabled by complexity and powered by perverse incentives. It’s baked into their business model; any player who doesn’t cheat will go bankrupt.

So it’s not surprising that health insurers competing in public marketplaces have produced inaccurate physician directories. It’s not limited to public ACA style coverage, we get our Minnesota health care through an employer plan, and after we chose Aetna we discovered their oral surgery listings were fictional. They seemed to have many providers available in our area, but all the ones we called said the listing was wrong.

Why pay the costs to maintain an accurate listing when an inaccurate listing gets you customers who can’t actually make claims?

The good news is that the Obama administration is now starting to address the problem. Alas, the fines are likely to be pathetically small, we’ll need class action litigation to really change things or find ways to drive the worst offenders out of business by failure of ‘network adequacy’. (emphases mine, note the related problem of prince concealment in the industry, another part of a fundamentally murky business)

White House Moves to Fix 2 Key Consumer Complaints About Health Care Law - NYTimes.com

The White House is moving to address two of the most common consumer complaints about the sale of health insurance under the Affordable Care Act: that doctor directories are inaccurate, and that patients are hit with unexpected bills for costs not covered by insurance.

Federal health officials said this week that they would require insurers to update and correct “provider directories” at least once a month, with financial penalties for insurers that failed to do so. In addition, they hope to provide an “out-of-pocket cost calculator” to estimate the total annual cost under a given health insurance plan. The calculator would take account of premiums, subsidies, co-payments, deductibles and other out-of-pocket costs, as well as a person’s age and medical needs.

Since insurers began selling coverage through public marketplaces 19 months ago, many consumers and doctors have complained that the physician directories are full of inaccuracies. “These directories are almost out of date as soon as they are printed,” said Kevin J. Counihan, the chief executive of the federal insurance marketplace.

Medicare and Medicaid officials have found similar problems in the directories of insurance companies that manage care for beneficiaries of those programs. In December, federal investigators said that more than a third of doctors listed as participating in Medicaid plans could not be found at the locations listed.

The new standards significantly strengthen an earlier rule, which required insurers to publish directories online and to make paper copies available on request. In the federal exchange, violations are subject to civil penalties of up to $100 a day [ed: 0.000001% of revenue?for each person adversely affected.

Federal officials said that inaccurate provider directories could be a sign of larger problems. If doctors listed in a directory are not available or are not taking new patients, consumers may not have access to covered services, and the insurers may not meet federal standards for “network adequacy,” the officials said. Consumers must often pay extra when they use doctors outside the network of their health plan, so an inaccurate directory could also lead to higher costs for patients.

Aetna says that data in its directory is “subject to change at any time.” UnitedHealth tells Medicare beneficiaries, “A doctor listed in the directory when you enroll in a plan may not be available when your benefits become effective.” …

See also:

Monday, May 04, 2015

Alpha (the better twitter) on app.net 1 year post-death, is like this...

Alpha (the better twitter) on app.net, 1 year post-death, is like this (xkcd: Undocumented Feature  by Randall Munroe, used with permission):



I’ve read we have 1,200 active members now.

One day I’ll write a post about life in a highly transient technology environment and what this might mean. Maybe I’ll just quote Vernor Vinge.

Thursday, April 30, 2015

The NYT web site is becoming unreadable on my iPhone

I subscribe to the NYT so I can go from a Feed rendered in Reeder 2.0 on my i6 to the articles rendered in mobile WedKit. I’ve gotten used to hitting an interstitial ad on initial page view, a quick back and forth clears that. (Don’t try to hit the close button, doesn’t work.) I’ve even gotten used to hitting the ‘continue’ button they’ve embedded to make things even more painful.

Today, however, articles are so infested with interlaced ads, and so slow to render, that I’m getting to the end of the road. I sent a message via the NYT subscriber web contact form:

It is increasingly hard to read the NYT on a mobile device. My iPhone is very slow to display pages, it may be related to changes made to embed more advertising.

The articles are also now broken up by ads and harder to read.

I'm really losing patience. The next step is to give up my subscription, maybe try The Economist instead.

Somebody there needs a slap on the head.

Saturday, April 11, 2015

Tech bubble 2015: Billion dollar acquisitions financed by the "rent" we pay MegaCorp monopolies?

Stratchery claims retail investors are shielded from latest tech bubble because MegaCorp and Finance are buyers, not retail investors.

But why are MegaCorp (0.1 trillion and up publicly traded corporations) paying billions?

Largely, I suspect, to forestall competition and enable monopoly rent earnings. Incidentally sweeping up disruptive talent [1] as well as aborting potential corporate competitors.

We usually think of this acquisition bubble as driven by “paying you to borrow” interest rates, but it’s also being funded by the monopoly rents we pay oligopolies in the new gilded age.

When does it stop?

The ultimate limit is probably the ability of consumers to pay the rent(s)…

[1] Talent doesn’t have to be put to good use, just kept out of job market until threat expires. (*cough* secular stagnation *cough*). The corporate acquisition is intentional, the talent lock is partly an “invisible hand” class “happy accident”.

Sunday, April 05, 2015

Pre-Diabetes and the Diabetes Risk Prediction Tool

Until recently the USPSTF did not recommend screening for diabetes in asymptomatic adults with BP of 135/80 or less. There’s now a draft recommendation, however, that basically recommends screening everyone over 45 plus lots of people under 45:

… 45 years or older, overweight or obesity, or a first-degree relative with diabetes. Women with a history of gestational diabetes or polycystic ovarian syndrome … African Americans, American Indians/Alaska Natives, Asian Americans, Hispanics/Latinos, and Native Hawaiians/Pacific Islanders …

In other worlds, only skinny euros under 45 avoid screening.

Which makes me feel a bit better about our typically shotgun “workplace health” program. It’s been doing my fasting glucose for about 3 years. A glucose that’s consistently about 100-103 mg/dl (jumped from 82 in 2011 to 99 15 months later, which makes me wonder about something immune beating on beta cells). [2][3]

I should be under 100, typically under 90, so that’s not a good number. It’s in the “pre-diabetes” range, and the current enthusiasm is to start treatment with meds in the hope of delaying the onset of “true” diabetes. Of course there’s also the theoretical benefit of weight loss and exercise, but few people manage that. Unfortunately we know weight loss programs rarely work, and the reports of med efficacy smell dubious to me, so it’s not entirely clear how useful the “pre-diabetes” diagnosis really is. The diagnosis, of course, is likely to raise one’s health insurance costs, though ObamaCare helps somewhat.

Since I’m already a skinny fitness nut my family doc wanted to completely ignore this, presumably on the grounds that there’s nothing useful to do about it. A wise recommendation, but I’m not built that way. 

Poking around the net I found a BMJ article on a statistical model that tries to put some personalized precision medicine context around that fasting glucose. The researchers settled on 7 factors [1] that seemed to predict 3 year conversion to diabetes (yeah, only 3 year range). So I ran the Diabetes risk prediction tool on myself. 

I got 91 points; the instrument recommends consideration of preventive steps for scores of 146 and up. Which vindicates my FP’s intuition (maybe she does the instrument in her head?).

Figuring out what 91 points means for 3 year conversion to Diabetes is a lot harder. I didn’t find anything that mapped scores onto risk quartiles! The data on 3 y progression ti diabetes per quartile was, very roughly:

  • 1st quarter: 10%
  • 2nd quartile: 20%
  • 3rd quartile: 30%
  • 4th quartile: 60%

I’m guessing my odds are probably in the 25-30% range over 3 years. So pretty high over 10 years, but the bottom line is that there’s really not enough data to justify taking an (invariably) icky medicine.

So I’ll just keep playing with my glucometer [2]…

[1] The HbA1c (glycosylated Hb) value is weird in this study. Normal HbA1c is usually given as 4.0-5.9%, but in this study anything above 4 starts to pile on bad points. This could be either a sign that there’s something funky with their model, or a sign that we should redefine the normal range for HbA1c (I’m 5.2, “normal”, but on their chart it lines up with a fasting glucose of about 105).

Lastly, the paper text says “baseline fasting glucose was by far the most important predictor” which does make me wonder if the other 6 factors mean anything.

[2] Since I’m kind of curious about what’s going on I bought a glucometer on Amazon (I paid $28 or so, it’s $11 today. They make their money on the proprietary strips.) My 1-2h post-prandial glucose is identical to my fasting glucose — 103. “Normal” is less than 140. So that’s weird. Next time i’ll redo the standard sample test — maybe the glucometer is dead. Or maybe the FBG/PPG ratio is an interesting predictor  …

[3] I do idly wonder about getting a TSH (thyroid stimulating hormone).

See also

Saturday, April 04, 2015

I want a Zenith CruisePad for my iPhone

I finally realized what I want.

I don’t want an iPad.

I don’t want an aWatch.

I want a Zenith CruisePad for my iPhone …

Rather than a free-standing slate/tablet computer, the Zenith CruisePAD was a remote terminal to one's PC. It was designed to allow the user to interact with that PC's applications from a distance over a wireless network. What made it interesting to me was that it let one do so directly on the CruisePAD's screen, using either a stylus or finger.

This was an interesting approach given when it was released. In that year, 1995, neither Wi-Fi (which came into existence in 1999 with the formation of the Wi-Fi Alliance), nor the IEEE 802.11 protocols on which it was based, were available (the original version of the IEEE 802.11 standard was not released until 1997). Hence, it relied upon a proprietary 2.4 Ghz spread-spectrum radio protocol which they called CruiseLAN…

We played with tech like this at a 1990s Electronic Health Record/transaction processing startup called Abaton.com (no trace of it on the web btw, domain taken long ago). Ultimately impractical, but very cool. This was the era of the PalmPilot device, and we (ok, I) imagined walking up to a wall display and automatically switching from the itty-bitty Palm display to something real big.

That’s what I want for my iPhone. I don’t want the cost and hassle of another OS with all of the overhead of apps and licensing and bugs and DRM restrictions and updates and hacks. I just want a frigging wireless dumb display that can be shared between multiple devices. It would be nice to play video on it, but really I want to read. I’d be delighted if it used Digital Ink and cost $100 with a 1 week battery life.

That’s what I want. Google is much more likely to do this on Android than Apple on iOS; it’s the one thing that might tempt me to the Dark Side.

I wonder if Apple’s App Store rules prevent a 3rd party (Amazon?) from producing a reading app that would communicate with a Digital Ink display via Bluetooth….