So my eyes bugged out when the first hit I got was on Wikipedia, and it was an excellent description, probably written by a bored dermatologist (though I must admit that dermatology is more lively than industrial ontology):
Howel-Evans syndrome - Wikipedia, the free encyclopediaWikipedia is an honest-to-goodness 21st century wonder.
Howel-Evans syndrome is an extremely rare condition in which the skin of the palms of the hands, and soles of the feet, are affected (hyperkeratosis). The effects on the palms and soles is called tylosis, and in Howel-Evans syndrome, there is a predisposition to oesophageal cancer, particularly squamous cell carcinoma.
Howel-Evans syndrome was described in 1996 as being identical with palmoplantar ectodermal dysplasia type III...