Stress, disease and early aging

The NYT Magazine has a long article on disease and aging though I think the lead family photo is a big misleading (look yourself and contemplate). It doesn't have many surprises in it. It's one of a series of discoveries and reviews that show we age more slowly than we once did, largely because we're sick less often.

The main environmental influences are probably prenatal and certainly before age two (mothers should never smoke), but, there are later effects too. At least for the moment, we are spared much of the disease, parasites, and malnutrition that afflicted our ancestors. As a consequence, we age more slowly.

This is not a surprise to anyone who's studied old family photos. Our ancesters were old at 40 -- rather than 50-55.

FuturePundit, which pointed me to the NYT article, also features a related post about a gene that can be used to tell a person's biological age rather than their chronologic age.

I'm still waiting for the article that shows that aging is non-linear, and that we experience 'bursts' of aging after certain environmental triggers. The old folk tale about 'aging a year in a night' will be shown to be correct.

Geeks don't use Travelers Insurance

JOS calls out a comically stupid and offensive ad campain by Travelers Insurance. I wonder how much business they once had in Silicon Valley.

I assume that each year ad execs gather to nominate the absolutely worst ad effort of the year. This one is reaching for the decade award.

Dyer has about 10 new articles online

The journalist, military historian, arabist and eccentric web author has about 10 new June/July articles. This journlist doesn't do he said/she said articles -- and his record is good. Dig in.

The Ultra Portable Mobile Computer is doomed

The UPMC is crushed by a 10 year old Apple Newton in a head-to-head struggle. That's pathetic. The UPMC is dead. Move along folks ...

Black skin, SPF, and when a feature becomes a bug

[Update 7/31: read the comments. The BBC article really mangled the study, and my imagination was overly active. As our commentator notes, these melanomas aren't even clearly sun related. Detection was also not a problem, the involved skin is pale. I really don't know what to make of any of this, but you probably shouldn't waste your time on this post!]

Very black skin has SPF 13; I assume that very pale skin has SPF 1-2 (the BBC article didn't say) ...

BBC NEWS | Health | Dark skin 'does not block cancer'

...people with dark skin are more likely to die from skin cancer than those with fairer skin...

Dark skin has increased epidermal melanin which provides a natural skin protection factor (SPF) - a measure of how long skin covered with sunscreen takes to burn compared with uncovered skin.

Very dark, black skin has a natural SPF of about 13 and filters twice as much UV radiation as white skin, for example.

The BBC article is pretty weak. We're talking about melanoma. Very black skin is protective against melanoma, but it also makes it harder to spot early melanoma. The detection impact is only relevant when melanoma can be treated -- a modern phenomena.

In low tech societies black skin protects against death by melanoma, in high tech societies we can cure early melanoma. So the detection problmes mean that black skin has gone from being a 'feature' to a 'bug' -- at least in terms of melanoma protection. It's still a feature in terms of protection against sunburn, even the best sunscreens require frequent reapplication.

This is analogous to climate change and fur color. White fur is protective when there's snow, a problem when the snow melts. The difference is that our environment is technological.

Asians and other brown skinned persons may have the best compromise here. A reasonable SPF protection (maybe 8?) with reasonably easy detection as well. Sunscreen there just improves the odds. Good news for my younger kids. Getting black kids and adults to wear sunscreen will be damn hard. An effective SPF 13 sunscreen that doesn't wash is good enough to avoid a lot of sunburn, and without the scourge of sunburn kids and adults aren't going to put sunscreen on...

Hezbollah, collective punishment, and the falling cost of havoc

In the winter of 2001 I thought a lot about the falling cost of havoc. Technology changes the course and nature of conflict, and the relation between states and entities.

The theme returns:

Israel Finding a Difficult Foe in Hezbollah - New York Times

.... Never before in history has a terrorist organization had such state-of-the-art military equipment,” from medium-range rockets and laser-guided antitank missiles to well-designed explosive mines that can cripple an advanced tank, General Amidror said.

The cost of advanced weaponry is falling relative to income. Offense is cheaper than defense. The "IED" (improvised explosive device) is not really improvised, and it has changed the balance of power in Iraq.

In time missiles that travel hundreds of miles, with a great deal of "intelligence" and optional remote guidance, will become commonplace.

We still haven't thought enough about how technology is changing the nature of conflict. I fear collective punishment and police states will become the rule. I wish we thought about this more.

Landis: the odd thing about the test results

On NPR a specialist in doping described Landis results differently from the news stories. This is typical of what we're reading:

KRT Wire | 07/27/2006 | Landis denies cheating, admits Tour win will be questioned

...The test conducted at France's anti-doping laboratory in Chatenay-Malabry turned up high levels of testosterone, which medical experts say can increase stamina in the short run.

According to a statement posted on the Web site of Phonak, a cycling union official informed Landis' team that the rider's sample revealed 'an unusual level of testosterone/epitestosterone' when he was tested July 20.

The story on NPR was that his free testosterone was not in fact elevated. The epitestosterone was very low, so the ratio was elevated to about 11. Anything above 6 is out of the accepted range, so a value of 11 is extreme.

I was hoping someone on medlogs would do a more clinical analysis, but so far the press reports are just repeating the elevated testosterone line. I admit I'm harboring the faint hope it's something innocent, but I'm also curious about what would mess up the ratio. An effect of another banned substance? It's been too long since I knew my endocrinology ...

Shrillblog: The History of the Shrill

DeLong writes The History of the Shrill. Made me look back to the first post. I think I joined on the 2nd post. Been reading every since.

Damn, I'm going to have to pay the NYT so I can read Krugman again ...

The most important MS Office preferences

SIVACRACY.NET: MS Office Upgrade, With Important New Features. I loved the one about "same ... default attributes". There are so many I could add that are MS Word specific. Maybe 'Destroy document after every third style applied ...'.

DeLong's top 20

DeLong lists the twenty blogs he reads most frequently. I'll check out the few I don't know.

Hijacked by the right, a scientist disembarks

A few years back a real scientist published a well respected paper noting some cooling trends in parts of Antarctica. The author became an unwitting recruit of the arational right - including performance artists like Crichton and Coulter. He chose the New York Times as his exit from the madness. My favorite line is emphasized ...

Cold, Hard Facts - New York Times

... Our results have been misused as “evidence” against global warming by Michael Crichton in his novel “State of Fear” and by Ann Coulter in her latest book, “Godless: The Church of Liberalism.” Search my name on the Web, and you will find pages of links to everything from climate discussion groups to Senate policy committee documents — all citing my 2002 study as reason to doubt that the earth is warming. One recent Web column even put words in my mouth. I have never said that “the unexpected colder climate in Antarctica may possibly be signaling a lessening of the current global warming cycle.” I have never thought such a thing either.

Our study did find that 58 percent of Antarctica cooled from 1966 to 2000. But during that period, the rest of the continent was warming. And climate models created since our paper was published have suggested a link between the lack of significant warming in Antarctica and the ozone hole over that continent. These models, conspicuously missing from the warming-skeptic literature, suggest that as the ozone hole heals — thanks to worldwide bans on ozone-destroying chemicals — all of Antarctica is likely to warm with the rest of the planet. An inconvenient truth?

Also missing from the skeptics’ arguments is the debate over our conclusions. Another group of researchers who took a different approach found no clear cooling trend in Antarctica. We still stand by our results for the period we analyzed, but unbiased reporting would acknowledge differences of scientific opinion.

The disappointing thing is that we are even debating the direction of climate change on this globally important continent. And it may not end until we have more weather stations on Antarctica and longer-term data that demonstrate a clear trend.

In the meantime, I would like to remove my name from the list of scientists who dispute global warming. I know my coauthors would as well.

Never even thought. That is pretty definite.

There's still important science to be done about what's happening over antarctica, and there's work to be done to improve climate models and better characterize all the contributors to global warming and climate change.

There's also important social science research to be done on the nature of irrationality in the American right ....

I didn't miss his slightly strained pitch for more monitoring stations in Antarctica. I'm sure that's a good thing on the merits, but it also reflects a scientist's love for his domain of study ...

Partitioning Iraq: 2003, 2006 and Leo Strauss

Sometime between 2002 and 2003, I noted two things:

• Rumsfeld is probably not a blithering idiot
• His methods in Iraq were manifestly not consistent with his stated aims

Therefore his stated aims were not his true aims. So what where (are?) his true aims?

In August of 2003 I wrote (emphasis is new below, I corrected some spelling errors too):

Bush's mishandling of the UN and Turkey, and the failure of the neoCons to listen to listen rationally to the CIA and the State Department, has really put the US behind the 8 ball. On the other hand, I don't think things are hopeless, and I'm pretty sure the UN alone won't be able to patch things up; if the US/UK leave Iraq the country will be partitioned. (I suspect Rumsfeld's strategy was always to partition Iraq between the Turks/Kurds/Iran and Kuwait, leaving a central Sunni portion without oil revenue.)

Partitioning Iraq, and surrendering the southern portion (less the oil?) to Iran now is now a commonly proposed desperate solution. No surprises there, except I thought this would come up more last year.

Why did Rumsfeld decide to partition Iraq? That’s very speculative, even by my standards. It probably has something to with Turkey — everything does in the middle east.

It may also be that this was his second choice. Perhaps given sufficient troops, allies and resources he would have aligned his methods with his stated aims. He knew from the moment Turkey dropped out, however, that the resources weren’t there. Instead he aligned his true aims with his resources but fed the original aims to the masses. A Straussian solution.

Why all the Flash based documentation? It's about languages ...

I’ve been a bit annoyed by all the Flash based software documentation I come across. I like the speed, convenience and portability of reading. I couldn’t figure out why these small demos were taking over the world…

Until I visited the BlogJet site (my Windows blogging client, alas, there’s nothing this good on the OS X side) and noticed the developers were Russian. Then I tried the Flash demo and learned something important quickly.

A lot of my favourite applications are developed by small companies with few or no employees who can write good English language documentation. It’s far cheaper and easier for these companies to illustrate key issues using a compact and fast Flash demo.

Reading and typing were very important when I was growing up. They’ll probably still be important 10 years from now … On the other hand —– 40 years from now? Who can say. Besides, not everyone thinks in words…

 

The real estate bust and the effect of mortgage statements on consumer spending

I think I can confirm this NYT impression for the Twin Cities metro area, and also suggest a reason why it may have a quicker than expected impact on consumer spending ...

Sales Slow for Homes New and Old - New York Times

Adding it all together, a variety of experts now say, the housing industry appears to be moving from a boom to something that is starting to look a lot like a bust.

We bought and sold at the height of the boom. We couldn't wait any longer. Since we traded up I expected we'd end up with a short to longer term 5-7% loss (meaning I thought we overpaid by 10% but about half that was covered by our prior home sale). Our tough.

What I didn't expect was to have this explicitly stated in our mortgage statement.

Background first. Back when home prices were climbing, our bank began putting a number on the monthly mortgage statement reflecting the increase in equity. It was a very deliberate, and somewhat evil, move to make people feel wealthier. More wealth, more borrowing, more bank revenues. Except it also means more risk, since the rising numbers were illusory.

Economists have talked about this risky 'wealth effect' of the housing bubble, but they don't often talk about how that 'wealth effect' is mediated. In our case the bank was very explicitly communicating the 'wealth effect'.

That worked well for lenders when housing prices were going up, but for some odd reason our bank didn't turn off this number when prices started falling. So we now see a negative number -- roughly in line with my expectations.

So our bank is now explicitly communicating the opposite of the wealth effect --the poverty effect. Anyone who looks at their mortgage statement, especially those who enjoyed seeing the older rising numbers, are now seeing the falling numbers.

This direct and explicit communication may accelerate the consumer response to falling housing prices. The old delays will likely compress, resulting in a faster contraction. I wonder if the Fed is expecting this ...

Interoperability, standards, and the evolution of the codon

Standards are a big deal in healthcare IT (my industry). Standards for the building blocks of knowledge, standards for the way knowledge is assembled, standards so that software can act on knowledge and exchange knowledge between systems.

It is surprisingly hard to make the case for these standards. They have an up front cost, particularly early on. If you've got something that works, why change? The strongest argument is from economics -- even if it's tough to adopt a standard, eventually network effects will mandate its use and time will address the defects. (The hard part, of course, is knowing what the real standard will be ...) The future cost may be much higher than near term adaptation ...

Now we have a possible supporting argument from the history of life on earth. Standards adoption by proto-life was important to intra-organismal interoperability ...

The Loom : In the Beginning Was Linux?:

... Scientists have long debated how the same genetic code wound up in all living things. Why twenty amino acids? Why three nucleotides? One possibility was that it was just a "frozen accident." Another has been that it evolved in an ancient lineage and provided an evolutionary edge against others with different codes. ...

...Evolution gradually produced more precise genetic codes, Woese and his colleagues argue, but different communities of microbes evolved different codes. In each community, a shared code made it easier for microbes to share genes. If you plug a gene into an organism with a radically different code, it will produce a radically different protein--mostly likely one that is useless as well. It's like grabbing a piece of software and trying to run it on the wrong operating system.

The more microbes used the same genetic code, the bigger the pool of genes they could all take advantage of. Those shared innovations benefited the entire community as it competed with communities with other genetic codes. Imagine microbes colonizing some bizarre new ecological niche--a seep of petroleum, for example, or undersea volcanic chambers. The microbes that can take advantage of more innovations will outcompete the ones that belong to the smaller community. This advantage would also drive the evolution of different genetic codes to be more like one another, because communities of microbes would get access to even more innovations.

Over time, the benefits of a big innovation pool wiped out the original diversity of rare codes, replacing it with one universal language. Only later did life begin to lose its communal nature and begin to evolve into separate lineages that we see now as the tree of life. While those lineages produced things as different as humans and bacteria, they all share the same genetic code that evolved during that communal age.

Great analysis, but a better analogy would have been file formats and software, not operating systems and software (ok, so the distinction is blurry). Government lawyers made the same mistake in the Microsoft monopoly trial and the judge made the same mistake during the penalty phase. Data formats are far more important than software. Our software/os/interpreters are quite different from those of viruses and bacteria, but the data formats persist. Microsoft should have been forced to surrender control over their data formats -- and forget about their software.

In that regard evolution has something to teach open source movements, which historically have paid far too much attention to software and not enough attention to data. Health informatics understood this twenty years ago, and now fights over file formats with state governments indicates others are catching on ...