Dementia: is it really a disease?

So is Alzheimer's-type dementia really a disease?

Prevalence of Alzheimer’s Rises 10% in 5 Years - New York Times:

... The updated estimates, based on the rising occurrences of the disease with age, not new disease research, were released yesterday by the Alzheimer’s Association, along with a compilation of other information about a progressive brain disease that afflicts 13 percent, or one in eight people 65 and over, and 42 percent of those past 85...

...Mary Mittelman, an Alzheimer’s researcher at New York University, had mixed feelings about disproportionate attention to early onset Alzheimer’s disease. On the one hand, Dr. Mittelman said, these cases are such a small minority that she fears will take focus and resources “from the majority who are much older.” On the other, she said, 'because of the ageism of this society” far too many people still believe dementia to be part of normal aging and attention to this younger group will clarify that it is a 'real disease'.”

When 42% of people over 85 have advanced features of a prolonged process, is this a "real disease" or an aging process? The boundary here is pretty fuzzy. Nobody has the brain or body at 85 that they had at 45, much less 25.

My personal bias is that the "Alzheimer's process" is a "normal" part of aging, right up there with getting weak, flabby, and shorter. What varies, of course, is how fast it progresses, and whether one dies before or after the process becomes disabling (disability also being a fuzzy term -- many persons who we consider "able" at 85 are unable to do the work they did at 45).

The distinction between an aging process and a disease has a practical implication. In general, diseases are treatable, but aging is much harder to stop. If we accpet the model of an Alzheimer's "Process" rather than Alzheimer's Disease, then we can better judge how great our challenge is. We need to do more than arrest a disease, we need to slow the aging process of the human brain. The bright side is that there's been a lot of research lately that suggests that might be possible.

Pet poisoning: 1/6 die in testing?!

Whatever the Menu Foods contaminant is, it is so lethal that it killed 7/45 animals in testing:

San Jose Mercury News - Pet food recall has owners searching for answers

... Menu Foods told the Food and Drug Administration it received the first complaints of kidney failure and deaths from pet owners Feb. 20. It began new tests Feb. 27 in which 40 to 50 dogs and cats were fed its product. During those tests seven animals died, according to the FDA's top veterinarian, Stephen F. Sundlof. The contamination appeared more deadly to cats than to dogs, he said, although the mix of species tests was not immediately known....

Other articles have added a bit more detail. The animals became ill about 5-6 days post-exposure and the chief suspect is contamination of a gluten based thickening agent at a Kansas plan..

FDA has sent inspectors to company plants in New Jersey and Kansas. Most complaints stem from products made at the latter factory, though both received shipments of wheat gluten, identified as a likely source of contamination, from the same supplier, said Stephen F. Sundlof, the FDA's chief veterinarian. The ingredient is a protein source used to thicken the pet food gravy. The FDA is screening pet food samples for substances known to be toxic to the kidneys, like toxins produced by molds.

It's impressive how little we are hearing about the testing. We're going to beef and rice at our house until we know more -- and our dog is on a dry fish based Gluten free diet (yeah, she has canine sprue - happily gluten free diets are easy for dogs). In theory we should be pretty safe, but to put it mildly we have zero trust at the moment.

Update: A Kansas source has more information. If the source is the Kansas plant, the Kansas City Star may be the best information source. This article says the contamination was detected incidentally in taste tests of an experimental product, the company wasn't looking for problems ...

... Menu Foods, according to one veterinary toxicologist, was working on some experimental products when it did some testing, and found that the food sickened or killed some animals. The company reportedly traced the problem back several weeks to when they started using a new wheat component in their foods. The company immediately stopped using that new wheat source, which it used in high concentration in the experimental food. To be safe they recalled every other brand that might contain the new wheat, even in tiny quantities.

I wonder if it will be aflatoxin again ...

The surgeon gene

FuturePundit: Sleep Gene Determines Performance Of Sleep Deprived. I bet most surgeons have the short version of the gene.

Flatland and the 248 dimensions of time

In the 19th century two dimensional world of Flatland the hero infers the existence of dimensions beyond those of his god-like 3 dimensional correspondent. He would be willing to image a 248 dimensional creature:

Is this the fabric of the universe? | Science News | Connected | Telegraph

Mathematicians have successfully scaled their equivalent of Mount Everest. Today they unveil the answer to a problem that, if written out in tiny print, would cover an area the size of Manhattan.

At the most basic level, the calculation is an arcane investigation of symmetry – in this case of an object that is 57 dimensional...

... What makes this group of symmetries so exciting is that Nature also seems to have embedded it at the heart of many bits of physics. One interpretation of why we have such a quirky list of fundamental particles is because they all result from different facets of the strange symmetries of E8. I find it rather extraordinary that of all the symmetries that mathematician’s have discovered, it is this exotic exceptional object that Nature has used to build the fabric of the universe...

... Today’s feat rests on the drive by mathematicians to study symmetries in higher dimensions. E8 is the symmetries of a geometric object that is 57-dimensional. E8 itself is 248-dimensional...

....The ways that E8 manifests itself as a symmetry group are called representations. The goal is to describe all the possible representations of E8. These representations are extremely complicated, but mathematicians describe them in terms of basic building blocks. The new result is a complete list of these building blocks for the representations of E8, and a precise description of the relations between them, all encoded in a matrix, or grid, with 453,060 rows and columns. There are 205,263,363,600 entries in all, each a mathematical expression called a polynomial.

..."This is an impressive achievement," said Hermann Nicolai, Director of the Albert Einstein Institute in Potsdam, Germany. "While mathematicians have known for a long time about the beauty and the uniqueness of E8, we physicists have come to appreciate its exceptional role only more recently - yet, in our attempts to unify gravity with the other fundamental forces into a consistent theory of quantum gravity, we now encounter it at almost every corner...

I'd love to hear an explanation of how E8 might relate to non-local action and the seemingly bizarre nature of time. Are meaning-free instantaneous communications between entangled photons instances of higher dimensional structures protruding into 4 space? Is there really only one dimension of time, or is it simply that meaning can't exist in the others?

Oh, and did those last two sentences of mine make any sense at all?

It's a thin line between being an amateur commentator on math and physics and being a complete loon! :-)

Update: Another article explained that E8 has merely 57 dimensions, but 248 symmetric rotations. Whatever that means. Mathematics left the scope of mere mortals well over a hundred years ago, it's not surprising that non-specialists should struggle with this announcement.

Industrial food and pet poisoning - lessons?

A year ago it was aflatoxin contamination killing dogs (Diamond pet food is still in business btw, the web site proclaims their lack of connection to this episode). Now it's some poison still to be named...

Pet Food Is Recalled After Link to Animal Deaths - New York Times

More than 60 million cans and pouches of dog and cat food sold under dozens of brand names were recalled on Saturday after being linked to the deaths of 10 animals.

The food was manufactured by Menu Foods, of Streetsville, Ontario, which makes wet food sold as store brands for companies like Wal-Mart, Kroger and Safeway.

The company also makes food on behalf of many brand-name pet food makers. Menu Foods said it had recalled some food made for the Iams unit of Procter & Gamble. Two other pet food companies — Nestlé Purina PetCare and Hills Pet Nutrition, the unit of Colgate-Palmolive that makes the Science Diet brand — recalled some of their products that were made by Menu Foods.

Menu Foods is recalling only certain gravy-style pet food in cans and pouches it made from Dec. 3 to March 6.

The company said in a statement that tests of its food had “failed to identify any issues with the products in question.” But it did associate the timing of the reported deaths with its use of a new supplier for wheat gluten, a source of protein. Sarah Tuite, a spokeswoman for Menu Foods, declined to name the supplier.

The reported deaths of cats and dogs have been from kidney disease, Ms. Tuite said. Symptoms vary but can include lethargy, jaundice and vomiting, she said...

The recall list on their web site is very long (there's another list for cats):

1. Americas Choice, Preferred Pets
2. Authority
3. Award
4. Best Choice
5. Big Bet
6. Big Red
7. Bloom
8. Wegmans Bruiser
9. Cadillac
10. Companion
11. Demoulas Market Basket
12. Eukanuba (ouch, that hit us)
13. Food Lion
14. Giant Companion
15. Great Choice
16. Hannaford
17. Hill Country Fare
18. Hy-Vee
19. Iams
20. Laura Lynn
21. Loving Meals
22. Meijers Main Choice
23. Mighty Dog Pouch
24. Mixables
25. Nutriplan
26. Nutro Max
27. Nutro Natural Choice
28. Nutro Ultra
29. Nutro
30. Ol'Roy Canada
31. Ol'Roy US
32. Paws
33. Pet Essentials
34. Pet Pride - Good n Meaty
35. Presidents Choice
36. Price Chopper
37. Priority Canada
38. Priority US
39. Publix
40. Roche Brothers
41. Save-A-Lot
42. Schnucks
43. Shep Dog
44. Springsfield Prize
45. Sprout
46. Stater Brothers
47. Weis Total Pet
48. Western Family US
49. White Rose
50. Winn Dixie
51. Your Pet

The pet care world is fundamentally Libertarian. So is there a lesson here about the limits of Libertarianism? Or is there a lesson about the risks of industrial food? It seems one plant fed a large portion of North American dogs and cats, so a major problem there will have a huge impact.

These episodes have further lowered my opinions of both Libertarian marketplaces and industrial food. Our family may need to look at the ridiculously expensive "organic" pet food market.

Vanguard has the security question sickness - big time

Vanguard has taken the "security question" sickness to a new level of absurdity.

If you log into Vanguard from an "unfamiliar computer" (meaning you clear your cookie cache) you have to answer a security question. This means I really have to enter critical information that "only I know".

Except these security questions are the same everywhere. If any site I answer them at is hacked, the hackers know my security question answer everywhere where they can establish my identity.

Since these questions are treated as though they were "secret", the fact that they cannot be "secret" means that they reduce rather than enhance security.

I'm tempted (only slightly) to post the answers to my "secure questions" on my public web site. I could file it under "identity theft made easy" and include my SSN, my birth date, and my favorite passwords ...

I bet Vanguard paid quite a bit for this "feature", probably from a big name consulting firm. Only smart people could possibly be so stupid.

Life in Web 2.0: just don't ask for reliability

I'd imagined that the most reliable service in the Web 2.0 world would be Google. This morning I tried to do some work with Google's industrial application deployment and domain registration service, mediated by their premier eCommerce solution (Google Checkout).

Of course, this is what I got:

Google Apps - Server error
Help | Sign out
Server error
We are unable to process your request at this time, please try again later.

Much has been made of the millennial generation's lack of concern about privacy. I think another remarkable generational difference is an expectation of unreliability, and a probabilistic strategy for managing unreliable systems.

Geezers like me, who remember when most performance was highly predictable, have more trouble with things that don't work -- especially when we're short of time.

Update: Later the process goes one step further along ...

Oops! An error occurred while processing your request.

TimesSelect: Free for a .edu address

Arrgghh. I just paid about $50 for TimeSelect:

TimesSelect University E-mail Verification

...We are pleased to offer a complimentary subscription to TimesSelect. You must be a student or faculty member with a valid college or university e-mail address to be eligible for this offer. You no longer need an access code to activate your TimesSelect University Subscription.

To start the process, please provide your school e-mail address below. If it is accepted, you will receive an e-mail from NYTimes.com with a link to continue your sign up process...

How will they distinguish academics from those with alumni accounts? I qualify as faculty, so now I'm just grumpy. I wonder if the NYT prorates upon cancelation?

Foreign Policy: latest addition to my blogroll

FP Passport is the blog of Foreign Policy, a political science journal. It's excellent. I've added it to my blogroll. (I'm still using Bloglines, but if they keep updating feeds unpredictably I'll try Google Reader.)

The Measure of Things

A colleague forwarded me one of those "interesting emails" which always seem suspicious. This anonymous message was interesting, though mysterious. It consisted of a series of images beginning with the solar system and ending with the star Antares. Once I cracked the mysterious file format. I started looking around to see if I could validate the content.

My search took me to a 2006 web page, but a very interesting faculty page (worth a visit) was probably the origin for the last 3 images (they appear relatively "home grown"). I suspect the email is based on the faculty page. A reference there pointed a physics simulation site as the original source for the first 3 images. I've attached all the images below, you can click on them to see larger images.

First, some order of magnitudes examples to warm up with:

Planck Length: 10**-35 m
String Length: 10**-35m (I thought this would be a bit bigger than the Planck length actually)
Neutrino: 10**-24m (Much smaller than a quark!)
Electron and Quarks: ? (10**-15 to 10**-18 to 0 -- the concept of "diameter" may not apply)
Proton: 10**-15 m
Hydrogen Atom: 10**-10 m
Water molecule: 10**-9m
Bacteria: 10**-7 m
Red cell: 10**-6 m
White cell: 10**-5 m
Limit of human vision: 10**-4m
Human: 1 meter
Moon and Mercury: 10**6 m
Earth: 10**7 m
Sun: 10**9 m
Arcturus: 10**10 m
Betelgeuse: 10**11 m (varies)
Antares: 10**12 m
Solar system: 10**13 m
1 Light Year: 10**16 m
Milky way Galaxy: 10**21 m
Quasar: 10**26 m (distance at time light was first emitted from furthest detectable quasar)
Visible Universe: 10**26 m
Universe/Multiverse: Unknown. Around 2007 some said 10**27, but more recent speculations are vastly larger (or infinite).

The span from the Planck Length (smallest possible distance) to the Visible Universe is a factor of 10 **61. On a log scale the mid-point is somewhere around the limit of human vision. In other words, there are as many 'scales of 10' between the smallest thing you can see and the smallest thing that can exist as there are between that wee thing and the universe. As Feynman said, there's a lot of room at the bottom.

So if we treat Earth as the measure of all things, let's take a look at some of the stellar objects in the mid-range. First, though, we'll take a look at the 'string' to 'hand' scale from (Seed magazine 2007)




Earth, Venus, Mars, Mercury and the Moon
Earth is only a bit larger than Venus, but Mars is a relative pipsqueak. It's roughly correct to say that Earth is to Mars as Mars is to the utterly barren Moon.


Jupiter, Saturn, Uranus Neptune and the rocky runts of the system.


The Sun and its leftovers


Sun, Sirius, Pollux and Arcturus
Arcturus is about 25 solar diameters across.


Arcturus, Rigel, Aldebaran, Betelgeuse, Antares
Ten Antares, laid side by side, would span our solar system. An individual human is to Antares as Antares is to our galaxy.


Update 2/4/11: The universe is much bigger than when I wrote this.

Update 5/3/12: Now what we used to call the Universe is merely the Visible Universe, which is some infinitesimal fraction of the multiverse. This Scale of the Universe app (Flash, damnit) is fun to play with. There's a lot of nothing between neutrino's and the quantum foam. I had made some egregious arithmetic errors in my original post and I just corrected them.

The mystery of the apple keyboard

I took the kids to the Apple Store tonight, and did some email on a beautiful 30" display attached to a very powerful desktop machine -- and a completely miserable keyboard.

Why are Apple's desktop keyboards so lousy? Their laptop keyboards are reasonable, it's only the desktop kbs that combine great looks with miserable performance.

Oh, yes, I know, keyboards are personal and Apple's kb gets four stars on Amazon. Bah. Show me just one geek who likes that kb (excepting Andrew)!

If Apple were to combine the cosmetics of their cheapo kb with the functionality of $9 PC kb, they'd dramatically increase the sales of their desktop machines. Trust me on this. I'm sure large numbers of XP users walk into an Apple store, type, and figure everything about Apple must be as bad as the keyboard.

Maybe it's all a plot to sell more laptops ...

Another longtime reader abandons the Economist: Crooked Timer

I abandoned The Economist last year because it seemed to been infected by the WSJ Editorial Page brainworm. It wasn't completely demented, but it was getting there. So this CT post caught my attention. I'd love to know what Fallows thinks of today's Economist. He was writing during their glory years! (Emphases mine)

Crooked Timber: Cringe and whinge

I came across James Fallows’ 1991 piece on The Economist (to which my subscription has just lapsed), The Economics of the Colonial Cringe, and thought it pretty interesting. On the one hand, this seems a little dated:

In functional terms, The Economist is more like the Wall Street Journal than like any other American publication. In each there’s a kind of war going on between the news articles and the editorial pages. The news articles are not overly biased and try to convey the complex reality of, well, the news. Meanwhile, the editorials and “leaders” push a consistent line, often at odds with the facts reported on the news pages of the same issue.

If there’s any marked difference these days between the line touted in the editorial pages line and the perspective of the news articles, I can’t detect it. The WSJ seems to still have a firewall between the two (although in fairness its editorial pages are also far loopier than those of the Economist)...

I agree. The WSJ editorial pages read like meth fueled ravings of brains debauched by mad cow disease, but their news pages are excellent. The Economist editorial pages are only moderately prion infested, but the disease has spread throughout the "newspaper" (their term).

Senator Tim Johnson is recovering

Tim Johnson's survival following a December stroke (SAH) gave the Democrats the senate. Talking Points directs us to some encouraging photos from his website.

Senator Johnson's survival and recovery must bring immense joy to his loved ones, but it has also brought immense relief to America and most of the globe. Rarely has mere survival, much less recovery, been so important to the world.

Karl Rove and the one party state

Is Karl Rove the greatest threat to American democracy since the civil war?

All roads lead to Rove | Salon.com

...Two academics, Donald C. Shields of the University of Missouri and John F. Cragan of Illinois State University, studied the pattern of U.S. attorneys' prosecutions under the Bush administration. Their conclusions in their study, "The Political Profiling of Elected Democratic Officials," are that "across the nation from 2001 through 2006 the Bush Justice Department investigated Democratic office holders and candidates at a rate more than four times greater (nearly 80 percent to 18 percent) than they investigated Republican office holders and seekers." They also report, "Data indicate that the offices of the U.S. Attorneys across the nation investigate seven times as many Democratic officials as they investigate Republican officials, a number that exceeds even the racial profiling of African Americans in traffic stops." Thus what the 85 U.S. attorneys who were not dismissed are doing is starkly detailed.

If the Democrats hadn't won the midterm elections last year there is no reason to believe that the plan to use the U.S. attorneys for political prosecutions -- as they have been used systematically under Bush -- wouldn't have gone forward completely unimpeded. Without the new Congress issuing subpoenas, there would be no exposure, no hearings, no press conferences -- no questions at all.

The replacement of the eight fired U.S. attorneys through a loophole in the Patriot Act that enables the administration to evade consultation with and confirmation by Congress is a convenient element in the well-laid scheme. But it was not ad hoc, erratic or aberrant. Rather, it was the logical outcome of a long effort to distort the constitutional framework for partisan consolidation of power into a de facto one-party state.

If his plan had succeeded, we'd have taken another large step towards a one party state, a state in which the GOP would transform the law into a means of suppressing dissent.

Rove. Cheney. Bush. There is nothing so dangerous as the righteous.

Friedman and the summer of war

Excerpted from a longer post, I particularly appreciated the zing on Friedman and the "summer of war" metaphor:

Egregious Moderation: Andrew Northrup on the Journamalism of Tom Friedman

... Of course, this is the same Tom Friedman who was telling us at the time that we needed to invade Iraq because we just had to kill some Arabs. We just had to, OK? Something about a bubble or something, too - you had to be there, man, it all made perfect sense. I know it seems weird now, man, but it was this magical time, like the Golden Age of Athens or some shit - The Summer of War! - when we all just knew we were going to change the world. All that stuff our parents told us about Vietnam and all that shit? We were just going to blow that away, man, just tear down their world and build it all up new, like better than ever, like nothing you’d ever seen before! Reynolds was the man, and den Beste was the brains, and everybody was in it together, for freedom and shit. It was great. And the music … well, the music kind of blew, actually. Nickelback was big. And the drugs were pretty crappy. No sex to speak of. But the blogs! Man, you shoulda seen the blogs! Outtasite!

And where are they now? Steven den Beste has stopped illuminating the great cycles of human history, and now writes exclusively about porny Japanese schoolgirl cartoons. Reynolds never got past that summer, never learned how to change with the times, and now he’s Kid Charlemagne. I don’t know what happened to Friedman - he’s behind the Times Select wall now, probably writing about globalization or whatever, or whatever anime den Beste was into 6 months ago. Funny how everyone grew up.

The past really is another country. I would like to bomb it.

The trajectory of some of these neo-con bloggers is noteworthy.

In a related post, a former neo-con invade-Iraq culture warrior blogger virtually flagellates himself and the world of the blogs. I'm ok with the his flagellation, but I think he should have limited his blog-attack to the ones he reads.