Sunday, July 29, 2007

Stories sunk without a trace: Feb 2004 bioweapon scare

I was searching my blog for a post and came across this old story ...
Gordon's Notes: WaPo: Chemical and bioweapon attacks on planes (2/1/2004)

... Intelligence indicating that al Qaeda terrorists are seeking to release a chemical or biological agent aboard an airliner, or transport a radiological device in cargo, was one of the factors that prompted the cancellation of six international flights scheduled for today and tomorrow...
I've long wished newspapers would routinely review stories written 2-5 years ago and tell us how it turned out...

Paying doctors: Room for huge cuts

The New York Times points out that physician reimbursement is one of the reasons that Amerian healthcare is more costly than european (or Canadian, Israeli, etc) health care.

I think they're mostly correct, though the discussion is necessarily simplified. They so point out that the discrepancy is far larger for specialists than primary care, but I think that when one adjusts for differing social costs and workload that primary care physicians in Europe and the US are similarly compensated. The gulf is entirely in the specialties, and particularly the procedural subspecialties (gastroenterology, radiology, etc.). The vastly greater compensation for specialty care in the US has shifted the physician workforce to being largely specialty based, amplifying the total cost to American healthcare. Of course lawyers in the US are probably paid several times as much as European lawyers, but that doesn't change the conclusion.

There's no way to figure out what one should pay physicians because there's no true market in healthcare; the best guide we have is people who pay cash and they tend to be atypically impoverished. It's likely, however, that one could slash US orthopedic reimbursement by 30-40% [1] and still get excellent orthopedic care once the dust settled (though the dust would take years to settle).

There's one point in the article where things went quite wrong however (emphases mine)...
...Dr. Goldman of RAND said that doctors are misleading themselves if they think the current system serves patients’ needs.

For example, if a diabetic patient visits a doctor, he said, “the doctor is paid to check his feet, they’re paid to check his eyes; they’re not paid to make sure he goes out and exercises and really, that may be the most important thing.”

“The whole health-care system is set up to pay for services that are rendered,” he said, “when the patient, and society, is interested in health.”...
I assume Dr. Goldman is not terminally naive, so he must be dissembling. I'm sure his job requires some creative dishonesty, but I wish he wouldn't. There's no real evidence that Americans, or anyone really, is happy shifting healthcare resources from treatment to prevention. Humans simply are not that rational. It's not even close. If Americans were spending their own dime, meaning we had a true healthcare market, I bet we'd spend even less on preventive care than we spend now.

Other than Dr. Goldman's misdirection I agree with the thrust of the article. We could slash healthcare administrative overhead by 70% chop 30% or more off drug costs, and cut procedural/subspecialty reimbursement by 30-40% [1] and still end up with better quality healthcare, by any measure, than we have now. We'd also, with no increase in primary care compensation, end up with a better supply of primary care physicians. The subspecialty offices, however, would have thinner carpets and rattier furniture.

[1] I originally wrote 70%, but that was the result of too quick math. The contrary argument is that, barring continued importation of non-citizen physicians, the US healthcare system is competing for talent with the corporate sector. If US corporate compensation is much higher than European compensation, then that might necessitate higher proceduralist compensation. I don't think that's true however.

The erratic non-progress of the personal information manager

The Personal Information Manager (PIM) has had a difficult 24 years, since Borland's "Sidekick" more or less launched the genre. We're coming up on the 25th anniversary of Sidekick, and I think it's fair to say a geek of 1983 would be shocked by how little progress we've made. The iPhone has no tasks. What more can I say?

The PIM has been a longstanding interest of mine. At various times in my life I've had a pre-web listserv dedicated to the personal information manager, a now-defunct blog dedicated to the Palm and its alternatives and an abandoned web page or two on related topics. I thought of the PIM as I cleaned out some old files, with clippings about (some of these were groupware too) the golden years from 1983-1994. It was in 1994 that the reign of Sauron began.
  • Arabesque's Ecco (much mourned)
  • Lotus Organizer (ok, so it wasn't too fancy)
  • Act for Windows (still around I think)
  • CrossTies (object oriented model)
  • MeetingMaker (cross-platform)
  • Lotus Agenda (a classic)
  • Attain Corp's "In Control": outliner/calendar combination
  • GrandView: calendar/task/outliner/spreadsheet
  • Ascend
  • Commence
  • Arrange 2.0 (Mac - bit of an object oriented database I think)
  • InfoDepot
  • FullContact
  • First Things First (outliner, calendar)
  • NewtonOS: a PIM that was an Operating System
Outlook came later, and the combination of Outlook/Exchange crushed the genre on the PC -- and finished off Palm as well (though by then Palm's owners had shot both feet off). Reinvention continues on the Mac, with a vast array of small vendor products that have various combinations of features of all of the 1983-1994 PIMs. On the web we have Backpack and a range of Web 2.0 apps, most of which will vanish in the next few years. Along with all your data.

Fifteen years ago I thought the salvation of the PIM would be application embedding, what we then thought of as OpenDoc. We'd have applications for projects, tasks, calendars and the like, and they'd all seamlessly interoperate with one another. That was a bit before I got into the interoperability business myself, building applications that tried to talk to one another about lab studies, diseases, genetic history, procedure history, consultations, etc. In that world software is relatively easy, the hard part is "meaning" -- having a common, or at least reasonably interoperable way to represent knowledge about things between systems. It starts with being able to generate a common data model (even if it's only used for communication), but it gets much harder than that when you need to store and create bits of data. That's when you get into really painful things, like formally maintained ontologies. (Engineers love emergent ontologies, which is more like the way our minds work, but interoperability between minds requires more CPU power than we have on the desktop.)

I think the 25 years of non-progress in PIMs springs from the same roots as 25 years of very slow progress in interoperable clinical systems (whether you want them to actually be able to share data is another matter - one of which I've blogged before). The domain of the PIM is far simpler semantically than that of the clinical record, but there's far less pressure for the grindingly hard work of common semantics and mutually agreed upon data models. I think we'll be at roughly the same point in 2033 that were were in 1983 ...

How worthless is the no fly list: 20,000:0 false to true positive

We have long history in medicine of worse-than-useless tests. Tests that produced ten false alarms for every genuine alarm, causing more harm from misguided retesting and treatment than the disease being tested for. The PSA test in men may turn out to be one of those misguided tests; at best it's a borderline test.

I can't recall any diagnostic test in modern medical history, however, that produced 20,000 false positive results and no true positives. I think for a test like that you have to go back to the pre-rational era.

The pre-rational era in which Homeland Security lives today:

Schneier on Security: Terrorist Watch List: 20,000 False Alarms

The Justice Department's proposed budget for 2008 reveals for the first time how often names match against the database, reporting that there were 19,967 "positive matches" in 2006. The TSC had expected to match a far fewer number 14,780. The watch list matched people 5,396 and 15,730 times in 2004 and 2005 respectively.

The report defines a positive match as "one in which an encountered individual is positively matched with an identity in the Terrorist Screening Data Base, or TSDB."..

How do I know they're all false alarms? Because this administration makes a press splash with every arrest, no matter how scant the evidence is. Do you really think they would pass up a chance to tout how good the watch list is?

I've written about this before, often reacting to Schneier's prior posts:
There are two classes of problems with stupidity like this. One is that it causes potential harm to all the false positives, from travel delays to targeted data mining to harassment and false arrest. The other class of problem is that it harms our security. We have only limited resources to use against our enemies, spending them on chasing false leads leaves less for the real work.

    Saturday, July 28, 2007

    Why you may want your child on the third place team ...

    If your child is keen and a strong ball player, you probably want her to join the team that will contend for the championship. On the other hand, if your child is a marginal sportsmen, you may want him on the team that will contend for third place.

    At least that's the conclusion I came to from my first season coaching (assistant/manager) a 10-12 yo ball team. In our league the teams start out reasonably equal (there are some inequalities with pitching that can't quite be eliminated), but at the end of the season there's a wide range of abilities. There are really three major determinants of success -- coaching input, chance (injuries), and natural selection.

    The natural selection bit isn't hard to game. If you drive hard, push a bit, yell a bit, tone down the encouragement, it's not hard to eliminate two or three of the weaker players. If your numbers get too low you get to bring up the very best players from the lower league -- who will play well above the weakest players you gave up. I really doubt this is done consciously; I think these coaches would be profoundly offended if the topic were broached. It's just the way the world works.

    The winning team this year had a superb coach (I've been learning from him) and, as near as I can tell, just this kind of natural selection. I suspect it's a universal rule in all team sports, no matter how egalitarian the league. On the other hand, I think in a league of nine teams a very good coach (better than I am now) can probably contend for third or fourth place with their original squad.

    BTW, the optimization problems of a full-rotation 14 player ball team roster are pretty darned impressive ...

    Friday, July 27, 2007

    Hinduism, Mormonism and more - Fundamentalist America in disarray

    How the mighty have fallen.

    Only seven years after inflicting Cheney/Bush upon the world the American Fundamentalist faces ruin on every front. Gay relationships barely draw notice (do they draw any notice?) in the Twin Cities -- at the very heart of fly-over land. The creationist movement, though far from spent, is in disarray. Polls suggest a dramatic increase in the number of Americans without religious affiliation (though still a smallish minority). Wiccans have their symbols in military cemeteries, and are an identified religious group in the military. Islam has come to Congress. So many evangelical figures have gone down to flames that scandals barely draw notice any more. Perhaps worst of all, current GOP presidential candidates range from incredibly lapsed Catholic (3 marriages?) to a flip-flopping non-Christian.

    Into the ruins comes .... Hinduism [1]. Along with Jains, Hindus challenged the display of the ten commandments in the court (though they lost that fight). Now there've been Hindu prayers in the Senate, six years after Bush's post-9/11 invocations pointedly ignored "non-biblical faiths" and non-faiths:
    Hindu Groups Ask '08 Hopefuls to Criticize Protest - washingtonpost.com

    ... Ante Nedlko Pavkovic, Katherine Lynn Pavkovic and Christan Renee Sugar -- identified in the Christian media as a couple and their daughter -- were removed from the Senate floor and arrested by Capitol Police on July 12 after they began shouting, "This is an abomination," and asking for forgiveness from God...

    ... A brief prayer was then delivered by Rajan Zed, a chaplain from Reno who was invited by Senate Majority Leader Harry M. Reid (D-Nev.).

    Several Christian organizations spoke out against the prayer, before and after it was delivered. The American Family Association circulated a petition, urging its members to contact their senator to protest the prayer. "This is not a religion that has produced great things in the world," it read. The Rev. Flip Benham of Operation Rescue/Operation Save America issued a statement saying the prayer placed "the false god of Hinduism on a level playing field with the One True God, Jesus Christ."...

    ... A focus of the Christian organizations was the perception that Hindus are polytheistic. "Our national motto isn't 'In gods we trust,' " Janet L. Folger, president of Faith2Action, said the day before the Senate prayer.

    However, the U.S. Hindu groups say this criticism reflects ignorance of the monotheistic underpinnings of their faith. Hinduism has many deities, all manifestations of one god.

    According to the foundation, there are 2 million Hindus in the United States.
    Hindusim is monotheistic? Umm, I don't think it's that simple (read the eb article by the way, it's fascinating). Mormonism, Islam (excl Sufism), Judaism, and Christianity are all pretty different theologies -- roughly equidistant from one another in some multi-dimensional doctrinal space. Hinduism is an order of magnitude away from the those four, as are Bahai, Unitarianism, Shinto, etc.

    There's no way to paper over those differences, and they are disastrous for American fundamentalists. The world is moving on, and American politicians want those Hindu, Jain, Bahai, Buddhist, Shinto votes ...

    [1] After reading the EB article it's not clear that "Hindu" is a theologically meaningful label, but I'll stick with it for this post.

    Obesity: correlation, not causation

    Wailing. Gnashing of teeth. Rending of garments.

    That's my reaction to the continuing inability of even semi-informed humans to remember the distinction between correlation and causation, of fully informed specialists to "forget" the distinction ...
    Find Yourself Packing It On? Blame Friends - New York Times:

    .... The answer, the researchers report, was that people were most likely to become obese when a friend became obese. That increased a person’s chances of becoming obese by 57 percent. There was no effect when a neighbor gained or lost weight, however, and family members had less influence than friends.

    It did not even matter if the friend was hundreds of miles away, the influence remained. And the greatest influence of all was between close mutual friends. There, if one became obese, the other had a 171 percent increased chance of becoming obese, too...

    ...Dr. Nicholas A. Christakis, a physician and professor of medical sociology at Harvard Medical School and a principal investigator in the new study, said one explanation was that friends affected each others’ perception of fatness. When a close friend becomes obese, obesity may not look so bad.

    “You change your idea of what is an acceptable body type by looking at the people around you,” Dr. Christakis said....

    Christakis knows better of course, but he also knows how to play the game. He's discovered an interesting correlation in the Framingham data set, and no doubt he thinks he's "controlled" for confounders like education, smoking, socio-economic status, exercise, hobbies, and attitudes towards food. All factors that may play a role in both friendship and obesity (and all of which are affected by genes, which is another topic).

    Grr. If the NEJM had better editors they'd publicly slap the hand of researchers who pretend to be unable to tell the difference between causation and correlation. No wonder the media gets confused.

    We have a long history of studies like this that demonstrate our ability to control for confounders is weak -- no matter what statisticians say. (Why it's weak is an interesting question.) I am very much doubt that a true study (impossible to do), one that randomized people to be "friends" would find any correlation.

    Update 7/27/07: Other variables plausibly correlated with both obesity and friendship include term pregnancy, child rearing, and marital-equivalents. There are likely several others ...

    Thursday, July 26, 2007

    Addiction and disease: My comments on the TIME Science blog

    Here's a fragment from Lemonick's blog post:

    Addiction is NOT a Disease??? - Eye on Science - Science Blog - Michael D. Lemonick - TIME

    A couple of weeks ago, Alice Park and I wrote a cover story about addiction. In it, we kept talking about the fact that addiction is a disease of the brain.

    Silly us. While that's admittedly the view of the National Institute on Drug Abuse and the vast majority of addiction specialists, we forgot to talk to Sally Satel and Scott Lilienfeld. If we had, we would just have said "never mind." Yesterday, this dynamic duo published this essay at Slate.com, in which they set the record straight.

    Satel and Lilienfeld, a psychiatrist and a psychologist, respectively, explain that addiction is no disease. It's a habit. "But like other bad habits," they write, "it can be broken." Which is to say, it's kind of like picking your nose in public, evidently, except that it's more expensive...

    And here's my comment:

    This is a deeper topic than you're suggesting. The past twenty years of neuroscience have been putting a tighter and tighter box around what "free will" can be. Much of what we are and do is determined by our genes, and the rest is pretty much set in-utero (the primary environmental component). The next 5-10 years may add another 10-15% of variation, and we don't have much control over that, do we?

    After age 10 we're pretty much on cruise control -- or so it seems.

    So the contrarians aren't really arguing about addiction, they're arguing about the fundamental basis of responsibility. If all we are and do is determined by our genes and uterine residence, then what does punishment mean?

    So their arguments are nonsensical, but their anxiety is completely understandable. If our civilization survives I am reasonably certain that within 40 years our concepts of punishment and responsibility will be dramatically different.

    Torturers may not sleep well ...

    Libya imprisoned and tortured innocent people because they were convenient scapegoats for a disastrous HIV outbreak. Libya received a $400 million ransom to free them.

    The torturers, however, may not always sleep so well ...
    Freed medics describe Libyan captivity - International Herald Tribune

    ...Asked if they were ready to testify in a Bulgarian court in a future case against her torturers, Valcheva said calmly, 'Yes, we are ready.'
    The courts will grind on. One day, a small semblance of justice will be done.

    I wonder if Cheney ever thinks about the day he gets off a plane in Germany and finds handcuffs waiting for him ...

    Wednesday, July 25, 2007

    Please don't buy an iPhone. Yet.

    Apple's iPhone may not have launched quite as well as Apple might have hoped. I like that. Apple is more likely now to second guess some of their mistakes, like a headphone jack that, for no sensible reason, doesn't fit most headphones. Maybe they'll even create a task list, enable notes synchronization, open the phone to signed Cocoa apps, put FileMaker Mobile on the phone, provide synchronization to Google Calendar, fix the broken Outlook synchronization (255 character contact notes?!?!) etc, etc.

    On other side of the iPhone equation, AT&T may rethink pricing, and in particular rethink how much an iPhone is worth given their weak coverage and demonstrably slow and unreliable data support.

    So if you've been thinking of buying an iPhone, please hold off a bit. I very much want to buy an iPhone, but I want Apple and AT&T to suffer enough to bring it a bit closer to what I need. (Voice dialing and GPS wouldn't hurt either, but I can live without them.) If you're still feeling tempted, contemplate this list of iPhone v1.0 Bugs (AppleHound). There, don't you think you can wait another three to five months?

    You can wait a bit longer ... really. Apple's got tons of cash -- they're not going away. We just want them to suffer a bit. Heck, if the share price drops 20% you can make a good investment too ...

    Iraqi feelings theoretically meaningful?

    The very latest research suggests to some that Iraqi feelings should be treated as meaningful, even human ...

    Study: Iraqis May Experience Sadness When Friends, Relatives Die

    CHAPEL HILL, NC— A field study released Monday by the University of North Carolina School of Public Health suggests that Iraqi citizens experience sadness and a sense of loss when relatives, spouses, and even friends perish, emotions that have until recently been identified almost exclusively with Westerners.

    "We were struck by how an Iraqi reacts to the sight of the bloody or decapitated corpse of a family member in a not unlike an American, or at the very least a Canadian, would," said Dr. Jonathan Pryztal, chief author of the study...

    ... "We are, in truth, still a long way from determining if Iraqis are exhibiting actual, U.S.-grade sadness," Mayo Clinic neuropsychologist Norman Blum said. "At present, we see no reason for the popular press to report on Iraqi emotions as if they are real."

    The Onion has produced another bitter classic. I would applaud any newspaper that routinely followed "3,500 US dead" with "and over 300,000 Iraqi dead" .... (Thanks FMH)

    Monday, July 23, 2007

    Let us not mention this to our space alien visitors ...

    There's really no need to bring up this sort of thing ...
    Damn Interesting: The Thugs of India

    ...Their extreme secrecy combined with their mastery of murder made the Thugs the deadliest secret society in all of history. In the early 19th century they were credited with 40,000 deaths annually, stretching back as far as anyone cared to count. Some estimates put the overall death toll as high as 2,000,000, but with the cult potentially operating for more than 500 years before formal records were kept, the true number is impossible to determine.

    Sunday, July 22, 2007

    Flatline - escaping the hideous smiley face of junk

    I remember the hideous smiley faces of the 1970s. For years they haunted boomer dreams, but now we're trapped in the pit of the smile, deluged in cheap junk that's worth less than nothing ...
    Gordon's Notes: Riding the dragon - Fallows on China

    James Fallows .... The curve is named for the U-shaped arc of the 1970s-era smiley-face icon, and it runs from the beginning to the end of a product’s creation and sale. At the beginning is the company’s brand: HP, Siemens, Dell, Nokia, Apple. Next comes the idea for the product: an iPod, a new computer, a camera phone. After that is high-level industrial design—the conceiving of how the product will look and work. Then the detailed engineering design for how it will be made. Then the necessary components. Then the actual manufacture and assembly. Then the shipping and distribution. Then retail sales. And, finally, service contracts and sales of parts and accessories.

    The significance is that China’s activity is in the middle stages—manufacturing, plus some component supply and engineering design—but America’s is at the two ends, and those are where the money is. The smiley curve, which shows the profitability or value added at each stage, starts high for branding and product concept, swoops down for manufacturing, and rises again in the retail and servicing stages. The simple way to put this—that the real money is in brand name, plus retail—may sound obvious, but its implications are illuminating....

    So how can one escape the smile and restore "balance to the force"? One approach is fundamentally Darwinian. Strong brands invest in defect analysis and early detection, eliminating suppliers who deliver flawed product. Consumers forget about commodity products and invest in brands. Consumers miraculously develop a memory for what brands fail...

    Oops. The memory part is the problem. Do you remember what companies had melamine in their dog food? Do you think you'll remember a year from now? Diethylene glycol in the dime store toothpaste? The DVD player that broke after one month? The wireless home phone that always crackled? The noisy fan, the sloppy wrench, the flimsy toaster ....

    What other strategies are there? How else can the curve be balanced between design, brand, manufacturing and retail? How can costs be shifted from retail and brand to invest in better manufacturing and design -- anywhere?

    I think we need to look for new options. What if an insurance company were to provide insurance policies guaranteeing devices performed to spec on delivery and for two years post sale? The policy would include a large rider to cover recalls, including a prize to anyone who found a recall qualifying defect. Anything that qualified for coverage would be able to display an appropriate and meaningful "seal of approval". Consumers could choose to get the insurance or not, some might decide the "insurable" measure was enough by itself. Vendors would, of course, have to pay for the "seal".

    Perhaps this would produce a kind of "meta-brand", allowing manufacturers to outsource branding and shift investments to design and manufacturing - flattening the hideous smiley.

    Saturday, July 21, 2007

    Dyer: Five new essays

    Dyer has five new ones:
    2007

    July 1 Perspectives on Terrorism
    July 3 The United States of Africa
    July 6 The End of Cheap Food
    July 10 The New York Times vs. Reality
    July 14 North Korea: Five Wasted Years
    I'm puzzled Dyer doesn't have a larger blog profile. It's true that his web technology is medieval, but I suspect it's simply a lack of big name attention. Now if Brad were to start reading Dyer ...

    The best time to buy a plane ticket

    Buy your plane tickets on a Wednesday ...
    The Big Picture | The Cheapest Days to Buy Certain Items

    Great article in Smart Money that fits in well with recent Retail Day: how and why certain pricing strategies occur...

    Airplane Tickets
    When to Buy: Wednesday morning.
    Why: 'Most airfare sales are thrown out there on the weekend,' says travel expert Peter Greenberg, a.k.a. The Travel Detective1. Other airlines then jump into the game, discounting their own fares and prompting further changes by the first airline. The fares reach their lowest prices late Tuesday or early Wednesday....
    Of course if everyone were to follow this advice the advice would become worthless ...