Thursday, August 23, 2007

You can't fly with your eyes closed - at all

I thought I new most everything, but I didn't know this ...
James Fallows (August 21, 2007) - Aerodynamics 101 (following JFK Jr crash discussion)

...No one who has received an instrument rating in an airplane doubts any of the above, because as part of the training everyone has been through this exercise: When the plane is safely several thousand feet in the air, the instructor will tell the trainee pilot to close his eyes and keep flying the plane. He is supposed to keep it level just by feel.

Within sixty seconds or so, the instructor crisply says "my airplane" and takes control again. The trainee pilot opens his eyes and is startled to see the ground coming up toward him, since the plane is spiraling* down. This always happens when the plane is flown blind, it usually happens very quickly, and generally the eyes-closed pilot had no physical sense that anything was wrong. This process is what tragically kills most pilots without instrument training when they unexpectedly enter a cloud; having no visual cue to what is up and down is the same as wearing a blindfold. It is also what is assumed to have happened to poor John Kennedy Jr and his passengers, in the dark and fog over the water.
It's the same reason you can pour tea more or less correctly in a plane flying upside down -- they're designed to keep the "floor" in place (meaning, of course, that you're losing altitude pretty fast ...)

Bane of the net: who maintains those pretty web sites?

You're a local official and you need a web site. You scrape up a budget, find someone who can put one together, and you're done.

Except things change. Thinks like, you know, schedules. Then you rediscover what everyone who's ever built anything learns.

Maintenance is a drag. It's not funded. It can be expensive. Pretty things may be much more expensive to maintain. That hand-crafted web site can't be updated without ... yes ... the original developer.

Not to pick on anyone, but this is typical:
Lake Wobegon Trails - Hiking, Biking, Walking, Blading, Skiing, Snowmobiling

We are working on an updated listing for 2007. Dates shown as 2006 dates will probably be very near the same dates for 2007....
It's August 2007 now. They're a bit behind.

Small businesses, schools and non-profits ought to choose for ease of maintenance, not for the initial product. The ideal solution should manageable by any high school graduate, but there's nothing like that on the market.

For MN Special Hockey I cobbled together a combination of Google Apps, Google Custom Domain, Google's Page Creator, Google Docs and Google/Blogger. It was very hard to setup, it's quarter-baked, and only a true geek is going to be able to tweak the overall configuration -- but I hope non-specialists will be able to post news (blogger), and even edit the main pages (Page Creator, note it requires admin access to do any page edits). If Google Apps ever get sorted out they could turn into a pretty good solution.

Content management systems try do something similar. They require experts to configure initially, but basic updates may require less expertise. In practice, however, these seem to run into considerable maintenance issues.

Another approach is to leverage "web 2.0" solutions. This is still emerging, but one way for the Lake Wobegon trail team to cost-effectively update their feeble map would be to replicate it in Google Maps and send out four bicyclists with cameras. Create the map as free custom content in Google Maps, upload photos to a free Picasa album, comment on the photos as needed, and lay them out on the trail map. Now link to the Google map and expect other users to add to it.

Lastly there's the combination of Apple's iWeb and Apple's dotMac (.mac) services (now support custom domains). Apple's can be an unreliable partner, but this might hit the usability requirement. The catch, other than Apple pulling an 'iMovie' (replacing a high end product with dumbed-down solution under the same brand), is that this requires OS X. On the other hand, if you can't afford website maintenance you definitely can't afford to maintain XP (bad) or Vista (worse). There are a few like solutions in the OS X world, I'm not aware of any in the XP world. (FrontPage once owned that space, but Microsoft abandoned it years ago.)

Google Maps: sort of display Picasa photos

Ooops. This was posted here by accident. The real one is here (Gordon's Tech).

Sorry!

Physicist bloggers getting cranky

I read a few physics blogs, and lately I think I'm seeing a bit of irritability. CV (Sean)'s post today hints at the trend ...
Ask a String Theorist! Or an Atomic Physicist. | Cosmic Variance.

..Aaron has begun to talk a little about the multiverse — here, here. He has thereby earned grumpy mutterings, rolled eyes, and “help” from some sensible physicists, some crackpots, some curmudgeons, his guest co-blogger, and even himself. I don’t quite understand what all the angst is about...
Bio-blogger crankiness is usually related to creationists. Creationists seem to leave physics alone (an interesting phenomena); the "crank" and the "crackpot" are the bane of physics bloggers. I think biologists have a legitimate complaint, but physicists protest too much. In the case of physics, the cranks have a case.

It's not that cranks are a good guide to physics, it's rather that physics is so weird that to an outsider the cranks are hardly less plausible than the science. Entanglement across the multiverse? Seems almost plausible.

It doesn't help that by nature and practice physicists are driven to contemplate the forbidden. Tests for "life in a simulation"? Answers to the Fermi Paradox? Rules for the least harmful use of the Bayesian anthropic principle (ok, so maybe the creationists do show up)? Physicists can't stay away -- but the very questions make even them irritable. Cranks like me only darken their mood.

Relax gang. Ignore your cranks and embrace your fundamental weirdness. It's a weird universe, and the crackpots are at home ...

Monday, August 20, 2007

A carbon tax PAC: the most effective form of greenery

I added this comment to Kristof's blog following his "conservation is good" NYT OpEd:

Energy Conservation - Nicholas D. Kristof - Opinion - TimesSelect

Conservation = Carbon Tax.

It's a fairly simple equation. I'm disappointed that you chose not to mention it. I understand it's probably wise to let people slowly draw their own conclusions, but it is a bit dishonest.

You know perfectly well that the only way to accelerate conservation is by an overt carbon tax or by a hidden tax (regulatory mandates).

To that end, I'd like to see a "carbon tax PAC" that we could all contribute to. It makes far more sense to send $25 to a "carbon tax PAC" than to spend $25 on a low energy light bulb.

Perhaps you're constitutionally opposed to taxation. That's where we can negotiate. I'm ok with shifting funds, so the revenue raised through a carbon tax is offset by cuts on capital gains, increasing personal exemptions, increasing EITCs, etc.

Suddenly Vista has no friends

First Coding Horror was down on Vista. Then James Fallows ripped it off his laptop. Then the editor of PC Magazine declared Vista a disaster -- even as he left his job.

The harshest blow, however, comes from Joel on Software: "I've been using Vista on my home laptop since it shipped, and can say with some conviction that nobody should be using it as their primary operating system -- it simply has no redeeming merits to overcome the compatibility headaches it causes. Whenever anyone asks, my advice is to stay with Windows XP (and to purchase new systems with XP preinstalled)."

Joel remembers his Microsoft days fondly, so his words sting. Vista is, apparently, a mess. We can expect others to pile on now. Given the current mess it may be another year before Vista is ready for use.

I share Joel's opinion on Office 2007, with the caveat that Word is probably better and Excel wasn't hurt too much. I've figured out the UI now but it was a pain to learn it.

Great news for OS X. BTW, I don't expect 10.5 to ship until next summer. With Vista tanking the pressure is off Apple, and 10.5 is not looking very solid yet. They'll quietly slip it from this October into next spring, and maybe roll some 10.5 features back into 10.4.

Sunday, August 19, 2007

Easy primary care research project: good for fellowship, residency etc

I don't do clinical research any more, but occasionally I come across questions that might produce a cheap, interesting and publishable study.

Here's one.

What percentage of parents run out of their child's liquid antibiotic medication prior 24 hours early? My guess is that the percentage is over 70% due to normal loss, spillage, and over accurate dispensing.

Simple study, publishable unit.

For extra credit, what are the financial incentives for "precise" dispensation of liquid antibiotics?

Friday, August 17, 2007

Giuliani - time to go away. Please.

Really. It's time to quit. Actually, it's time to have never started.

Rudy Giuliani's loopy foreign-policy statement. - By Fred Kaplan - Slate Magazine

Rudy Giuliani's essay in the latest issue of Foreign Affairs, laying out his ideas for a new U.S. foreign policy, is one of the shallowest articles of its kind I've ever read. Had it been written for a freshman course on international relations, it would deserve at best a C-minus (with a concerned note to come see the professor as soon as possible). That it was written by a man who wants to be president—and who recently said that he understands the terrorist threat "better than anyone else running"—is either the stuff of high satire or cause to consider moving to, or out of, the country...

...Two months ago, when Giuliani issued some of his first pronouncements on foreign policy, I wrote that he is "that most dangerous would-be world leader: a man who doesn't seem to know how much he doesn't know." Judging from his Foreign Affairs article, the breadth and depth of his cluelessness are vaster than even I had imagined.

Kaplan, in other words, is shrill. The GOP candidates are having that effect on a lot of people.

Gwynne Dyer - 9 essays - July through Aug 16 2007

Dyer has 9 new ones.

  1. Bangladesh: When Democracy Goes Bad
  2. The Turkish Election
  3. Libya, Bulgarians and Lockerbie
  4. Oil: $100 a Barrel -- or $200?
  5. Zimbabwe Meltdown
  6. Pakistan: Forecasts of Disaster
  7. Arctic Scramble
  8. Slow Forward
  9. "Boys Go To Baghdad..."

I'm convinced now he'll never add a syndication feed or otherwise update the web site. I think his may be the last site in the world serving "pages" as .txt files. I assume that's not a clever technique to prevent blogging/quoting, but you never know -- he may be curmudgeonly, but he's a very good writer.

Anyway, I've added a Dyer tag to Gordon's Notes -- if Blogger adds tag-specific RSS it will become a de facto Dyer feed.

The Apple iMovie debacle: Pogue smacks 'em

Pogue is a longtime Apple user, author, and informed fan. So this smackdown might get noticed in Cupertino (emphases mine) ...
Apple Takes a Step Back With iMovie ’08 - Pogue’s Posts - Technology - New York Times Blog

... To rephrase (and sanitize) the wailing on the discussion boards: What the [bleep]! What was Apple thinking?

Apple says that it was thinking: “It’s 1.0. We’ll bring it up to par with free software updates, like we always do.” Internally, I’m guessing that it was also thinking, “iMovie had gotten pretty old, and it was haunted by some intractable bugs.” And also, perhaps, “iMovie was getting so powerful, it was taking sales away from Final Cut.

But it must also have been thinking, “Then again, it is a little embarrassing to take so many steps backward.”

That’s why, with what I imagine is a certain degree of sheepishness, the company is offering a free download of the previous iMovie version to anyone who has iMovie ‘08. In that regard, all the wailing is a bit overblown; Apple is not actually taking away the older version. The only real raw part of the deal is that people who pay $80 for a new software rev expect an enhanced version—not another copy of the old one.

I can’t remember any software company pulling a stunt like this before: throwing away a fully developed, mature, popular program and substituting a bare-bones, differently focused program under the same name.

I’ve used the real iMovie to edit my Times videos for three years now. The results are perfectly convincing as professional video blog work. But the new version is totally unusable for that purpose. It’s unusable, in fact, for anyone doing professional work that requires any degree of precision...
Apple's historic danger is getting drunk with arrogance. That's why we Apple customers love them to feel the blistering heat of competition -- it keeps 'em sober. The iMovie story tells me they've fallen off the wagon again -- but the rapid release of the 'free version' (I've read anyone can get it) suggests they might be back in rehab. Maybe.

I don't buy the 'continual free upgrades' to iMovie_II 1.0 though -- Apple's been saying they can't do free function upgrades any more without charging for 'em (accounting rules).

My money is on the 'protect Final Cut' answer. I think that's the same reason Apple won't provide Library management (import/export Libraries) for iPhoto.

Thanks Pogue. Please kick Apple again for us. Harder.

Alas, what's really needed is more competition for iLife, and I'm afraid there's nobody likely to do that. Apple has pulled far enough ahead that they can do things like this and still have the best solutions for any platform.

Pigs teleport

Fallows finds a WSJ OpEd that's not stupid and David Brooks says something sane.

Ok, so maybe the hand of Sauron is behind the WSJ OpEd and maybe Brooks respectful comments on John Edwards are an attempt to sabotage the Dems. Even so, the pigs aren't just flying today...

Thursday, August 16, 2007

The history of amphetamines in America

It's surprisingly hard to find the history of drugs in the medical literature -- Dexedrine, Benzedrine, Norodin and the like don't show up in today's reference books. So I appreciated this Salon book review summary, but I found it confusing -- on first reading I thought they were claiming that Benzedrine was methamphetamine! I've added some clarifications in square brackets.

The highs and lows of methamphetamines

... The synthetic methamphetamine has a horticultural analog in ephedra vulgaris, used for millennia by the Chinese as an herbal remedy for asthma and other breathing ailments. In 1887, a Japanese scientist identified ephedra's active ingredient, ephedrine, a chemical similar to adrenaline. The same year, the German L. Edeleano used ephedrine as the base to create phenylisopropylamine, now known as amphetamine.

But because the substance seemed to have no useful medical applications, the malign genie remained in the bottle until the 1920s, when ephedrine was first used to treat asthma in clinical trials in North America and Europe. Meanwhile, a Japanese scientist developed a more powerful synthetic version of the drug that came to be known as methamphetamine [d-desoxyephedrine]. In 1927, a British research chemist at UCLA named Gordon Alles resynthesized Edeleano's drug [amphetamine sulfate] for use as a bronchodilator, and subsequently sold the formula for use as an over-the-counter inhalant.

The new drug, christened Benzedrine [amphetamine sulfate], was initially marketed as a miracle cure, "used to treat obesity, epilepsy, schizophrenia, cerebral palsy, hypertension, 'irritable colon,' 'caffeine mania,' and even hiccups." By the 1950s, variations on its chemical theme included Dexedrine [dextroamphetamine sulfate], whose "gentle stimulation will provide the patient with a new cheerfulness, optimism, and feeling of well-being"; Norodin [?], "useful in reducing the desire for food"; Desoxyn [methamphetamine], for "When she's ushered by temptation"; and Syndrox [?], "For the patient who is all flesh and no will power."

All these testimonials originated in medical journals, and the drugs were targeted at women, mostly as "pick-me-ups" and diet aids. But even prior to the 1950s, amphetamine and methamphetamine had begun to leave their mark upon the American heartland. During World War II, factories at the San Diego naval base provided troops overseas with Benzedrine. Owen claims "GIs consumed an estimated 200 million pills," causing untold numbers of soldiers to return stateside with an amphetamine habit...

Methamphetamine was sold as Methedrine and Desoxyn in the US -- and administered to Japanese industrial workers to increase productivity, I can't figure out what Norodin and Syndrox were, but I'm willing to believe they were also methamphetamine.

While trying to figure this out I came across references like this one ...

THE BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE

Charles Bradley M. D. Am J Psychiatry 94:577-585, November 1937

The psychological reactions of 30 behavior problem children who received benzedrine sulfate for one week were observed. There was a spectacular improvement in school performance in half of the children. A large proportion of the patients became emotionally subdued without, however, losing interest in their surroundings...

Well, there had to be something before Ritalin. [Update 8/17: I'm a bit behind on my sleep. Adderall, which is in use today, is amphetamine-dextroamphetamine. So this was probably one of the first studies of what is now sold as Adderall. When I came across this out of context, I was shocked by the study. In my case, the reaction is noteworthy.]

I'm sure methamphetamine was very effective as a weight loss pill. It would be interesting to know the stories of the women who used Desoxyn for weight loss in the 1950s. Many should be living today. How did their stories compare to the meth addicts of the modern era?

Wednesday, August 15, 2007

Levitt on terrorism

Steven Levitt now blogs for the NYT. In a burst of misplaced enthusiasm he channeled Schneier and blogged on how to give terrorist great new ideas. I'm not sure this is a great idea when Schneier does it, but Levitt ought to leave this kind of thing to the pros.

Why am I a bit uneasy? After all, I've probably done the same sort of thing at one time or another. My unease comes because I worry that there's a reasonable number of fairly dull would-be terrorists out there. The pros (Hamas, the former IRA, etc) don't need ideas, but the dimwits probably appreciate 'em. I'm only a "bit" uneasy though, even the dimmest terrorist has an infinite amount of material to work from.

So why don't they do more, and can we really do much about it? In a better column Schneier digs deeper ...

Terrorism, Part II - Freakonomics - Opinion - New York Times Blog

... Like the British and Israelis have done, if faced with this situation, Americans would figure out how to live with it. The actual cost of this low-grade terrorism in terms of human lives is relatively small, compared to other causes of death like motor-vehicle crashes, heart attacks, homicide, and suicide. It is the fear that imposes the real cost.

But just as people in countries with runaway inflation learn relatively quickly to live with it, the same happens with terrorism. The actual risk of dying from an attack while riding a bus in Israel is low – and so, as Gary Becker and Yona Rubinstein have shown, people who have a lot of experience riding Israeli buses don’t respond much to the threat of bombings. Similarly, there is little wage premium for being a bus driver in Israel....

....it strikes me that there are two possible interpretations of our current situation vis-à-vis terrorism.

One view is the following: the main reason we aren’t currently being decimated by terrorists is that the government’s anti-terror efforts have been successful.

The alternative interpretation is that the terror risk just isn’t that high and we are greatly overspending on fighting it, or at least appearing to fight it. For most government officials, there is much more pressure to look like you are trying to stop terrorism than there is to actually stop it. The head of the TSA can’t be blamed if a plane gets shot down by a shoulder-launched missile, but he is in serious trouble if a tube of explosive toothpaste takes down a plane. Consequently, we put much more effort into the toothpaste even though it is probably a much less important threat.

Likewise, an individual at the CIA isn’t in trouble if a terrorist attack happens; he or she is only in trouble if there is no written report that details the possibility of such an attack, which someone else should have followed up on, but never did because there are so many such reports written.

My guess is that the second scenario — the terrorism threat just isn’t that great — is the more likely one...

Preventive care - a marginal idea?

I've suspected this was true for about 18 years:
NYT Leonhardt - Free Lunch on Health Care ...

... Jay Bhattacharya, a doctor and economist at Stanford’s School of Medicine, estimates that to prevent one new case of diabetes, an antiobesity program must treat five people — “not cheaply,” he says. Along the same lines, Mr. Gruber found that when retirees in California began visiting their doctor less often and filling fewer prescriptions, overall medical spending fell. People did get sick more often, but treating their illnesses was still less costly than widespread basic care — in the form of doctors visits and drugs. Louise Russell, an economist at Rutgers, points out that programs that focus on at-risk patients cost the least, but even they are rarely free.

As Dr. Mark R. Chassin, a former New York state health commissioner, says, preventive care “reduces costs, yes, for the individual who didn’t get sick.”

“But that savings is overwhelmed by the cost of continuously treating everybody else.”

The actual savings are also not as large as might at first seem. Even if you don’t develop diabetes, your lifetime medical costs won’t drop to zero. You might live longer and better and yet still ultimately run up almost as big a lifetime medical bill, because you’ll eventually have other problems. That would be an undeniably better outcome, but it wouldn’t produce a financial windfall for society.
I don't know if it's an urban legend, but I read over a decade ago that Japan's finance ministry blocked anti-smoking programs because the led to high social security costs. The new addition is that preventive care is not economically efficient because it's not targeted. Presumably, if you could target preventive care more effectively (genomics, patient readiness to change) you'd get more value. Of course if a "pay for performance" program tracks preventive care metrics ...

It's often cheaper to cure than to prevent.

One caveat is that for the informed individual, preventive care makes LOTS of sense. It's only a marginal investment from a societal perspective. Another caveat is that this the research doesn't apply to immunization programs, it was looking at programs that advocate behavioral change.

How toy makers can save themselves

Toy makers are worried ....
Toy Makers Brace for a Chill in Sales - New York Times

...Meantime, toy makers are trying to prove to lawmakers that they can handle the matter themselves. Carter Keithley, the president of the Toy Industry Association, called tests at ports of entry “belt and suspenders checks,” arguing that such a measure would be overly cautious....
There's an easy way for toy makers to reassure the public. They can offer a $10 million prize to anyone who finds a problem that leads to a recall.