Monday, September 12, 2005

Diminished responsibility: the next cultural battleground

My wife and I were chatting about the genetics of cognition when conversation turned to one of the great emotional touchstones of the conservative momement -- "individual responsibility"

My wife tells me of a conversation she had with a neuroscientist who studies brain maturation in adolescents. After the neuroscientist explained about the extraordinary transformations and faults of the adolescent brain, my wife remarked on the obvious connection to diminished responsiblity. The scholar was appalled "but they are still responsible for their actions ...". My wife, who is far nicer than I, changed the subject.

Like much conservative language "individual responsibility" is best understood as a denial rather than an affirmation, in particular it is a denial of the concept of 'diminished responsibility'. Republicans hate the idea that age, brain maturation, retardation, or other disorders of cognition should in any way mitigate punishment. This is why, for example, they are keen to execute children (ok, teenagers). If one treats children differently from adults, then why not hold retarded adults to a different standard than average adults? The age exemption is a big step down a slippery slope to the terror of relativism.

But what are the roots of this terror? I'm not sure. There is, however, a theological component. If humans can see that a person's responsibility may be diminished in proportion to their consciousness, then could a deity do no less? Who then, would ever go to Hell? Either no-one goes, or as CS Lewis suggested -- God judges each person on the basis of what they did with what they were given. If that were so, many New Orleans looters could bask in paradise, and many born-again Republicans whither in damnation.

Scary thought indeed.

Sunday, September 11, 2005

The evolution of the human brain: ASPM, microcephalin and FOXP2

First the article summary, then the discussion.
The Globe and Mail: Is your mind changing? Scientists think so

In two papers published today in the journal Science, Dr. Lahn and his colleagues report that the specific gene mutations they have found appear to have swept across certain areas of the globe so quickly that they are practically the norm. With prevalence rates higher than 70 per cent in Europe, for example, the researchers argue that chance alone cannot explain the changes, which first sprung up at the same time that modern humans developed culture and language...

...Testing 1,184 DNA samples from around the world, the researchers found, for example, that the frequency in West and sub-Saharan Africa is less than 10 per cent...

...They found that a particular series of mutations in the microcephalin gene appears to have been passed on and is now, surprisingly, carried by large numbers of people from different ethnic backgrounds. They estimate this series first emerged about 37,000 years ago, around the time modern humans settled Europe and began producing art.

The changes they found in the ASPM gene are far more recent, springing up about 5,800 years ago, coinciding with the rise of cities and the first record of written language.
This is one in a series of fascinating findings over the past few years, but the research is only beginning. I've blogged previously on the ASPM gene (it's undergone many mutations compared to chimps) and the timing of language and alleged gene relationship (including FOXP2), most recently there was the Ashkenazi IQ article.

The timing of the most recent alleged ASPM mutation is new to me. The African/European gene frequency data is a wee bit controversial, in almost all genetic measures, however, there's a lot more variation in Africa than Europe (founder effect).

This is new science, and we know that about half of the conclusions of major studies are reversed within 5-10 years. It's premature to put too much weight on it. I do suspect, however, that science will tell us that potential IQ is related to only a handful of genes, that we'll learn that all human brains have an extremely high defect rate, and we'll learn that our notions of 'responsibility' are based on faith rather than evidence.

I also agree with the researchers that people will pay a great deal to increase the intellect of their offspring -- more than they'll pay to make them tall or pretty or long lived. I think deliberate manipulation rather than natural selection will drive further changes to these genes.

Update 9/15: The ASPM variant is about 5700 years old. Amerindians crossed into the Americas at least 10,000 years ago. It turns out that virtually no Amerindians had this gene.

Saturday, September 10, 2005

Distemper and the death of the american dog

I was sure I'd blogged on this years ago, but I can't find anything. Odd. (Update 7/11/13 - it was 11/2004)

The point of this blog is to discuss the possibility that distemper wiped out the native american dog as it's doing in the african dog. First the back-story. This article is a good place to start:
Humans Brought Domesticated Dogs to New World More Than 12,000 Years Ago, UCLA Biologists, Colleagues Report

... these data suggest Native American dogs have not genetically contributed to modern dog breeds,' Wayne said. 'DNA sequences from hundreds of dogs from dozens of modern breeds from throughout the world do not show traces of American ancestry. Native dogs may still have living descendants in some unsampled New World population, but their absence for a large sample of modern dogs reinforces the dramatic impact that the arrival of Europeans had on native cultures.
This UCLA article focuses on research showing early Americans traveled with dogs into the new world over 12K years ago, but it also mentiones that native American dogs died out shortly after the Euro invasion.

Why do the Native dogs disappear? I don't buy the explanation of selective breeding. Dogs ain't picky and I can't believe early American practiced rigorous canine birth control. It had to be the canine equivalent of smallpox -- a disease that was nasty and prevalent in the crowded swamp of industrial europe but was lethal in the healthy empty world of the americas. But what disease?

I'd guess distemper. Recently I read that wild African dogs are now dying of epidemic distemper. Seems to fit. The Euros carried viruses that killed many of the native americans, it's not surprising that their dogs would have done the same thing.

PS. Humans and dogs have coexisted for a long time, it is extremely likely that we have altered each other's evolution (symbiotes and parasites always alter each other's genome). BTW, I thought I'd blogged on my wild speculation that it was the domestication of dogs that allowed humans to develop technology and agriculture (geeks and women can domesticate dogs and use a powerful and loyal ally to defend themselves against thuggish alphas) -- but I can't find that either. Sigh. Aging brain.

Update 7/11/2013: Years after I wrote this I suspected it was wrong. After all, wolves weren't wiped out, and dogs and wolves interbreed. More recent studies show that the pre-Columbian dogs were not completely replaced. Their mortality may resemble that of pre-Columbian humans of the new world. I still wonder about the distemper/measles connection.

See also:

The NYT Magazine reviews the war on terror

Taking Stock of the Forever War - New York Times
'Declaring war on 'terror,'' as one military strategist later remarked to me, 'is like declaring war on air power.'
A superb quote. The title of the article is taken from a famous science fiction story. This article is required reading for all citizens.
Four years after the collapse of the towers, evil is still with us and so is terrorism. Terrorists have staged spectacular attacks, killing thousands, in Tunisia, Bali, Mombasa, Riyadh, Istanbul, Casablanca, Jakarta, Madrid, Sharm el Sheik and London, to name only the best known. Last year, they mounted 651 "significant terrorist attacks," triple the year before and the highest since the State Department started gathering figures two decades ago. One hundred ninety-eight of these came in Iraq, Bush's "central front of the war on terror" - nine times the year before. And this does not include the hundreds of attacks on U.S. troops. It is in Iraq, which was to serve as the first step in the "democratization of the Middle East," that insurgents have taken terrorism to a new level, killing well over 4,000 people since April in Baghdad alone; in May, Iraq suffered 90 suicide-bombings. Perhaps the "shining example of democracy" that the administration promised will someday come, but for now Iraq has become a grotesque advertisement for the power and efficacy of terror.
The author off-handedly points out that we've lost the Iraq war we started, and, incidentally, so have the Iraqi people. I'm not sure history will indict Bush for the decision to invade Iraq -- though I suspect it will. I am sure, however, that he will be indicted for not firing Rumsfeld and moving Rove aside.
The sun is setting on American dreams in Iraq; what remains now to be worked out are the modalities of withdrawal, which depend on the powers of forbearance in the American body politic. But the dynamic has already been set in place. The United States is running out of troops. By the spring of 2006, nearly every active-duty combat unit is likely to have been deployed twice. The National Guard and Reserves, meanwhile, make up an unprecedented 40 percent of the force, and the Guard is in the "stage of meltdown," as Gen. Barry McCaffrey, retired, recently told Congress. Within 24 months, "the wheels are coming off." For all the apocalyptic importance President Bush and his administration ascribed to the Iraq war, they made virtually no move to expand the military, no decision to restore the draft. In the end, the president judged his tax cuts more important than his vision of a "democratic Middle East." The administration's relentless political style, integral to both its strength and its weakness, left it wholly unable to change course and to add more troops when they might have made a difference. That moment is long past; the widespread unpopularity of the occupation in Iraq and in the Islamic world is now critical to insurgent recruitment and makes it possible for a growing insurgent force numbering in the tens of thousands to conceal itself within the broader population.

Friday, September 09, 2005

Finally -- blogger knows BlogThis is broken.

It took about 5 email exchanges but Blogger now understands the BlogThis! bug and acknowledges it.

They really need to improve the way they process bug reports. This was a 100% trivially replicable bug and it must have affected thousands of users; but it took over 3 weeks for them to understand it. It turns out that it probably impacts everyone who enables title and URL display in their blogs.

Thursday, September 08, 2005

Specialization and the wealth of nations

Econbrowser provides a pithy summary of what makes countries wealthy: specialization.
Econbrowser: On the nature of economic recessions

The level of prosperity in an advanced economy results from a high degree of specialization of labor, capital, and most importantly, the institutions (shops and firms) that coordinate their activities. What happens in an economic recession is that the market's success at coordinating this specialization breaks down. Firms and workers suddenly find that the activity for which they are uniquely suited is no longer in demand, and the degree of specialization makes it infeasible to redirect these productive inputs immediately to other sectors. These sudden demand shifts can occur, for example, if sharp energy price changes and the uncertainty accompanying them produce dramatic changes in consumers' purchases of items such as cars.
Small companies, startups, and some privately owned companies may yet value generalists and "personalities", but I believe most well run large publicly traded companies will be increasingly designed around modular, interchangeable, specialist units of labor. These labor units may be aggregated and outsourced, or replaced by similar units -- as the market requires.

Just as in nature, there are many paths to success. Standardized specialized labor units may be the dominant paradigm for very efficient 21st century corporations.

Medium lobster defends the President

Bush is not without intelligent allies:
More importantly, one must recognize that there are limits to what powers the federal government should exercise in a crisis. Yes, it is the right and duty of the president to override state drug policy, to determine who can or cannot marry, to indefinitely detain citizens without due process and to torture and kill prisoners as he sees fit, but disaster relief is a matter that should be left to the states.

Fafblog: With Great Power Comes Little Else
This blog is fair and balanced, and so is Fafblog.

Mars - the water planet

What do we need to get some public excitement going here?

Glaciers. Buried seas. Equatorial ice belts.

What are we waiting for -- Dejah Thoris sunbathing?

Come on. Darnit. Show some excitement. Organic dust in comets. Water on Mars.

I hope there's more imagination in China. Someone's got to go there ... (Since they may have to be elderly, maybe I'll get to make the trip someday ...)

Escape from voice mail hell - a database of tips on how to get a human being

A wondrous net resource, a database of techniques that will bypass voice mail systems and get to a human being. Another advance in the eternal war between vendors and customers.

Find-A-Human

Wednesday, September 07, 2005

Firefighters deployed to New Orleans -- to walk beside George Bush

I'd like to see some substantiation, but perhaps if enough blogs cite this the press will follow-up for us:
Brad DeLong's Semi-Daily Journal: The Best Use of Firefighters: Props in a Photo-Op

... As specific orders began arriving to the firefighters in Atlanta, a team of 50 Monday morning quickly was ushered onto a flight headed for Louisiana. The crew's first assignment: to stand beside President Bush as he tours devastated areas....
The allegation is that Bush is all hat and no horse.

Monday, September 05, 2005

Hairworm: another creepy mind controlling parasite

In this case the 'mind' is that of a grasshopper: Parasitic Hairworm Charms Grasshopper Into Taking It for a Swim - New York Times. The hairworm compels its host grasshopper into jumping in the water. Hopper drowns, long creepy worm exits.

I've blogged on a number of these stories -- biologists seem to find examples of parasite mind control or physiologic overrides everywhere they look. Makes me wonder again if we were different back when we had worms.

Which reminds me of Toxoplasmosis. I've been skeptical, but my skepticism is waning.

Which makes me think of HIV. Toxoplamosis is very common in HIV infected persons. Almost ubiquitious. If it does alter behavior, perhaps by making humans more careless and less inhibited, then toxoplama infection in HIV might have the side-effect of spreading HIV (and thus feathering its own bed). Creepy.

Update 9/27/05: On further consideration -- what about Syphilis? That treponeme has enough DNA and species adaptation that it would be a natural host controller. It would be logical for syphilis infection to increase promiscuous behavior ...

Molly Ivins has an article archive at working for change

I used to read Molly at the Fort Worth Star-Telegram, but they moved to registration only readership. I've just learned she can be read without registration here: Molly Ivins Archive.

I'll have to add her back to my news page.

FEMA Disabled: LA Times via DeLong

Brad DeLong's Semi-Daily Journal: Why FEMA Was Missing in Action

Old story. Slash budget, appoint flunky. The bureaucrats that actually do all the work, and know what to do, quite.
The agency's core budget, which includes disaster preparedness and mitigation, has been cut each year since it was absorbed by the Homeland Security Department in 2003. Depending on what the final numbers end up being for next fiscal year, the cuts will have been between about 2% and 18%. The agency's staff has been reduced by 500 positions to 4,735.
I know a few federal bureaucrats. Impressive people. Dedicated public servants. Scrupulously apolitical -- as they must be in public. They're the equal of the private sector executives I know. They can take other jobs. Under Bush they've been taking those other jobs.

New Orleans: The Problem of the Weak

Ayn Rand had a simple solution for the "weak" -- they died. She had more than a passing love for social darwinism.

This is not rare. It is deeply embedded in the modern Republican party: Gordon's Notes: What Is Conservatism and What Is Wrong with It?. A variant of this, that wealth is God's blessing upon his chosen, is at the core of theocratic capitalist fundamentalism.

New Orleans is the lesson for America on what this principle means in practice. The elderly, the young, the disabled, the poor -- the weak and those who love them -- they were stuck. The lack of systems to protect them, the slow response to their distress, is all consistent with Rand's Objectivism and Bush's odd blend of libertarianism and theocratic capitalism. I'm sure racism played some role, it's a part of every aspect of our life -- but I think that the deeper issue is a universal disdain for "the weak".

The catch is, if one accepts Ayn Rand's worldview, one must be comfortable with the suffering of "the weak". Those inclined this way will find many powerful allies. Perhaps they will adopt a badge so that all may know who they are.

Evacuate and abandon the children?

Well, they do allow children on New Orleans evacuation buses. Pets, however, are forbidden.

Reading the Washington Post this morning (no link, Blogger is barely functioning right now) at least a few families are resisting evacuation because it means abandoning their pets to certain death.

My doggie is gone, but were she were alive I would not leave her without a significant struggle (It's a bit more complex now since our kids need me alive too, but I'd try to save everyone.)

Is there some middle ground that could be taken for late evacuation? Some shading of the rules? Something like "come back when you're done with everyone else"?

Heck, most dogs are better bus companions than my kids.

Update 9/6/05: A Humane Society story tells us sometimes the rules do get bent ...

...Moret Williams and Sebastian left New Orleans together. Sebastian floated on an air mattress at his owner’s side as Moret Williams waded through polluted, neck-deep floodwater, pulling the mattress along with him. Man and beast managed to reach an elevated portion of Interstate 10, but the helicopters that were taking evacuees to buses weren’t allowing pets on board.

“There was no way I was leaving without him,” Moret Williams says, and so he did what so many have had to do in the past week: He improvised. He put Sebastian in a large black trash bag and begged him not to make noise.

Amazingly, the dog obeyed, though he did squirm at one point—a point that could have ruined the whole plan. “He bumped against the pilot,” Moret Williams says, a small smile creeping onto his face. “The pilot just goes, ‘I didn’t see nothing.’”

They need donations. I'll do one in honor of our old doggie.