Fake rabies vaccine

10,000 doses.

China Blacklists 400 Exporters - Forbes.com

... Earlier this week, the official People's Daily reported, police detained a further 17 members of a gang in Heilongjiang province producing counterfeit medicines. In an earlier raid on the gang, authorities seized 10,000 doses of bogus rabies vaccine, 20,250 bottles of a fake version of a medicine used to treat cardiovascular disease and 211 bottles of blood protein. In all, the paper said, police confiscated fake versions of 67 medicines produced by 53 companies...

Maybe I need to reconsider my principled opposition to Hell.

Solving the china import problem; $1 million prize for each recall

Want to solve the China problem?

Why lead-tainted Chinese goods slip through despite U.S. recalls -- chicagotribune.com

...Three decades after the federal government significantly toughened regulations on lead in children's products, American companies have yet to find a way to successfully screen the flood of imported products for the toxic metal.

The federal watchdog charged with ensuring they do so is overwhelmed and often ineffective. And the growing list of lead recalls of children's products underscores how the metal, slathered on with paint or mixed in with other raw materials, is more pervasive than many American consumers ever imagined...

It's not so hard.

Offer a $1 million prize to each person who detects a problem that triggers a product recall. I'll bet most of the prizes are won by Chinese entrepreneurs. Within 3 years the recalls would stop.

Next, I'll bring peace to the middle east.

The Center of it All

The center of it All.

2011 comes early: Ms. Carbon Tax, meet Mr. Bridge

I figured American life would change when gas hit $5/gallon in 2011. I picked that date because I figured we won't get a carbon tax through before 2013. That was before one of my local bridges took a tumble and I started to do the math on 77,000 "deficient" (rating =4) bridges and wonder how much it costs to (re)build a bridge. If we assume an average cost of, say, $30 million each, and we assume we replace/rebuild only 40,000 deficient bridges, that's $1.2 trillion dollars.

Now, perhaps we'll decide that the I-35W collapse was basically in line with expectations. We all understand that bridge ratings are probabilistic -- the yearly risk of catastrophic collapse is not 0% at the highest rating (10) or 100% at the lowest rating (0). Maybe it's something like a 1/100,000 risk at the rating of 4, with a substantially higher risk of non-catastrophic failure. With 77,000 bridges at that rating we should expect one to collapse every few years somewhere in the US and approximately 50 people to die or be injured by bridge collapse every 1-2 years.

That's a risk that a Vulcan would probably find quite reasonable. It's probably significantly less than the risk we assume with current food imports; riding a motorcycle is probably a hundred to a thousand times higher risk. Logically we may decide to just accept that and stick with our current bridge replacement/repair policies.

Humans are not logical. There's a good chance we'll run up a trillion dollar infrastructure repair bill rather than have yearly bridge collapse headlines.

We could simply borrow to build. It's a much better investment than the Iraq war, for example. I have a hunch though that Bush has busted our budget already. So we need to raise a trillion dollars.

We also need to reduce CO2 emissions.

We also need to decrease the load on our old infrastructure.

Gee, I wonder how we could do all of these things ...

$5/gallon by 2009?

PS. If I were in a business related to bridge construction, I'd be hiring today ...

Update 9/17/07: This is looking more likely ...

Update 9/21/07: It occurs to me that this is the cure for the AMT problem. More on that in a f/u post.

Bridges: 77,000 deficient, 750 have I-35W design

At Bridge Site, Search of River Moves Slowly - New York Times

... Dan Dorgan, a state bridge engineer for the Minnesota Department of Transportation, said a “deficient” designation did not mean a bridge needed to be immediately replaced; 77,000 bridges across the country, he said, have a similar designation...

Elsewhere I read that 750 bridges have the same design as our fallen I-35W bridge. I wonder what percentage of those are rated as deficient?

Maybe Google will start attaching design and deficiency rations to Google Earth/Maps. I bet that would be a good way to attract users.

This accident may end up costing billions ...

8/3/07 Update: I thought a bit more about how Google could accelerate the infrastructure review. A "route around risky bridge" option for Google Map directions would concentrate minds wonderfully. One can readily imagine icons for bridges with the I-35W design and risk designation. Did I say "billions"? Sorry, I meant tens to hundreds of billions ...

8/9/07 Update: My wife points out that as much as we may despise Pawlenty, it was the Ventura administration, albeit as part of a GOP initiative that returned a state budget surplus to the taxpayer rather than, say, use it to repair bridges. So Jesse Ventura deserves a chunk of the I-35W bridge for his desk.

Macworld - what the iPhone needs

I've seen a lot of lists of what the iPhone needs, but this MacWorld list most resembled my own: Macworld: First Look: iPhone fixes we want to see. I'd break the list into two parts: one part that's highly desirable and the other part that's so critical I can't buy the phone for fear Apple doesn't intend to address the problems. The latter list includes third party applications, tasks, work/home/family calendar management, search, cut and paste, etc. I could live with the crummy AT&T network and the lack of GPS if I had those features.

My experience with iPhoto and Aperture has taught me that Apple can take an incredibly long time to add features I consider critical, such as Library merge in iPhoto and date value edits in Aperture (neither exist). Given that experience, I can't buy the darned phone hoping Apple will fix the deal killers. I'm not Apple's target market, and won't necessarily listen to my concerns.

Wikipedia and the I-35W collapse

As expected, Wikipedia now has a good initial entry on the I-35W Mississippi River bridge collapse. This will be the place to go over the next few weeks and months to get an understanding of what happened. The Wikipedia article references the National Bridge Inventory but I was unable to find any record for the 35W bridge at this time. I will be most interested in seeing a list of bridges of similar age, design and history -- though one or more of construction error and local geology may turn out to be relatively unique contributors.

The Wikipedia article links to the Silver Bridge collapse of 1967, the outcome of the subsequent investigation suggests what may lie ahead:

... The collapse focused much needed attention on the condition of older bridges, leading to intensified inspection protocols and numerous eventual replacements. There were only three other bridges built to a similar design, one upstream at St Mary's and a longer bridge at Florianopolis, Brazil. They were both closed immediately, and the St Mary's bridge demolished in 1971....

I suspect we'll know within a few days which bridges in the US have a similar design.

Update 8/2/07: Culturally, slow to anger, but ....

Update 8/2/07: I've seen mentions of a bridge failure in 1983, the reference is to metal corrosion that caused the collapse of the Mianus River Bridge in Connecticut, killing 3 people and injuring 5 others. Wikipedia has a list of bridge disasters.

TSA Administrator on No-Fly list

I was wondering when Schneier would get to the "no-fly list" part of his interview with the TSA Administrator, Kip Hawley. It came out today.

My read is that Hawley was defensive and his answers this set of questions were weak. Here he discusses the new redress procedure ... (emphasis mine)

Schneier on Security: Conversation with Kip Hawley, TSA Administrator (Part 3)

...KH: ... if someone is either wrongly put on or kept on, the Terrorist Screening Center (TSC) removes him or her immediately. In fact, TSA worked with the TSC to review every name, and that review cut the no-fly list in half. Having said that, once someone is really on the no-fly list, I totally agree with what you said about appeal rights. This is true across the board, not just with no-flys. DHS has recently consolidated redress for all DHS activities into one process called DHS TRIP. If you are mistaken for a real no-fly, you can let TSA know and we provide your information to the airlines, who right now are responsible for identifying no-flys trying to fly. Each airline uses its own system, so some can get you cleared to use kiosks, while others still require a visit to the ticket agent. When Secure Flight is operating, we'll take that in-house at TSA and the problem should go away.

So the list was so bad an initial review dropped it by 50%. I hope Hawley is simply dissembling and that he's not so foolish as to think his answers are reasonable. Note the problem with each airline having their own procedures for dealing with "cleared" names. What a mess.

A local bridge falls

A local bridge fell into the Mississippi today. We're on the front page on the BBC World:

BBC NEWS | Americas | Six dead as US bridge collapses

...Russ Knocke, a spokesman for the Department of Homeland Security, told the AFP news agency: 'There are no indications of a nexus to terrorism at this time.'

The initial reports said "not a terrorist event", but of course that's unknowable. Later reports used "No indications", which is at least plausible.

We're a pretty wealthy state without any recent history of major infrastructure problems, and there's been no significant work on that bridge recently. Bridge engineering is supposed to be very well understood. So either our engineering textbooks need a rewrite, or there was something wrong about the initial construction or later repair of this particular bridge (and its peers?), or somebody blew it up. The last seems very unlikely but the other explanations aren't too likely either.

Journalism in transition and not-so-irrational voters: Rosenberg

Scott Ronsenberg, who's just left Salon, wrote two posts that merit a broader attention. The first is simply a response to Kristoff's recent "irrational voter" essay. Rosenberg expresses exactly what I thought as I read Kristoff's article. I think the American voter is future shocked, comatose, AWOL and derelict, but I thought Kristoff's examples of irrationality were .. umm ... irrational. Rosenberg captured my thoughts perfectly:

Those darn irrational voters.

... What are the ways in which voters are “worse than ignorant”? Kristof summarizes Caplan’s complaints of “systematic error” in voter rationality: Voters share “a suspicion of market outcomes and a desire to control markets.” They have “an anti-foreign bias,” evidenced by an unwillingness to embrace free trade wholeheartedly. They share “a neo-Luddite bias against productivity gains that come from downsizing or “creative destruction.’” And they have a “pessimistic bias, a tendency to exaggerate economic problems.”

Gee, it sounds like the real problem Caplan has with the voting public is that they don’t agree with the program of conservative economists!...

...Personally, I’m reasonably comfortable with the pro-free-trade argument. But you won’t find me sneering at those who sense that the dynamic of the global economy is not doing them or their families any good.

More significant in the longer run is Rosenberg's summary of the state of the journalist in the Murdoch-WSJ era:

Scott Rosenberg’s Wordyard » Blog Archive » Murdoch, the Journal, and the newsroom diaspora

It is no surprise that Rupert Murdoch will be the new owner of Dow Jones and the Wall Street Journal...

...The truth is that most professional journalists in the U.S. have lived in a cocoon for decades...

... I don’t trust Rupert Murdoch. He has a long and well-documented record of using his properties to further his own agenda. But I trust that there are a lot of smart writers and editors at the Journal. Either they’ll get an opportunity to reshape their paper in a way that suits the times and their own consciences — or they’ll find themselves in the great newsroom diaspora with the rest of us, helping us figure out new models for the future.

WSJ journalists have no excuse for complaining about the cold winds of capitalism, I'm sure they're too smart to expect much sympathy. I do hope that the best of them take Rosenberg's challenge and join a new world, but I also remember that when BYTE died, nothing replaced its value. (The sum of the entire tech blogsphere is probably the closest thing we have now, and that took about ten years post-BYTE to emerge.)

PS. As to the fate of the WSJ, as I've written before, I'm an optimist. At worst it will stay about the same. At best Murdoch will eliminate the editorial staff and keep the news people. Next best is to keep the editorial staff but so weaken the news function that it dies a slow death. All improvements.

The way we think: reason as an afterthought

Towards the end of an article reporting how much unnoted context alters our feelings and behaviors, a NYT article describes the implication for how we think. It's another in a long series of blows to the idea that we're fundamentally rational (emphases mine)...

The Subconcious Brain - Who's Minding the Mind? - New York Times

... an area called the ventral pallidum was particularly active whenever the participants responded.

“This area is located in what used to be called the reptilian brain, well below the conscious areas of the brain,” said the study’s senior author, Chris Frith, a professor in neuropsychology at University College London who wrote the book “Making Up The Mind: How the Brain Creates our Mental World.”

The results suggest a “bottom-up” decision-making process, in which the ventral pallidum is part of a circuit that first weighs the reward and decides, then interacts with the higher-level, conscious regions later, if at all, Dr. Frith said.

Scientists have spent years trying to pinpoint the exact neural regions that support conscious awareness, so far in vain. But there’s little doubt it involves the prefrontal cortex, the thin outer layer of brain tissue behind the forehead, and experiments like this one show that it can be one of the last neural areas to know when a decision is made.

This bottom-up order makes sense from an evolutionary perspective. The subcortical areas of the brain evolved first and would have had to help individuals fight, flee and scavenge well before conscious, distinctly human layers were added later in evolutionary history. In this sense, Dr. Bargh argues, unconscious goals can be seen as open-ended, adaptive agents acting on behalf of the broad, genetically encoded aims — automatic survival systems.

In several studies, researchers have also shown that, once covertly activated, an unconscious goal persists with the same determination that is evident in our conscious pursuits. Study participants primed to be cooperative are assiduous in their teamwork, for instance, helping others and sharing resources in games that last 20 minutes or longer. Ditto for those set up to be aggressive.

This may help explain how someone can show up at a party in good spirits and then for some unknown reason — the host’s loafers? the family portrait on the wall? some political comment? — turn a little sour, without realizing the change until later, when a friend remarks on it. “I was rude? Really? When?”

Mark Schaller, a psychologist at the University of British Columbia, in Vancouver, has done research showing that when self-protective instincts are primed — simply by turning down the lights in a room, for instance — white people who are normally tolerant become unconsciously more likely to detect hostility in the faces of black men with neutral expressions.

“Sometimes nonconscious effects can be bigger in sheer magnitude than conscious ones,” Dr. Schaller said, “because we can’t moderate stuff we don’t have conscious access to, and the goal stays active.”

..Using subtle cues for self-improvement is something like trying to tickle yourself, Dr. Bargh said: priming doesn’t work if you’re aware of it. Manipulating others, while possible, is dicey. “We know that as soon as people feel they’re being manipulated, they do the opposite; it backfires,” he said...

Really, it's amazing we do as well as we do. Our mind seems a pretty thin veneer on a heck of a lot of evolutionary programming. I am reasonably certain, however, that self-awareness varies from person to person. In other words, consciousness, like strength, speed, and wit, is a variable. Perhaps with some training we can begin to acquire second hand access to our unconscious controllers, and subvert them. So, perhaps we cannot directly detect an unconscious motivator, but perhaps we can become better at evaluating our own behaviors. When we find ourselves skeptical, or friendly, or generous, or competitive, we might then infer the presence of an unrecognized trigger, and thus infer our unconscious goals.

More in another blog on the implications for the management of persons with behavioral problems ...

Recommender systems - so that's why they've been disappointing

Recommender systems for music and books haven't lived up to initial expectations. Netflix and Amazon give me pretty decent recommendations, but among other things they get confused between things I buy for myself and things I buy for other people DeLong excerpts Slee to suggest a host of other problems -- mostly fraud related.

There's so much money riding on recommender systems even clumsy fraud is common, so it's rather likely that subtle fraud is also common. It's the same problem Google has had, since Google's original search approach was a form of recommender system.

Useful recommender systems may first require a good reputation and identity management infrastructure, or be based on data points that cost money to create. Not coincidentally, when I'm researching Amazon the first thing I look at is the sales ranks for the product domain I'm interested in. Then, for each product that's selling well, I look at the negative reviews first. I don't pay that much attention to the star rankings or the positive reviews.

A mouse model for calcineurin-type Schizophrenia: exciting news indeed

This is terribly interesting news on several fronts. Mouse models of a variant of autism emerged about 1-2 years ago, and they've radically accelerated our understanding of that mind/brain disorder. We can reasonably expect a similar revolution from this discovery ...

MIT research may lead to better schizophrenia drugs - MIT News Office

CAMBRIDGE, Mass.--MIT researchers have created a schizophrenic mouse that pinpoints a gene variation predisposing people to schizophrenia...

..Nobel laureate Susumu Tonegawa, director of the Picower Center for Learning and Memory at MIT and a Howard Hughes Medical Institute investigator, found that genetically engineered mice lacking the brain protein calcineurin exhibit a number of behavioral abnormalities shared by schizophrenic patients.

In a related study with researchers at Rockefeller University in New York, MIT scientists show that variation in a human calcineurin gene also is associated with schizophrenia. Calcineurin--part of a biochemical pathway in the brain linked to receptors for two brain chemicals, NMDA and dopamine--plays a significant role in the central nervous system.

This is the first study that uses animals who demonstrate an array of symptoms observed in schizophrenic patients to identify specific genes that predispose people to the disease...

... Tonegawa creates tools to explore the genetic underpinnings of the molecular mechanism for memory. Genetically engineered mice who are missing the brain enzyme calcineurin were previously shown to have an impairment in short-term, day-to-day memory formation, known as working memory. This kind of memory also is impaired in schizophrenia patients.

Further testing of these mice by Picower Center research scientist Tsuyoshi Miyakawa revealed that they also have attention deficits, aberrant social behavior and several other abnormalities characteristic of schizophrenia.

Picower Center research scientist David Gerber then collaborated with Rockefeller's Maria Karayiorgou to examine calcineurin genes in DNA samples from schizophrenic patients and their immediate relatives. The researchers found an association between a particular calcineurin gene and schizophrenia.

"This is an intriguing series of findings," Tonegawa said. "The combination of evidence from the genetically altered mice, together with the human gene studies, create a strong argument to link calcineurin with schizophrenia."...

... Alterations in multiple genes are believed to predispose people to schizophrenia. Tonegawa suspects that many of these genes may turn out to be components of the calcineurin pathway or to directly interact with the calcineurin pathway.

"Once we better understand exactly which genes are involved, we will know how proteins are affected, and we can set up a test to screen large numbers of compounds to identify ones that have desired effects on the activity of these proteins," Tonegawa said. "This can potentially lead to the discovery of new kinds of drugs for psychiatric conditions such as schizophrenia."

In addition to Gerber, Miyakawa, Karayiorgou and Tonegawa, co-authors include Joseph A. Gogos of Columbia University, and Diana Hall and Sandra Demars of Rockefeller University. Authors on the mouse study include research specialist Lorene M. Leiter and Hongkui Zeng of MIT, and Raul R. Gainetdinov, Tatyana D. Sotnikova and Marc G. Caron of Duke University...

If this actually works out, Tonegawa will earn another Nobel.

Age of Parody: Steven Colbert* and the Fake Steve Jobs

We've all read that the young-uns get all their news from watching Steven Colbert, a "fake" newscaster. We also know that Colbert has the highest quality news coverage anywhere, so the young-uns aren't so dim after all.

Which brings one to the media analysis of FSJ -- aka Fake Steve Jobs. One reason this geek parody site is widely read by Mac fans is that the commentary is often quite insightful, and, of course, it's well written, reasonably funny, and generally entertaining.

I think the Soviet Union was famous for high quality parody. I hope our age of Parody has no common roots.

*PS. Since I'm kind of removed from popular culture, I first typed "Stephen Coulter". Doesn't work. In the old days I've have been stuck. Now I googled on "you tube" "steven" and "parody". First hit.

Variations on the publicly traded company: two class ownership

James Fallows tells us what the New York Times and Google have in common: two tier corporate ownership (class A and B shares). I've passed through several variations of the modern corporation, and like most veterans I know the limits of both the private and public company. Private companies are capital limited and, eventually, channel limited. Public companies survive by brute force, but have all the grace and maneuverability of a steamroller.

Lately we've seen "private equity" variations, which seem to be largely a variation on the leveraged buyouts of the 80s. I hadn't recognized, however, that Google had implemented a private/public model previously known primarily in the news industry.

Fascinating.

I love blogs.