Friday, October 30, 2009

On vaccines

Via Daring Fireball, a superb essay on vaccines.

And that was "just" chickenpox.

Moderns have no idea of what diphtheria was like. Or, for that matter, tetanus. (I once knew a patient who'd survived "lockjaw" though -- it still happens rarely).

Update 10/31/09: Charlie Stross reminded me of a great post I read some time ago.

Thursday, October 29, 2009

Midwest Skijorers Club

Fourteen years ago I authored one of the very first skijoring pages on the WWW.

Heck, it might have been the first in English. We didn't have Google back then, so it's hard to say.

My own wee bit of history.

Which is all by way of introducing another mark of the Twin Cities' greatness - the Midwest Skijorers Club.

Yes, we have our very own local skijoring club. As if our superb bicycle trails weren't evidence enough of our unequalled greatness.

Now if only it would stop $!$!%$ raining ...

Windows 7 pounds OS X: the screen scales

OS X was supposed to have had resolution independence 3 years ago. Apple failed.

I've been told by a real world user that Windows 7 resolution adjustment works pretty well. Apple's 27" iMac may look, to middle-aged eyes [1], quite a bit better running Windows 7 than running OS X 10.6.

Resolution independence. Vastly better remote control functionality. In what other domains does Windows 7 pound OS X?

[1] Note Google now scales their search screen for presbyopic eyes. On another front, in winter aging fingers don't work all that well on the iPhone touch screen either. Too dry. Jobs wears reading glasses and I bet his fingers aren't much better than mine. Denial?

The economics of modern military action

In the modern world, large scale human military operations are quite expensive (emphases mine) ...
Kristof - More Schools, Not Troops - NYTimes.com
... For the cost of a single additional soldier stationed in Afghanistan for one year, we could build roughly 20 schools there ...
The 1 soldier/20 school ratio is a reflection of both the cost of the soldier and the low cost of Afghan construction. It does not include the cost of operating the schools but the point is well made. Our army of one is very expensive.

This is curious because other military actions are getting cheaper. The cost of destruction (aka "cost of havoc") has fallen dramatically over the past few centuries. Even very poor people can afford very effective weaponry, command and communications infrastructure, spy satellites, and even weapons of mass destruction (an interesting variant is the low cost of climate engineering blackmail).

The low cost of certain kinds of military action may dramatically increase the cost of occupation-class operations, particularly those where soldiers can make choices. Separately, soldiering is increasingly a high skills occupation -- and one that's very hard to outsource to a low wage nation. Non-outsourcable high skills occupations are increasingly costly.

Perhaps one of the lessons of Iraq and Afghanistan will be that no future nation will be able to afford the cost of occupation.

Interesting.

Wednesday, October 28, 2009

Will football go the way of boxing?

Football is insanely popular. It's America's top sport.

But boxing was popular once too. It peaked in the middle of the 20th century, but now it's insignificant. Even back then it was hard to ignore what happened to boxers. Mohammed Ali was the last straw.

Within twenty years, if the game doesn't change, football (that is, American football -- not "soccer") will go too ...
10 amazing truths you already suspected / Go ahead, pretend you didn't know. Pretend it wasn't obvious. (Volume II!)
... Witness Malcolm Gladwell's half-stunning, half-obvious piece in a recent New Yorker, summed up thusly: nearly every football player in America, from high school on up through the NFL -- especially there -- will suffer some level of brain damage and head trauma, from moderate to severe to early-onset dementia, even after just a year or two of play, even if he never turns pro at all...
Parents will start to discourage kids from playing high school football, and those with money will withdraw financial support for the high school game. Colleges will be successfully sued -- after all, they can hardly claim to be uninformed and they have a special responsibility to their students.

The game will have to be radically revised to lower the amount of head trauma involved.

Google’s consumption of the mapping industry

Wilson Rothman (Gizmodo) has a great essay on Google’s consumption of TomTom, Garmin, and the map data industry. It isn’t just the new Droid-only Google Maps Navigation (Apple’s App Store non-rejection is pending). It’s also that Google has built their own US (and Canada?) map database. Google no longer needs the data they were buying from “Tele Atlas” and “Navteq”.

Presumably Apple or someone else will buy up the remnants of the mapping industry.

Google is a disruptive company. Per Rothman …

… This is not an attack of Google's business practices, but an explanation of the sort of destructive innovation that has made them so huge so fast … Though predecessors like Microsoft experienced similar explosive growth, and grew a similar sudden global dependence, we've never seen the likes of Google. The GPS business isn't the only one that will be consumed by its mighty maw before it's had its run…

Rothman is a bit too confident about Google’s ability to take down Office (Google Apps aren’t that good), but he’s right about things like Google Voice.

Next up? Chrome OS beta is out already. I expect to see the Google branded netbook within the next few months. We’ll see if they hit my $150 predictive WiFi price point (free with a Verizon/Google 2 year bandwidth-adjusted data contract).

Tuesday, October 27, 2009

Fermi Paradox: life is extremely rare

My preferred Fermi Paradox solution is that technological societies have only a short-lived interest in roaming the physical universe. A more common explanation, now that rocky planets seem ordinary, is that life is extremely rare. I liked the way this physics professor came to that conclusion ...
Information Processing: Evolution, Design and the Fermi Paradox - Stephen Hsu

... What is the time scale for evolution of complex organisms such as ourselves? On Earth complex life evolved in about 5 billion years (5 Gyr), but one can make an argument that we were probably lucky and that the typical time scale T under similar circumstances is much longer.

There is an interesting coincidence at work: 5 Gyr is remarkably close to the 10 Gyr lifetime of main sequence stars (and to the 14 Gyr age of the universe). This is unexpected, as evolution proceeds by molecular processes and natural selection among complex organisms, whereas stellar lifetimes are determined by nuclear physics.

If T were much smaller than 5 Gyr then it would be improbable for evolution to have been so slow on Earth...
Basic Bayesian reasoning, and a new perspective for me. Good one Dr. Hsu!

Update 10/29/09: Some nice comments, but, above all, Charlie Stross drops the hammer. It's an intellectual tour de force from someone who gets paid to think about these sorts of questions. Charlie flips the question around, and shows that waiting-time-for-stuff-like-us is actually very short. He doesn't fess up to his answer to the Fermi Paradox though.

Update 10/29/09b: Through some back and forth in Charlie's comments section, I end up searching on his treatment of the FP in Accelerando -- and one of the top hits is my 2006 Amazon review of his book. He's very much in the church of "post-singular societies don't go a wandering" (me too), but he explains why. According to Charlie Stross, life without bandwidth is intolerable ...

Progress is not guaranteed

With the past week I needed to put a personal web page and I had to work with a problem best managed by a cross between an Outline and a database.

For the first task I wanted the equivalent of Front Page, a powerful document centric wysiwyg authoring tool from the previous century. For the second task I needed GrandView, a DOS app from the 1980s (if I had a Mac at work I'd use today's OmniOutliner Pro).

It's not just old software tools that vanish; current tools are losing advanced functionality. iTunes Smart Playlists are withering and the smartest parts of OS X are falling away.

On the bright side, I'm not getting any smarter either. So maybe software is simply getting ready for my future self.

--
My Google Reader Shared items (feed)

That which does not kill me postpones the inevitable.

Despair, Inc: Adversity: "That which does not kill me postpones the inevitable."

Love 'em.

I'm with the ancient Greeks. Embrace tragedy.

Sunday, October 25, 2009

Apple does things differently

I've read this before. Apple has very small, very productive, engineering teams ...
/dev/why!?!: The loss of ZFS

...I recall having a discussion with the head of a university FS team who was discussing the FS he was working on. He was pitching it to a group of Apple engineers. It was some interesting work, but there were some unsolved problems. When he was asked about them he commented that they didn't have enough people to deal with them, but he had some ideas and it shouldn't be an issue for a company with a real FS team. It turned out his research team had about the same number of people working on their FS as Apple had working on HFS, HFS+, UFS, NFS, WebDAV, FAT, and NTFS combined. I think people don't appreciate how productive Apple is on a per-engineer basis. The downside of that is that sometimes it is hard to find the resources to do something large and time consuming, particularly when it is not something that most users will notice in a direct sense...
--
My Google Reader Shared items (feed)

AT&T surprise charges with added lines and phone switch

When we first switched from Sprint to AT&T I catalogued all the extra fees and surprises. Recently I switched Emily from a BlackBerry Pearl to an iPhone 3GS (very successful move) and added one child to our family plan ($10/month – in theory).

These were the surprise charges this time around:

  • $18: “one time charge for upgrade fee” for Emily’s BB to iPhone switch
  • $26: “activation fee” for my son’s added line

By AT&T standards these are minor hits. They annoy me, but I’m more annoyed that I have to pay for SMS and MMS messages I can’t block. (I’ve written my representative about those, every time I get these charges I send off another email to a federal legislator.)

We get a “national account discount” (many large companies negotiate these plans). I confirmed Emily is still receiving it after the switch, but I didn’t see it on my son’s plan. So I’ll follow-up on that with the AT&T corporate service number.

I also need to inquire if the “national account discount” should have covered the “upgrade fee” and “activation fee”.

Incidentally, when I reviewed our online account settings I discovered new options to opt out of AT&T’s despicable SMS spam.

See also:

Saturday, October 24, 2009

H1N1 - things new to me

I have an average physicians knowledge of H1N1, so most of what I read is uninteresting. This MinnPost article by a local physician, however, had some real gems. Osterholm is a national expert on pandemics living in MN. His predictive record is imperfect, but he has some interesting observations (emphases mine) ...
MinnPost - Tapping Minnesota’s top H1N1 expert: Michael Osterholm

... Osterholm chairs a National Institutes of Health (NIH)-sponsored panel that tracks emerging influenza infections. This year's meeting included a group of virologists and influenza experts that Osterholm considers to be the best in the world. "And every one of them said without a question that if this H1N1 acquires a certain PB2 gene, we're in big trouble," Osterholm recalled. "Well, it did it [acquire the PB2 gene] in the Friesian islands off of the Netherlands this August, and we didn't see that. Everyone was holding their breath, but at least, so far, nothing has happened with that. And so we don't understand in many instances what components of the mutt are really critical, which ones are important and which ones don't make any difference."

... I have been concerned from the beginning about over-promising and under-delivering on this issue. Just knowing this vaccine and what it takes, when they put the 140 million-dose estimate out that would be here in mid-October, I just knew that that was going to be a great overreach....

... I find it remarkable that we have as much as we do as early as we do, given the timeline..."

Long before the arrival of the novel H1N1 virus, Osterholm and other infectious disease specialists were lamenting our country's antiquated vaccine production system, which he points out relies on 1950s technology that's slow and unreliable. And even the way in which influenza vaccines work is a little bit murky.

"On Monday, I'm giving the keynote address to the NIH vaccine research meeting," he said. "I'm actually using H1N1 to highlight the many problems we have today with the vaccine industry. It's a simple as, 'You know, we don't have a clue what protects you in a flu vaccine.' So we measure hemagglutinin [the 'H' in H1N1] using outdated measures for antigen [a molecule on the surface of a virus that our immune system uses to key in on it], but we don't really know."

"When the CDC did their sero-survey looking for hemagglutinin antibody to novel H1N1 in the elderly, they found about 30 percent of them having pretty good titers to the H1 N1 virus," Osterholm recalled. "But the bottom line is, the protection we're seeing in the 65 and older age population far exceeds 30 percent, and the point of it is that there is probably a huge part of cellular immunity that's tied to protection with the flu vaccine, and that's something we don't even understand....
... The one thing I do feel pretty good about is the safety issue. It's not because we know it from this vaccine, but from the time-tested seasonal flu vaccines we've used over the last 30 years."

So the vaccine will get here when it gets here, but do you have a sense of when the peak of infections will be?

"You know, I don't. As I said at the flu summit six weeks ago, I thought that by mid-October we'd be seeing what I call 'peak activity,' which is what we're seeing right now. That's how I thought it would build. What I don't know is how long this is going to last. Is it basically going to go into retreat for a while and then come back again in, say, December or January? We're burning through a lot of central people right now, meaning the rate of new infections is growing at such a rate that I think that we're not going to have that many [unexposed] people left in November, December or January to get a second wave...

Friday, October 23, 2009

The iMac 27: missing resolution independent OS X

Resolution independence means pixel counts wouldn't matter; very high pixel density screens needn't create itty-bitty text problems.

Once upon a time OS X 10.4 was going to have a scalable UI like this. Didn't happen. Then it was to be 10.5.

Now nobody mentions it.

On the other shore Microsoft has had some RI since Windows 95, but it's never worked quite well enough to be truly useful. Windows 7 takes RI further, but it's still not quite ready to go all the way.

It looks like the iMac 27 inch may remind aging Americans why RI is important ...
Apple iMac Review: 27 Inches and Less Chin - Apple imac 27 inch - Gizmodo

... at this pixel density, which is sharper than my notebook, it's almost too sharp, requiring me to sit closer than I would ordinarily do with a 27 inch display. I like the feeling of crispness — 16% crisper than the last generation. But my eyes feel like the pictures are being delivered by a land shark holding a laser pointer straight into my corneas, and I can feel the strain within minutes. I would have to jack up as many font sizes as possible or sit as close as I do to my MacBook to make it work for long long periods of time.
I'm as presbyopic as the next GOMER, so this matters. I'm going to have to work with this screen in the store for a while before I decide it's manageable at home. Lack of RI might save me a few hundred bucks.

The African mobile phone revolution continues

A few millennia ago I read quite a bit about "appropriate technology" applications for what was then known as "the third world" or "less developed nations".

In those days the idea was to find or invent product designs that returned value, but that weren't dependent on a lot of supporting infrastructure. Sometimes this might be a type of plow, or a type of solar oven. In the past decade or so there was a wind-up radio, More recently, there was the well intended originally MIT based OLPC laptop project

I think some of these ideas worked out, but others, like the OLPC, have been at best indirectly influential. Today's world is, despite our recent economic maelstrom, far more prosperous than the world of my childhood. These days "appropriate technology" may emerge to meet the needs of rural China or from African manufacturing, but it can also emerge in somewhat surprising ways (emphases mine) ...
Africa calling: mobile phone usage sees record rise after huge investment The Guardian

Africans are buying mobile phones at a world record rate, with take-up soaring by 550% in five years, research shows.

"The mobile phone revolution continues," says a UN report charting the phenomenon that has transformed commerce, healthcare and social lives across the planet. Mobile subscriptions in Africa rose from 54m to almost 350m between 2003 and 2008, the quickest growth in the world. The global total reached 4bn at the end of last year and, although growth was down on the previous year, it remained close to 20%.

On average there are now 60 mobile subscriptions for every 100 people in the world. In developing countries, the figure stands at 48 – more than eight times the level of penetration in 2000.

In Africa, average penetration stands at more than a third of the population, and in north Africa it is almost two-thirds. Gabon, the Seychelles and South Africa now boast almost 100% penetration...

Uganda, the first African country to have more mobiles than fixed telephones, is cited as an example of cultural and economic transformation. Penetration has risen from 0.2% in 1995 to 23% in 2008, with operators making huge investments in infrastructure, particularly in rural areas. Given their low incomes, only about a quarter of Ugandans have a mobile subscription, but street vendors offer mobile access on a per-call basis. They also invite those without access to electricity to charge their phones using car batteries.

Popular mobile services include money transfers, allowing people without bank accounts to send money by text message. Many farmers use mobiles to trade and check market prices.

... The share of the population covered by a mobile signal stood at 76% in developing countries in 2006, including 61% in rural areas. In sub-Saharan Africa, closer to half the population was covered, including 42% in rural areas...
This isn't new, the Economist and others have been covering mobile phone use in Africa for since the 1990s. It's a noteworthy and encouraging sign. It's "appropriate technology" that emerged somewhat unexpectedly, but has since received extensive support from governments and aid agencies, including Kenya's investment in new fiber optic connections.

Today these are fairly minimal phones, but Google has done some pretty ingenious things to provide voice and texting interfaces to Google services. In 3-4 years, today's simple phone users may have Android phones comparable to the iPhone of 2008.

We're gradually moving towards the Teledesic/One Laptop per Child vision, but along a less expected path.

Great news for humanity.

See also:

Thursday, October 22, 2009

Use Get Satisfaction to talk to Google

Today's announcement of Google's mind reading technology (for example) tells us where the Google Reader team looks for feedback (emphases mine):
... we'd love to hear your feedback — share your thoughts on our help group, Twitter or the Reader section of Get Satisfaction, a third party support community.
Somehow I don't think my tweeting about a really obnoxious Reader bug is going to make much of an impression. On the other hand, the Get Satisfaction site is kind of neat. It's a startup that allows businesses to outsource their customer community.

It's free for customers of course, and, like all new startups, you can authenticate with Facebook, your Google ID or OpenID (without sharing your password of course).

Looks like Google is a paying customer -- they currently have 42 products on GetSatisfaction.


Google's Help Forums have always felt like a waste of time - both when they were on Google Groups and in their current incarnation. I'll give Get Satisfaction a try.

Update 10/23/09: It worked. Get Satisfaction is where Google lives now. Forget the official help forums.