Arthritis - the feeds and queries (reference post)

I feel like I’m tied to a railroad track, and see the light of the train approaching. And I don’t know if it’s one mile away, or 500. 
Anonymous, a patient three years into leukemia remission.

Cancer will give many of us that oncoming train feeling, but of course the light is always there. We’re just good at denial. When we’re young and healthy the train is probably far away. When we’re 93 it’s pretty close. In between we try not to look.

There’s only one “train”, but there are lots of smaller hits along the way. Bicycles and cars maybe. One of them ran into me recently, so I’ve renewed an old interest in the so-called “rheumatic disorders” (misleadingly named after bodily fluid flow).

It really is an old interest. Before I figured out how to do medical school [1], I closely read the 1982 version of the Arthritis Foundation’s “Primer on the Rheumatic Diseases”. Within the broad bounds of unreliable memory I recall that osteoarthritis was a “wear and tear” disorder of aging, rheumatoid arthritis and a handful of other disorders were “auto-immune” diseases, gout and non-gout crystal deposition were relatively well understood, and many viral and non-viral diseases (Gonorrhea and, a bit later, Lyme) caused arthritis. Steroids (not the androgen variety!) worked very well on the auto-immune disorders, but the long term side-effects were horrible and inevitable. We had reasonable drugs for Gout, gold for Rheumatoid arthritis (some value [7]), and nothing for osteoarthritis. Okay, so we had NSAIDs like ibuprofen, but we already suspected they were a mixed blessing. We’ve kind of given up on them.

Things aren’t that much different 33 years later. Relatively recently we’ve realized that “osteoarthritis” covers a multitude of evils, some or all of which, like “psoriatic” arthritis, are more than “wear and tear”. We still don’t have any great treatments for Systemic Lupus Erythematosis, though we now do less harm with the treatments we have. Rheumatoid arthritis has seen the most care improvements, but, amazingly, we can’t actually cure it or any other auto-immune arthritis [3]. We still wonder about the role of infectious agents in creating or sustaining auto-immune disorders but we have few leads [2][6]. The most recent (2005) edition of the Primer on Rheumatic disease says of Osteoarthritis “It is clear that this … includes a variety of different conditions, but we have made less progress …”.

More recent publications have even undone old certainties; we’re no longer confident that the various flavors of psoriatic and osteoarthritis are primarily “arthritic” (greek: Arthron, joint). Disorders along the osteoarthritis - psoriatic arthritis spectrum may begin as diseases of the tendons. Some of them may be lifelong disorders of tissue healing; small injuries accumulate due to a healing defect, perhaps with later onset of an auto-immune component reacting to disordered tissues.

My medical school interest became personal as I watched my mother go through the arthritis experience for about 35 years, ending as “rheumatoid arthritis” (our classifications are imprecise). It wasn’t pretty.

Which is all by way of introducing this “reference post”; a blog post that I’m going to be revising and extending. It’s a post supporting my surveillance of our historically limited knowledge base. I’ll revise it periodically over the next year or two. Sometimes I’ll post/tweet about updates to this reference post, but most of the interesting results will appear in a pinboard RSS stream tagged “arthritis” [4].  

My surveillance relies on PubMed [5] (National Library of Medicine) RSS feeds. Anyone can create these, but I’ve never seen anyone but me write about them. I’ll list them by topic below, but first I’ll describe what I’m not monitoring.

I’m not monitoring care guidelines or the cutting edge of rheumatologic practice. I see a rheumatologist for that; that’s his job. If I want an update on current practices I’ll take a look at FP Notebook’s Rheumatology Book. I’m not interested in alternative or complementary therapies — that way lies madness. I’m only mildly curious about lifestyle factors; mostly because we know so little and very little research is going to get funded.

I am curious about tolerance induction — the Holy Grail of the rheumatic disorder treatment. We’ve been hammering on this decades, but we have new tools now. This is what we really want - a cure for at least some of these diseases. I’m looking for articles on disordered healing and secondary arthritic conditions, but I’ve yet to figure out a good search for that one. Likewise I’m looking for articles that relate loss of self-tolerance to a dysfunctional pseudo-neoplastic component of the immune system (yeah, this is definitely fuzzy). More concretely anything about the role of infections organisms in precipitating or maintaining arthritis.

Here are the RSS feeds and “similar articles” queries I’m revising and using for each of these topics. I wish there were RSS feeds for the “similar to” queries, as I learn the topics i’ll put create RSS feeds with similar results.

tolerance induction

• tolerance induction in arthritis (feed)
• peptide based immunotherapy (not limited arthritis, feed)
• T cell immunoglobulin-3 (Tim-3) therapy (query)
• tolerogenic dendritic cells

tendon injury (enthesitis) and arthritis

• enthesitis in psoriatic arthritis (query)

microbiome and role of infection in creating and maintaining arthritis

• microbial dysbiosis in rheumatoid arthritis (query)

Immune system and neural networks (because I figure the immune system is a form of neural network)

• Google scholar related article query

other

• psoriatic arthritis - natural history (not a query because this seems to be only article!)
• cimetidine and innate immunity (feed - because of this post)

- fn -  

[1] The way to do the didactic portion medical school is to maintain a relentless focus on examinations. If you’re doing well you may then indulge your passion and curiosity. 
[2] As a still distractible student I read the first speculative article written on an association between bugs living in the high acid stomach and gastric ulcer disease. Before then we thought the stomach was sterile; nothing could live in such a disagreeable environment. That probably contributed to my extremophiles and auto-immune disease post.
[3] Juvenile Rheumatoid Arthritis does resolve about half the time. Which is curious.
[4] Like all things Pinboard it has an RSS Feed: http://feeds.pinboard.in/rss/secret:c6ea18730310000211dc/u:jgordon/t:arthritis/. Sadly there are no RSS feeds for “similar article” queries and “My NCBI” doesn’t show feeds.
[5] My medical informatics career began in Family Medicine residence as a beta tester of the “Grateful Med” software. I believe the product manager, Rose Marie Woodsmall, was a dead head. I was among the last generation of medical students to use the paper Index Medicus to do journal research.
[6] I’d wondered years ago why we weren’t mining synovial fluid for foreign DNA. Turns out this was done in 2001 with interesting results, but the follow-up was limited until “microbiome” became a funding source.
[7] Gold was used to treat Rheumatoid arthritis from at least 1945 through the early 1990s. I seem to remember it was sometimes associated with extended remissions. I can find almost nothing on it written after 1965 or so, and nothing at all on how it worked. There’s very little on long term outcomes. Which is, you know, profoundly weird.

Update 12/18/2015

I have a hunch that whatever is afflicting me now is the end-stage of a congenital defect with soft tissue/tendon formation. I’ve always been prone to calcium deposits along tendons and to overuse tendonopathies. It would not be surprising that as I’ve aged my body’s ability to manage this problem, and heal from injury, has declined. That in turn could lead to some secondary auto-immune issues (prolonged inflammatory/antigen spill issues). I haven’t come up with a search criteria yet to explore this idea; it would probably show up in whole genome analyses. I would need to look for discovery of a gene associated with auto-immune arthritis/osteoarthritis that was important for tendon formation.

Extremophiles and auto-immune disease

The extremophiles are at home in near boiling water and the deep crust of the earth. Every ecological niche is colonized by life; and life forms everywhere work to change their ecology to suit themselves.

It is the inevitable logic of natural selection in action.

So then, why should the hot tissues of auto-immune disease be any different? How could there not be life forms evolved to that extreme environment? Life forms that might facilitate it, to defeat their enemies and extend their preferred environment. An ecology that, once created, will host competitors, some liking it hotter, some coder. An ecology with successor species, like any forest.

It seems inevitable.

Hockey skill videos (reference post)

Adult ice hockey is a new hobby. Unsurprisingly there are lots of adult no-checking leagues in the Twin Cities, JMS Hockey is the one I went with. Actually, I should say “we” went with. My #1 son is 18 now, and he is the first identified special needs adult hockey player in our league. We play on the same line — he plays at the top range of the “lower level” games and I’m at the bottom. After more than 10 years of managing his hockey teams and even becoming a level 1 coach (no skills required) I finally got off the bench.

Despite growing up in Montreal when Les Habs ruled hockey I’m a lousy hockey player. Fortunately I’m not a bad skater, though lately somewhat knee impaired. So I’m trying to pick up some stick handling skills.

This blog post is where I’m going to put the video links and references I like — largely from HowToHockey.com [1] and a UK(!) Hockey Tutorial I’ll update it over the season (assuming I last).

Basic snapshot and wrist shot (because this is so embarrassing right now)

Wrist shot

Most basic shot, what I’m learning now. When learning face the puck.

• How To Take A Wrist Shot
• How To Take A Wrist Shot In Hockey For Beginners | Hockey Tutorial
• Two Types of Wrist Shots
• How To Improve Wrist Shot Accuracy

Snap Shot

Quick shot taken when skating to net, face the net, puck to the side.

• How to take a Snapshot in Hockey
• How to take a snap shot in hockey for beginners | Hockey Tutorial
• How to Take a Snapshot - Off Ice Tutorial

Other

• Don’t shoot the puck
• How to Raise the Puck and improve your accuracy
• How to lift the puck of the ice in hockey and score more goals | Hockey Tutorial
• How to Work on Your Shot Inside (without breaking stuff!)
• Simple Tips to Improve Your Shooting at Home
• How to Shoot While Skating

[1] There are many books and videos on mountain biking skills. Hockey players don’t generally do that kind of thing.

Car stereo and price hiding: Buy from Crutchfield but hire an installer.

Our car stereo died a few weeks ago. Wire cutter liked a model that seemed to fit our needs, the Pioneer DEH-X6800BT (Owners manual, I save these on my iPhone) was $112 at both Best Buy and Crutchfield. I didn’t want to do my own installation, so I bought it at Best Buy.

When it came time to do the installation Best Buy told me I needed to spend $70 for a kit — which they didn’t have. It turns out the same kit is bundled free of charge with the Crutchfield device. I can see why Best Buy exploits information asymmetry to hide the true cost of their services, but I think Crutchfield could market their price advantage a bit more. The Best Buy installers (Geek Squad) tell me they’ll do the install at the same price if I bring in the parts.

So now you know. 

(I’ve ordered the unit from Crutchfield, when it comes I’ll decide if I want to try the install myself. In their favor Best Buy is good at accepting returns, in this case an unopened return.)

Update 12/14/2015

After I studied the Crutchfield installation directions little red lights started going off. Especially given vague descriptions of tools I needed (not mentioned previously) and after I took a look at the wiring harness. So I decided to hire an expert.

Best Buy installers require payment in advance and they were booked out quite far. I found a local place with a single (very good) Yelp rating; same cost, quicker appointment, no advance payment and I felt more confident in them. The install took 45 minutes. I’m very glad I didn’t attempt it myself; the uneasy feeling I got from the Crutchfield online directions was well justified. I wonder if Crutchfield more-or-less expects people to pay someone to do the install.

My installer had no qualms about using the Crutchfield gear, he didn’t need anything else.

So after trial and error I’d recommend: 

1. Find a local installer and confirm they’ll work with the gear you bring.
2. Look at Wirecutter recommendations. Emily wanted CD so narrowed it down. 
3. Order from Crutchfield. They bundle installation gear so was $70 less than Best Buy. 
4. Pay expert to install. Locally I’d recommend this place.

The car stereo seems fine. I won’t do a full review (no time!), but only negatives were a default color change pattern only a teenage boy would appreciate and finding that the Pandora features don’t work with iPhone if you choose Bluetooth connectivity. The former is fixable in settings; the manual doesn’t mention this but you can easily set the display a neutral white. The latter wasn’t a big deal.

 

There’s a huge volume shift from Bluetooth to FM Radio; when I switched sources I almost blew my stock speakers out. 

 

Update 12/16/2015

• The bluetooth connection is messing up Siri, it’s way less reliable. I know of a similar problem with a different BT user. I’m probably going to disable the BT connection and connect via USB.
• The faceplate won’t come off, it’s stuck on the left side. My installer class that’s a problem with the (free) Crutchfield cage.
• The UI is pretty awkward, but I’ll figure it out.
• My Amazon review, including volume issues. I’m going to switch to using the USB/power cable and see if the volume/Siri problems are better.

See also

• Sony Car FM/CD Head Unit: iPod/Audio-In/USB Car FM/CD Stereo: a review 3/2007. For historic interest.

The impossible machine

The immune system is an impossible, incomprehensible, machine. It is not even a ’system’ — evolution is not so modular. We name it as a thing so we can model it, but it is not made by a mind. It is made by evolution, so it is bizarre and emergent. Like a machine that pumps water and makes potato chips on the downstroke.

The thing we name, which is in truth not a bounded thing, allows us to exist, briefly, in a seething sea of self-organizing energy. Presumably its antecedents emerged with the bounded sack of water we call a cell. It has grown in complexity since then, a complexity that often resembles the nervous system. It is, after all, a processing machine. Brains must tell lies from truth, the immune system must distinguish friend from enemy from frenemy. It must often attack the non-self, except when the non-self is a fetus. It should not attack the parts of the self, except when those parts are broken or rogue. It ages as the body ages, but even as it grows frail the body grows more rogue.

Sometimes the non-self is a frenemy, at least for the moment. We are walking biomes, ecosystems in motion. Billions of microbes live within us, often helpful, sometimes the enemy of our enemy. Except when they turn on us. The immune system must manage this, even as the enemies and frenemies adopt the face of the self.

We created the idea of the immune system, and we created the idea of diseases of the immune system — though the boundary between disease and individual variation is not sharp. Some immune systems are poor at stopping some enemies — we usually die then. At other times the immune system confuses self and non-self, and it turns on the organism. We call this an auto-immune disease.

We can do very little about auto-immune diseases. System Lupus Erythematosis is a classic of this genre, our treatment has changed very little in thirty years. We have some newer treatments for diseases like rheumatoid and psoriatic arthritis, but our treatments don’t correct the error of the immune system, they merely induce selective immune dysfunction to slow the progress of disease. We know so little. We aren’t even quite sure that there isn’t some bizarre infection lurking in the tissues of affected people; maybe sometimes the immune system has the right idea but the wrong execution.

Auto-immune diseases are common. We used to think osteoarthritis was a disease of aging tissues, of wear and tear. Now we think this name we made contains multitudes, some related to aging, others to an attack of self on self (“erosive inflammatory OA”). We have no truly effective treatments for these conditions. We don’t even know if sleep and exercise are a good idea — what strengthens healing also strengthens the enemy within. The war on joints and tendons wears on the body, inducing metabolic syndromes and accelerating aging.

If we could reverse auto-immunity, if we could re-induce tolerance, we might be able to manage organ transplants and even stop the enemy within. Inducing tolerance is now an active research area — at least in rats. We have a very long way to go. I hope the next 30 years improves on the last 30, but we have had many false starts.

Related RSS feeds (for Feedbin, Feedly, etc).

• inducing self-tolerance in arthritic disorders.
• peptide-based immune tolerance induction
• Immune tolerance - therapy (very broad)

See also

• app.net thread: inducing tolerance might be rather like (re)training a neural network. The immune system as neural network analogy dates back to at least 1997.

Resurrect anthropology

One of my big disappointments of past 15 years is absence of falsifiable models of factors that create and sustain Daesh and kin. 

Anthropology died in the 80s. We need to drag it out of the grave and apply high voltage with a serum of empirical economics, political science and geography. 

Or we can keep floundering.

Scott Moses' FP Notebook is an astounding, and free, medical reference

Want to double check your doctor’s approach to your cholesterol problem?

Try this Family Practice Notebook (FPN) entry …

Hypercholesterolemia

… VII. Management: Less than two Cardiac Risk Factors

Cholesterol Management
Goal if LDL Cholesterol below 160 mg/dl (ideally <130)
Low Fat Diet if LDL Cholesterol over 160 mg/dl
Anti-hyperlipidemic if LDL Cholesterol over 190 mg/dl

Monitoring
Desirable lipids: Repeat Lipid panel in 5 years
Borderline lipids: Repeat lipid panel in 1 year
Elevated lipids: Repeat lipid panel in 3-6 months…

Or take a look at the cardiovascular medicine book. (In FPN-speak a “book” is a collection of topics, they are accessible from the top right menu.) Ok, I admit there’s a lot of implicit knowledge in those terse phrases. FP Notebook isn’t aimed at consumers, it’s written for family physicians, though it also works for internists and pediatricians. If you’re not a physician you may have to take my word for it — this is an efficient high quality information source for “up to date” (more on that below) evidence-based US medical practice. It’s also a one man show of epic scale (emphases mine)…

About FP Notebook

… This site is derived from a peripheral brain collection of medical notes and is divided over 5700 topics within over 600 chapters and 31 subspecialty books. Information is gleaned from reputable sources, referenced where possible, taken from lectures and workshops, peer reviewed articles and bulletins, and key texts.

… This site is personally funded by the site author, Scott Moses, MD. Additional funding is obtained via advertising support; all paid advertisements are clearly delineated as such. Our advertising related privacy policy may be reviewed at here

Please let us know if you find any advertising to be distasteful or inappropriate, or which you find dilutes the value or integrity of this web site. Absolutely no content on the site is influenced or authored by advertisers. Content is solely per the discretion of the site author….

… These medical notes began as a few scattered pearls of text stored with the Notetaker application of the HP Palmtop 200LX. Since 1995, notes from conferences, articles, textbooks and colleagues have accumulated to its current state.

As the collection of text grew, so did the complexity of its organization, and a program known as Brains was developed as a stand alone application for notetaking and for compilation of the website.

Brains is able to import raw text from the database, process the outlines, titles and synonyms, as well as images and links.

In its third iteration, Brains is written in C# with a SQL Server database and can output each of the site versions of html in 1-2 hours. This latest version also allows topics to be linked to the UMLS metathesaurus codes, and to be viewed on handheld devices.

… Most images on the site I have created myself. Many of the anatomy images were created using the 3d models from Zyogote. Others use a combination of Adobe Illustrator, Photoshop and Poser software.

When images are used from other sources, they are clearly cited. These include the NIH Virtual Human project and MedPix

… Gray’s Anatomy 20th edition from 1918 (Lewis) is in the public domain following expiration of its patent. Scanned images of the plates are available online at both bartleby.com and Yahoo.

In 2012, I started an anatomy series using the Zygote 3D models. I will provide 2 sizes of these images: 800x600 and 4096x3112 (poster size). I have maintained a margin on poster size images, such that they can be printed at 8x10,16x20, and 20x30 inches without losing content when cropping. Costco prints a 20x30 image for about $8.

You may use these images freely for printing (e.g. classroom poster) as well as presentations (e.g. Powerpoint) as long as they are not re-sold or modified…The author of the Family Practice Notebook, is Scott Moses, MD, a board-certified Family Physician practicing in Lino Lakes, Minnesota.

I think this is his hobby. Some people build cabinets, Dr Moses builds textbooks.

There’s really nothing like this any more - FPNotebook is a relic of a bygone world. Twenty years ago, when he started, there were quite a few free online medical references. I did a small one myself, many better ones were published by medical schools and hospitals. For a while some medical textbooks were available online for low costs, often bundled into services like MD Consult. That’s all gone now; Wolter-Kluwers Up To Date has replace many textbooks and online resources - at $500/year for an individual subscription. Once free references, like American Family Physician, are now buried behind paywalls (thereby raising a bit of revenue but sacrificing much good will).

Even if you have a subscription to Up To Date, perhaps through your institution, I suspect you’d find much to like in FPN. For example, take a look at the updates page including the May 2015 FAST exam update: “Test Sensitivity may be as low as 22% for abdominal free fluid in blunt Trauma”. Want to keep abreast of meaningful changes to American medical care? Forget those expensive newsletters, just subscribe to the (new) updates feed: http://fpnotebook.com/updates.xml. What a painless way to keep up.

Ok, you get the idea. This is an awesome resource — but how reliable can it possibly be? As Dr Moses notes, it’s entirely dependent on his vigilance and email feedback — nobody has volunteered to do peer review. I can give a partial response — because 10 weeks ago I started doing serious studying for my Family Medicine board exam. I last did family practice in 1994 and I don’t have an institutional subscription to Up To Date, so I used FP Notebook as a supplement to traditional texts, American Family Physician, and examination critiques. Over those weeks I covered a lot of family medicine in FPN; the only error I found was a minor misplaced section heading (an obvious copy/paste error that wouldn’t confuse any physician). I (and many others) found more mistakes in the closely edited ABFM exam critiques. There must be mistakes in 5.700 topics — but that’s an impressive record. I wouldn’t use FPN as my only guide to patient care, but I can testify to its excellence as a study and memory aid — and as a guide to what’s new and important.

FP Notebook is a dinosaur — straight out of Jurassic World, stomping over the puny mammals of the  modern web.

Try it, you’ll like it. (And say thanks — perhaps suggesting Dr Moses add a donation button. If nothing else, a charity donation button?)

Randall Munroe introduces world language and Google Translate training program using charming New Yorker article

XKCD’s Randall Munroe, the notorious interstellar sAI, has published a simplified vocabulary explanation of Special and General Relativity in the New Yorker.

This work is presumably taken from his almost released new book, Thing Explainer ($15 Amazon pre-order). The essay is entertaining and educational; it also promotes his new book and shows he is a smart pants man.

But that’s not the real reason he’s written this. Obviously his true agenda is to create an English dialect of a universal human language with a simplified vocabulary and grammar that is ideally suited to machine translation and, eventually, colloquial conversations with terrestrial AIs (contra the Wolfram Language for AI conversation, see also Marain. Siri-speak 2015 is a crude version of this.)

Let’s see how well his first version works, using the nsAI Google Translate to do round trip translations of a sample paragraph from the original muEnglish to another language and then back again. We’ll start with French, a language related to that of England’s 11th century conquerors, then we’ll do Chinese. I know from past experiments that round-trip translations from English to Chinese and back typically produce incomprehensible gibberish:

Munroe original (muEnglish)

The first idea is called the special idea, because it covers only a few special parts of space and time. The other one—the big idea—covers all the stuff that is left out by the special idea. The big idea is a lot harder to understand than the special one. People who are good at numbers can use the special idea to answer questions pretty easily, but you have to know a lot about numbers to do anything with the big idea. To understand the big idea—the hard one—it helps to understand the special idea first.

French version

La première idée est appelé l'idée particulière, car elle ne couvre que quelques pièces spéciales de l'espace et du temps. Celui-la grande idée-couvre l'autre tous les trucs qui est laissé par l'idée particulière. La grande idée est beaucoup plus difficile à comprendre que le spécial. Les gens qui sont bons à numéros peuvent utiliser l'idée spéciale pour répondre à des questions assez facilement, mais vous devez savoir beaucoup sur les numéros de faire quelque chose avec la grande idée. Pour comprendre la grande idée-le dur-elle aide à comprendre l'idée première spéciale.

French to English

The first idea is called the particular idea because it covers only a few special pieces of space and time. This great idea covers the other all the stuff that is left by the particular idea. The big idea is much harder to understand than the special. People who are good at numbers can use special idea to answer questions fairly easily, but you should know a lot about the numbers to do something with the big idea. To understand the great idea - hard - it helps to understand the first special idea.

Chinese

第一个想法就是所谓的特殊的想法，因为它涵盖的空间和时间只有几个特殊部位。另外一个大的想法，涵盖了所有剩下的由特殊的想法的东西。大的想法是很多更难理解比特殊的一个。人们谁是善于号码可以使用特殊的想法很容易回答的问题，但是你要知道很多关于数字做的大创意什么。为了解大的想法，硬一它有助于先了解特殊的想法

Chinese to English

The first idea is the idea of so-called special because the space and time it covers only a few special parts. Another big idea, covering all rest of the stuff from the special idea. Big idea is a lot more difficult to understand than the special one. People who are good at numbers you can use special idea is very easy question to answer, but you know a lot about what the figures do big ideas. To understand the big idea, hard and it helps to understand the idea of a special.

Munroe English (muEnglish) works rather well between French and English. If you’re interested in learning French, you might enjoy reading a future French version of Thing Explainer or simply run the English version through Google Translate (and use speech recognition for verbal work).

The Chinese round-trip experiment almost works, but falls apart grammatically. For example, “you can use special idea is very easy question to answer, but you know a lot about what the figures do big ideas” is missing things like “need” and “to” and a few pronouns. There’s also an unfortunate “numbers” to “figures” word substitution. Given that Munroe is a far more advanced AI than Google this essay will be used to enhance Google’s Chinese translation model (which desperately needs work).

I’m optimistic about this new language and happy that the Munroe is now taking a more active hand in guiding human development. Zorgon knows we need the help.

Update 11/19/2015: There’s a flaw in my logic.

Alas, I didn’t think this through. There’s a reason speech recognition and natural language processing work better with longer, more technical words. It’s because short English words are often homonyms; they have multiple meanings and so can only be understood in context [1]. Big, for example, can refer to size or importance. In order to get under 1000 words Munroe uses many context tricks, including colloquialisms like “good at numbers” (meaning “good at mathematics”). His 1000 word “simple” vocabulary just pushes the meaning problem from words into context and grammar — a much harder challenge for translation than mere vocabulary.

So this essay might be a Google Translate training tool — but it’s no surprise it doesn’t serve the round-trip to Chinese. It is a hard translation challenge, not an easy one.

[1] Scientology’s L Ron Hubbard had a deep loathing for words with multiple or unclear meanings, presumably including homonyms. He banned them from Scientology grade school education. Ironically this is hard to Google because so many people confuse “ad hominem attack” with homonym.

Mountain biking - crash and ride safety tips from Bicycling.

Bicycling Magazine has a surprisingly strong article aimed especially at mountain biker riding solo:

7 Things EMTs Wish You Knew about Bike Crashes (My instapaper link)

You always need to take an impact to the head seriously.” … call 911 if you or another rider has:
• ... a cracked helmet. That means you’ve hit your head hard.• ... a headache. Not just sore from the initial impact, but you have a headache that isn’t abating or is worsening.• ... lost consciousness. If you pass out, you need to get checked out.• ... confusion. If you don’t know who the president is or why you’re sitting on the side of the road, you need to get checked out.• ... vision changes. If the world doesn’t appear clear and normal, you need medical assistance.

Take a Deep Breath: Difficulty breathing is always an emergency situation. “Too often people crash and think they’ve cracked a rib, but figure ‘Why go to the hospital? They can’t do anything about it,’” says Martin. “But you need to go because those cracked ribs can have sharp edges and if it’s an unstable fracture and it shifts, you can puncture a lung.” If it hurts to take a deep breath, get to the ER.

Give Yourself a Gut Check: There’s a lot of vulnerable soft tissue and plenty of vital organs in your belly that can be damaged by impact with a handlebar. Take your hands and palpate your abdominal area. If you have an area that is more tender than others, you could have internal damage. If your belly becomes distended or firm, that’s a sign that you could have internal bleeding and need medical assistance stat.

Stop the Bleeding: Unless you’re a trained professional, forget what you’ve seen in the movies about fashioning a tourniquet around a limb to stop the bleeding. You risk doing more damage than good. The best way to deal with bleeding is basic first aid—direct pressure (preferably with something clean) on the wound. Keep it there till help arrives.

Be Smart About Your Spine: Neck and back injuries are scary. You can generally tell if you’re okay by checking your fingers and toes. Obviously, you want to be able to feel your fingers and toes, but if you have any numbness and/or tingling, that’s not good. You could have spinal injury. Also try slowly turning your head 45 degrees to the left and right. If you feel discomfort, stop. That’s also a sign of spinal injury. Get to the ER.

Make Your Personal Info Accessible: Whether you use Road ID, dog tags, or place ICE ('in case of emergency') information in your cell phone, having your personal information available for emergency workers can definitely save your life, says Martin. “We need to know your medications and your allergies," he says. "There are a lot of medications we can’t give you if you’re allergic to them… and we won’t give them if we don’t know.” New iPhones come with a Health app that provides a place for you to fill in all your medical information. Emergency personnel can access this information without unlocking your phone. “We know to look for it if you’re out there by yourself, unconscious, after a crash,” says Martin.

Leave a Note, or a Text: Riding alone? Take two seconds to leave a note or shoot a text to a loved one or buddy. “We’re all guilty of this,” says Martin. “We go out for a quick ride and nobody knows where we’re going. Even if you’re just 10 miles away, you might as well be 100 miles away if no one knows where you are.” The more remote of a place you ride, the more important this is.

It’s always safest to have a ride partner, but next best is to ride on well marked and trafficked trails. Riding on lesser traveled wilderness trails kicks the risk up several notches, just as with wilderness hiking or scrambling. Note the unstated implication of these recommendations is that you have a working cell phone and can call for help or advice after injury.

The iPhone Medical ID locked device access feature is obscure. You have to know to swipe to unlock then to tap the Emergency button then to look below the call keyboard and tap “Medical ID”. I hope EMTs are trained to do this. Apple forgot to enable Siri access, “whose phone is this” works on a locked phone, but “show me Medical ID” does not. I enabled Medical ID, but my phone’s lock screen has my contact info, more importantly, my wife’s cell number as Emergency contact. That was easy to do — I filled it out in iMessage, then took a screen shot, then made the screenshot my lock screen background. I need to check that I’ve set it up for my kids.

Sharing location on an iPhone using iMessage is easy, but also a bit obscure. You need to start with an existing message thread then tap the wee “i” icon top right. Just text that at start of a ride somewhere, update if you wish. I have Find Friend enabled, so if that works my family can track me (but they tend not to think of it).

Self-assessment with a head injury is tricky. I’ve had a concussion (inline skating actually), and it doesn’t help one’s judgment. If you whack your head out in the trail you should probably call in to a friend and have them check your thought processes. You may need to ride out before you can do anything more formal (assuming you can ride!).

Good stuff.

Trump explained: Non-college white Americans now have higher middle-aged death rates than black Americans

From today’s NYT Health section:

Death Rates Rising for Middle-Aged White Americans. Gina Kolata Nov 2, 2015

… middle-aged white Americans. Unlike every other age group, unlike every other racial and ethnic group, unlike their counterparts in other rich countries, death rates in this group have been rising, not falling…

… two Princeton economists, Angus Deaton… and Anne Case. Analyzing health and mortality data from the Centers for Disease Control and Prevention and from other sources, they concluded that rising annual death rates among this group are being driven … by an epidemic of suicides and afflictions stemming from substance abuse: alcoholic liver disease and overdoses of heroin and prescription opioids…

… the declining health and fortunes of poorly educated American whites. In middle age, they are dying at such a high rate that they are increasing the death rate for the entire group of middle-aged white Americans…

… The mortality rate for whites 45 to 54 years old with no more than a high school education increased by 134 deaths per 100,000 people from 1999 to 2014.

The article falls apart a bit here. What we want to know is how the absolute death rate for non-college middle-aged white Americans in 2013 and in 1999.  We want to know how the Long Stagnation has changed vulnerable Americans, but Kolata’s article mixes all white Americans with the no-college cohort.

Fortunately the PNAS article PDF is freely available, but unfortunately it explains Kolata’s problem — the data we want seems to be buried in an unlabeled parenthesis in Table 1. From that I think I can reconstruct the key information: [1]. 

Year	White no college	Black (all)	White some college	White BA+	White All
1999	601	797	291	235	381
2013	736	582	288	178	415

For the no-college White American 1999 was a pretty good year; probably the best ever. That was the era of NASCAR America and the candidacy of GWB, champion of the “regular” white guy. Employment demand was high and wages were rising. Yes, as a white guy without any college you had a shorter lifespan than the minority of white (Americans) with a college degree, but at least black Americans were even worse off. It’s always comforting to have someone to look down on.

After 16 years of the Great Stagnation though, things are different. Suicide and substance abuse have pushed no-college white mortality to the level of 1999 black Americans, yet during the same period black American middle-aged mortality has fallen substantially. White no-college Americans are now at the bottom of the heap [1].

This is why we have the inchoate white rage that thunders through the GOP. This is why we have Donald Trump.

A large and culturally powerful part of America is in crisis. A cohort with lots of guns and a history of violence. Maybe we should pay attention. Trump is a signal.

- fn - 

[1] There was no breakdown of black death rates by education; a 2012 census report said 29% of whites and 18% of blacks had a BA or higher. Since 80%+ of black Americans have no BA it’s likely no-college whites now have higher middle-aged mortality than no-college blacks.

See also

• Gordon's Notes: Donald Trump is a sign of a healthy democracy. Really. 8/2015

Update 11/4/2015

There’s been considerable coverage of this story, but it’s been disappointing. Both DeLong and Krugman missed the college vs. no-college white middle-age cohort, and I think that’s the important story. There’s also been some discussion of anger as a defining trait of the GOP base, but no connection to the extreme distress of their core voter.

I’ve seen speculation that this is all about narcotic overuse. I find that very hard to believe, but I admit the use of narcotics for pain relief in America has exceeded my expectations. I remember in the 90s when “pain is the new vital sign” and family docs were berated for inadequate use of narcotics. I guess my peers responded well to that feedback.

It has occurred to me that there’s a potential bias we’re missing. Over the past 40 years colleges have gone from predominantly male to predominantly female. The big story here is increasing mortality in the no-college white cohort. But if there’s been a gender shift in that cohort, say from 55% female in 1999 to 45% female in 2013, that will make the no-college numbers even more dramatic. Since mortality has increased even when college grads are included this isn’t the entire story, but it will make the no-college effect more dramatic.

Capitalism, fraud and maximizing wantability

WaPo has a delightfully meta-subversive headline for an article about the failings of 21st century capitalism: This Kardashian headline shows why two Nobel winners say the economy is broken. Beneath the headline is a photograph of 3 reasonably attractive women and the hit enhancing text “Kourtney, Kim and Khloe — arrive at the Maxim Hot 100 party”.

Jeff Guo’s article proceeds to an interview with Akerloff and Shiller, reasonably well regarded academic economists, about their book Phishing for Phools. Unfortunately Guo does get around to the Kardashians, which blunts the beauty of the introduction. Still, it is a lovely bit of meta; boosting page hits for an article about how easily humans are manipulated in the interests of feeding their wants.

Shockingly, it seems capitalism does not optimize our better selves.

I’ll let that sink in a bit.

Sure, you think it’s obvious that capitalism is a system for finding local minima traps in a 3 dimensional field where demand is gravity and information technology enables complexity enables deception. If pressed to respond further you might say something like “tobacco”.

It’s not obvious to Americans though. Our culture equates wealth with virtue, and the “invisible hand” of capitalism with the “invisible hand” of a Calvinistic God. It’s an authoritian-dominance attractor in culture-space, and we’re not the only people to get stuck in it.

So this is an article worth scanning, if only as a marker for the fading glamor of the 1990s capitalist (emphases mine) …

… Economics predicts that wherever there is a profit, someone will be there to make it. To that, Akerlof and Shiller propose a corollary: Wherever there is an opportunity to profit off people’s weaknesses, someone will exploit it…

… The basic idea of this book is that there is a “phishing” equilibrium, in which if there’s a profit to be made by taking advantage of your weakness, then that will be there.

… The standard view of markets (which is subject to problems of income distribution and externalities) is that markets will deliver the best possible outcome.

… that’s what the standard graduate student is taught. It’s what you’re told to believe, and what I think most economists do believe. As long as the markets are competitive, and there are no problems of income distribution and there are no externalities, it’s going to lead to the best possible world…

… that then has acquired a moral tone, which is that whatever happens in the market is okay. And that translates, in turn, into people arguing and thinking that it’s okay to be selfish. That if I earn this income, then I in some sense deserve it.

So this view that whatever markets do is good becomes this idea that whatever markets do is right…

… Kirman tracing the origins of this idea back to the Enlightenment. He says, “laissez faire made a lot of sense against the background of monarchy and controlling church.” So this idea of freeing the markets really came through at a time when businesses were being particularly oppressed….

… Irving Fisher was a Yale economist who in 1918 wrote a book saying the free market system is maximizing something but it’s not what Jeremy Bentham, the philosopher, called utility. So he named it wantability.

I did a Google N-grams search [how often a word appears in books] for wantability. The term enjoyed some popularity in the 1920s and 1930s, then exponentially decayed. After the Reagan-Thatcher revolution the term was gone….

… the children’s candy bars were put at children’s eye level …You have professionals who are designing everything. They are designing it for wantability.

Reading this a part of me thinks I should get a Nobel just for my blog rants. Economists don’t think market solutions have local minima traps? It’s novel to think markets produce things that are bad for us? Stockholm, it’s not that hard to find my real identity. I would’t mind the money. You can give me another prize for canopy economics and eco-econ.

So this isn’t a book I’m likely to buy. It’s an interesting marker, however, of our changing attitudes towards market capitalism and for the intellectual history of our judgments from Adam Smith to Donald Trump. Twenty years of lousy economic growth (great for elite, awful for non-college) will do that. I’ll be looking for more signs of thoughtfulness …

See also

• IT and productivity - two noteworthy posts from Equitable Growth 2/2015 - good set of links to my older stuff.
• Learning from an Amazon “Newer Galaxy” fraud: I too am prey. 10/2015. Just this morning! I got caught. 

Learning from an Amazon "Newer Galaxy" fraud: I too am prey.

I’ve been digging into thunderbolt 2 lately. It’s an orphan technology — sure looks like Apple has given up on it. In retrospect either Apple or Intel needed to make their own hubs — in a low-trust world leaving this to dying 3rd party manufacturers was a mistake.

For now I’ve settled on the OWC Thunderbolt 2 dock. It’s not perfect, I still have suspicions about how it performs under load. I wouldn’t be surprised if I need to power cycle it every few days. Yeah, like I said, Apple needed to make this. I tested it next to an Elgato hub with similar USB 3 performance, the deciding feature was support for legacy firewire 800.

During the testing period I used a (too) short thunderbolt cable bundled with the Elgato, but that’s going back with the return. Due to a misunderstanding about Apple cable prices I decided to get a OWC 2m cable, but in a moment of weakness I ordered it from Amazon (Prime shipping, speed, etc).

That is, I ordered from an Amazon page that said OWC cable on it, via “Newer Galaxy Distribution Company”. The page looked like this:

Yeah, look closely, It says made by OWC and the image has OWC on it, but the page title doesn’t actually say OWC. On the other hand, the text says:

Utilizes the latest Thunderbolt chipset for high-speed 10Gb/s Thunderbolt and 20Gb/s Thunderbolt 2 devices
Enhance video workflows with support for faster 4K video transfers + 4K display capabilities via DisplayPort 1.2
1 Year OWC Limited Warranty

So I was stupid, yes, but I wasn’t completely misguided. I even inspected “Newer Galaxy”’s sales count and ratings — though I know ratings systems of this sort are almost completely fake.

Damn. I know better than this. Yes, it was Amazon Prime, but that only means the returns are easier. It doesn’t mean it’s legitimate.

This is what’s being shipped:

A “2M” cable. It’s not actually a counterfeit cable at this point, it’s just not what I ordered.

There’s an upside to this experience. I can share it here for one, and every story like this is a small push for Amazon reform. Amazon returns are very easy, and for frauds like this there’s no return postage fee. (I’ll reference this blog post in the return comments.)

For another, I’ve also learned that I’m not as good at spotting fraud as I should be — I blame that on age. The data is clear that most of us become prey after age 55 or so. Prey have to learn fear, and I’m learning.

Best of all I learned that Apple has dropped its price on 2m thunderbolt cables from $60 to $40 (that price drop is probably why trustworthy alternatives have disappeared). So I’ll do that instead.

It would be good to have a trustworthy alternative to Amazon… 

Apple blogs: please stop confusing Apple shareholders with Apple customers

Apple made bazillions again. They won’t pay corporate tax on it. The share price has gone up.

That’s good for me in one way — I own index funds that hold Apple shares. On balance when those shares go up or Apple pays dividends I get more money. Yay for me, though I’d do just as well if the money went to, say, Microsoft or Google. My index funds own their shares too. So only a little Yay.

Whatever wealth I gain or lose from a change in Apple’s share price, however, is dwarfed by the money I spend on Apple products. Three laptops (one recently expired iMac), five iPhones, Airports, Apple TV, iTunes movies and TV shows and so on. That direct cost is exceeded by the life-time I spend managing Apple’s defects, quality issues, and nastily executed strategic killings. I think on balance I come out ahead — but some days I’m not so sure. The gap is smaller than it used to be.

As an Apple shareholder I’m mildly pleased with Apple. As an Apple customer though, I’m not so pleased. The Apple Watch leaves me cold. Using data lock customer retention while killing products (yeah, Aperture) without a replacement is just bad. The iPad should have been multi-user years ago. 3D Touch isn’t worth the cost, complexity and weight. The iBook mess. The nuttiness of putting a mechanical hard drive and a very expensive display in a non-serviceable iMac. Meanwhile Apple’s traditional 20% cost premium is turning into a 40% premium.

As an Apple customer I’d like to see Apple’s share price fall 20% - as long as one of my other funds gets the value instead. A falling share price might promote interest in existing customers.

So, Apple blogs, please stop paying so much attention to Apple’s share price. It’s just not that important to me.

Quicken spending spam - alert "feature"

In my mail this morning…

During a machine transition I reinstalled Quicken 2015, so I at first thought we’d unwittingly enabled Quicken Mobile and put our finances into Intuit’s Cloud. We hadn’t, but there’s an alerting “feature” I didn’t know about that can be changed in preferences. I’ve now disabled all alerts. 

I’d prefer Intuit (current owner, but Quicken has been abandoned) not know anything about me at all. I suspect knowing about me is, unfortunately, a significant part of their failing business model.

If you don’t want this, then stay away from Intuit and Quicken.

Preventive care: what's new in the past 7 years

While studying for my 2009 American Family Medicine board exams I wrote up a summary of the American Academy of Family Practice’s preventive care recommendations. For this November’s exam I updated my old notes, so I got to see what’s changed with preventive care over the past 7 years.

There are more listings now, but most of the additions are recommendations not to do anything. HPV and cervical cancer screening recommendations still don’t consider immunization status. Screening for diabetes in pregnancy was removed in 2008 (though everyone would still do it) but it’s back in 2015. Hep C screening is recommended for at risk or born 1945-65; that’s because we have decent treatments now. I was a bit surprised that HIV screening is now recommended for everyone age 18-65 — though the screening interval is murky. Screening used to be limited to higher risk populations.

Lung cancer went from “don’t screen” to equivocal, but PSA (prostate specific antigen) went from equivocal to “don’t screen” (remember when every senior guy needed that?).

And … that’s about it. Based on the news this week mammogram screening will be further reduced but that’s not part of the official recommendations yet.

Not a lot of change.