Tuesday, July 09, 2013

Bicycling in a deluge

Many years ago I road through a mini-flood downpour. Not the nearly 5" that drowned Toronto, but a fun storm. That was it for a long time. In our old midwestern climate a genuine deluge was really not that common. They were easy to dodge, and with fenders and some gear routine rainfall is no problem.

Things are different now. In the post-400 ppm CO2 world my weather is warmer and wetter; we are told to expect really heavy downpours more often. Like the one I hit last week on my routine commute. Instead of waiting for it to pass I rode on, and so I  found out what gear worked and what gear didn't.

Didn't work
  • Old baggies: They degrade with age. The ones I had in my front bag were worthless
  • My brakes and my vision: Of course both brakes and vision degrade in rain, but in a deluge they really do nothing. This was a bit of a problem because in 3" of a groundwater collection my tires didn't have much traction, and I couldn't see a big pothole under the floodwater. So I went down.
  • My GoreTex shoe covers: They didn't work because I didn't put them on. That was dumb -- my shoes didn't dry off for a couple of days. Even though the rain was mostly fun, it would have been nice to have dry shoes for my return trip.
  • My panniers: They do well in routine rainfall, but I knew they weren't waterproof. I poured a half-inch of water out of my front bag. My wallet, keys (no electronic fob!) and several maps were soaked; I tossed the maps.

Worked

  • My waterproof iPhone 5 case: Best $15 I've ever spent. If not for that case my phone would have been ruined. I leave it in my bike bag.
  • A rubber lined "conference bag" that I was carrying my work laptop in the rear panniers. This was dumb luck, I had no idea that bag was so water resistant. If I'd been thinking I'd have waited out the heavy rain rather than chance losing the laptop.
  • Fenders: No wheel tracks, though in that amount of rain I suppose they'd have washed off.
  • My yellow rain jacket and lights; Not sure the lights were visible, but I think the jacket was. In any case I opted for the sidewalk when the road narrowed, figured drivers couldn't see at all. I wasn't that worried about staying dry, but the ancient Nashbar jacked did that too.
  • Helmet and helmet cover: I bonked the helmet when I went down, which made me feel better about having it. Helmet cover worked better than I'd expected.
  • Synthetic clothes: Wow, that stuff dries well.
Falling was a drag, but I wasn't hurt and now I know what to look for - road floods are trouble. I should have moved to the nearby sidewalk. I had to relube my bike, but that's not a big deal (yay sealed bearings) - so, overall, it was kind of fun. Next time I'll have a canoe bag in my rear pannier -- something to hold wallet, keys, garage door opener, maps and similar items during a real downpour.

Saturday, July 06, 2013

National Library of Medicine adds PubReader - Instapaper for medical literature fans

I became a fan of the National Library of Medicine (NLM) when "Grateful Med" [2] augmented the old telnet interface to what was then MEDLARS/MEDLINE, and once was Index Medicus. Rose Marie Woodsmall recruited me to teach rural docs how to use Grateful Med --  which was kind of excruciating in the days before error correcting modems [1].

I loved it when the NLM added RSS feeds to PubMed results, so I could track research topics in my feed reader (still works in Feedbin/Reeder). That's where most of my app.net | pinboardkateva.org/sh [3] medical posts come from.

Most recently, in the post-2007 age of full text access, NLM has added an HTML5/CSS3 Instapaper-like view for reading articles on mobile or desktop. It's known as PubReader™ (emphases mine):

... view is available for any article that is available in full-text HTML form in PMC. It is not available for older content that is available only in PDF form or as scanned images of the original print pages. You can get to the PubReader view directly from an article citation in a search result list or an issue table of contents:

Or from the Formats links in the top right corner of an article page in PMC...

...  PMC now automatically directs certain users to the PubReader view:

- everyone using PMC on a tablet or mobile device, and
- a small, randomly selected sample of people using PMC on a desktop or laptop....

.. We start with the XML version of an article and use XSLT to convert it into an HTML document. We then add CSS and Javascript (JS) to implement the formatting, paging, navigation, text reflowing and other dynamic features. This, essentially, is the way we have created the traditional article display in PMC for years. The difference now is that we are able to take advantage of features and functions that are available only in the latest versions of the underlying technologies (HTML5 and CSS3).

The CSS and JS code used to create a PubReader presentation is available at the GitHub repository NCBITools/PubReader. Anyone can use or adapt it to display journal articles or other content that is structured as an HTML5 document.

Great service, neat technology.

Go NLM!

- fn -

[1] In response I reinvented software error correction in the early 80s. That seems stupid now as the work had been done decades before, but it's hard to remember what life was like before we could discover knowledge in seconds -- assuming we know the magic words.  We really don't understand, yet, how much that has changed our world.

[2] Rose Marie was a deadhead (probably still is), which was how the DOS, later MacOS, app got its name. In 1996 Internet Grateful Med, an early web app, displaced it. In the 00s we got today's PubMed.

[3] All of which have, I'm happy to say, RSS feeds -- even app.net which started out without. Kateva.org/sh is probably the best to follow with a feed reader.

See also:

Friday, July 05, 2013

Acute back strain management - one anecdote

After the 2008 vacation ambulance ride and the supine drive home I decided I needed to see a doctor other than myself. Twenty-five years of increasingly severe and transiently disabling back pain was enough. So I did, and I got better.
 
Which nobody wants to hear about. There's nothing more boring than back pain stories. Heck, when I first saw my back doc he cut me off at the start of my epic. He'd heard it all before. 
 
So nobody wants to hear my stories, but, honestly, if you have back pain you should read 'em [1]. I got anecdote, I got training, I got experience, and my current approach is consistent with PNBC's evidence-based back strength boot camp. By contrast much physician management of acute back strain is pretty weak.
 
This particular story is a bit different. In the past I'd sneeze or tie my shoes funny and be laid out for days. [2]. This time I was at the end of four sets of CrossFit front squats, lifting about 125 lbs. when I shifted forward a bit, tried to correct and felt my back tear (or whatever it's doing - we don't know). I dropped the bar and lay (grammar?) down on an ice pack. 
 
This is what I did for immediate post-injury recovery. This time I didn't need my old canes, and two doses of Motrin was plenty. I don't know if that's because I'm stronger than I once was or because this was a relatively minor injury.
  • Sunday (injury day): neoprene waist band and doubled cold pack. Walking and modified version of my usual morning stretch [4]. Inline skating in pm - that's often helpful for me [5]. Sleeping was difficult, though I've had much worse. Motrin 800mg midnight.
  • Monday: I am able to stand. Fear level diminishes.  Able to do most of stretch [4]. Continued ice. Evening skate with my son and the Minnesota Inline Skate Club. Start using Roman Chair for extension exercises, with arm assist. Motrin 600mg before bed.
  • Tuesday: I am able to do 85% of my usual stretch. Minimal ice. Two hour high speed bike ride from home to Minnehaha trail to Lake Harriet around and back. Roman Chair with minimal arm assist. No meds, sleep a bit sore.
  • Wednesday:  AM full stretch routine. 16yo and I go to weight room at JCC. There I can do arm workout, resisted back extension, abdominals with controlled equipment (not free weight). Full Roman Chair. In evening I'd scheduled a swim, but couldn't fit it in. PM stretch. Sleep good.
  • Thursday: AM stretch, otherwise day spent on chores and family duties. Full set of situps and Roman Chair. PM stretch.
  • Friday: AM stretch, AM CrossFit Yoga - extreme stretches. No pain. Two hour bike ride in evening with 16yo. Roman Chair and Situps. PM stretch. Back isn't normal, but it's pretty good.
  • Saturday (plan): Try running to barber shop in AM. PM family bike ride -- lots of lifting bikes, moving car seats. Good functional back test. 
  • Sunday (plan): Regular CrossFit -- will keep weights under 50 pounds (women's 18 or 33 lb bar).
As a rule a soft tissue injury at my age will take at least six weeks to heal. In addition it's clear that my back is going to need to get stronger before I go back over 100 lbs [6]. So my go forward recovery plan is:
  • Maximal weight 90lbs until my extension and abdominals are much stronger.
  • Ensure I have at least 3 days between my full CrossFit workouts. They are intense and I need that much time to recover; when I was hurt I had a 1 day gap. In between I do my bike rides, inline skating, and, now, gym weights.
  • More aggressive Roman Chair and situp training.
  • Add 1 day/week of workout in conventional gym with controlled equipment. I will establish my current baseline max for 6 rep extension and abdominal. I need to increase that by 30% before I go up again on free weight.
  • Consider adding a routine CrossFit Yoga session -- if I can find the time I think that would be a good complement in a couple of ways.
- fn -
 
[1] For example ...

[2] One of the little ironies of mortal life is that nature routinely does stuff to us that, when we do it to one another, could be considered a war crime.

[3] Why is CrossFit, and why am I doing this when I'm older than the moon? I've got a post pending on that.

[4] Every morning, 5 reps each for past five years: Knee to chest r/l, knee lateral hip rotation r/l, straight leg, two leg to chest, elbow press back extension, full arm back extension, cat stretch, sit rotate, hamstring stretch, quad stretch.

[5] Sounds bizarre, but when I've hurt my back it's a lot easier for me to skate than to walk. I'm a good skater. It also forces me past the fear that accompanies this kind of injury, especially for those of us with memories.

[6] My classes are about half female, and, prior to my injury, I lifted an average or above average amount for the female group. Bottom of the male group of course.

Update 3/19/2016

Despite developing an inflammatory osteoarthritis (yay) my back has done quite well over the past 3 years of CrossFit. I had another strain with deadlift in Jan of 2016 but it healed well. I think I took 1-2 weeks off CrossFit to do cyber-type weights at a different gym before returning to CrossFit. Year 8 post my great PNBC experience and 3 years of CrossFit St Paul my back is healthier than most people my age. 

 

Tuesday, July 02, 2013

American psychology and civil war in Egypt

An acquaintance from my Quebec High School is active in Egypt's secular resistance to Morsi's rule. She's frustrated by Obama's tolerance of the Muslim brotherhood; I think she would prefer the freedom rhetoric of Bush II. Personally, I prefer Obama.

That's not what's interesting though. The interesting bit is she seems genuinely confident that Egypt won't break down, like Syria and Iraq, into civil war. That confidence seems strange to an American, even an immigrant American like me. We believe in Civil War; we had a big one not long ago. There are still flare ups in old battlefields.

For an American it's easy to imagine Civil War in Egypt. There are many things that are strange to us, but not civil war.

Friday, June 28, 2013

Blogger.com and Wordpress.com traffic post the end of Google Reader

Inspired by this Rumproarious post on the effects of the Google Reader shutdown announcement of mid-March 2013 (data excludes custom domains hosted by blogger or wordpress).

Alexa: WordPress.com

 
Alexa: Blogger.com

That's ... impressive. I'm still puzzled that WordPress didn't have a stronger response to the Google Reader shutdown. My best guess is that they'd already decided to abandon the Wordpress.com business.

It will be interesting to return to this topic in six months. I'm amazed how many good alternatives have already emerged to Google Reader. I didn't think we'd have so many choices.

See also:

Saturday, June 22, 2013

Microcomputer redux

Once upon a time, in the 1970s, these were microcomputers:

""Microcomputer 1970

We called them micro-computers because we used the term mini-computers for things that were the size of refrigerators. So something the size of a microwave was, inevitably, "micro".

The term fell out of favor though. In a world where the personal supercomputer is 10" tall, micro seems redundant.

More recently, however, things have gotten smaller. A lot smaller. The KL02 "microcontroller" is shown here next to a Mac's letter L. (Does anyone else make computers other than Apple? No, I didn't think so.)

Freescalex299

I suppose it will be paired with a sand-grain sized 3D printed battery.

It's time to dust off an old word. Welcome back microcomputer.

Sunday, June 09, 2013

Cash purchases driving a new real estate bubble - too much wealth, too few investments

Cash-only real estate speculation in LA, Boston, Miami, San Francisco and so on (emphases mine) ...

... These days, the only way for would-be buyers to secure a home, it often seems, is to offer all cash and be ready to do so within hours, not days.

...first-time home buyers are competing with investors to get into single-family homes with prices approaching $1 million.

... large investors purchasing thousands of properties

... a third of all homes purchased in Los Angeles during the first quarter of this year went for all cash, compared with just 7 percent in 2007. In Miami, 65 percent of homes sold were for cash deals, compared with 16 percent six years ago.

... In Los Angeles, the median price on an all-cash home this year is about $351,000, compared with $230,000 in 2009. Over the same period, the median price over all increased to $410,000, up $85,000. In fact, last month, home prices in Southern California hit their highest level in the last five years.

... Buyers in Boston are offering $100,000 more than the asking price or placing offers on homes they have spent only minutes in.

... He also waived the inspection clause, an increasingly common practice... offers today are more likely to include escalation clauses, saying buyers will pay an additional amount over the highest bid.

... cash purchases fueled in part by international investors and retirees awash in cash after selling their homes elsewhere....

This fits reports a few months back of large numbers of purchased but unoccupied condominiums in luxury markets.

Where is all the cash coming from? The article doesn't say, but there's vast wealth in China now and few safe places to park it. Real estate is a classic Chinese investment. There's also a large amount of boomer wealth in play as my generation (noisily, because we are nothing if not loud) shuffles off the stage.

What happens next? I assume we're in for another one of our worldwide boom-bust cycles...

Gordon's Notes: Stock prices - resorting to another dumb hydraulic analogy

NewImage

Why are having these worldwide boom bust cycles? 

Ahh, if only we knew. Since I'm not an economist, and thus I have neither credibility to protect nor Krugman to fear, I'm free to speculate. I think the world's productive capacity has grown faster than the ability of our financial systems to manage it. There's too much wealth and potential wealth (in a fundamental sense, regardless of central bank actions) for our system to productively absorb. We're filling a 100 ml vial from a 10 liter bucket. Or, in Bernd Jendrissek's words: "The gain is too high for the phase shift for this feedback loop to be stable."

If there's anything to this idea then we little people may want to remember the advice of Victor Niederhoffer, a wealthy man who has lost vast amounts of money in the post RCIIIT economy:

... Whenever disaster strikes, the very sagacious wealthy people take their canes, and they hobble down from their stately mansions on Fifth Avenue, and they buy stocks to the extent of their bank balances, and then a week or two later, the market rises, they deposit the overplus in their accounts, invest it in blue-chip real estate, and retire back to their stately mansions. That's probably the best way of making money, to be a specialist in panics. Whenever there's panic hanging in the air, that's a great time to invest...

Of course this implies one has a relatively tax efficient way of moving money in and out of cash -- and lots of cash to gamble without fear of unemployment. When downturns hit most of us need our cash as a hedge against job loss; only the 0.05% don't need to work. Even so, there may be a lesser version of the long game we can play to at least limit our crash pain. For example, perhaps a 21st century John Bogle will create a derivative that retail investors can purchase on the rise (when we have cash) that pays off on the fall (when we don't).

How long will it be before the world's financial systems catch up with our productive capacity -- especially given the rise of Africa and the unfolding of the post-AI world?

I suspect not in my lifetime [1]. It's whitewater as far as the eye can see.

Update: In surfing lingo a hard breaking wave is a called a "Cruncher". Perhaps "new Cruncher" is a better term than "new bubble".

- fn -

[1] Though if wealth were better distributed we might have the equivalent of filling that 100 ml vial from 10,000 1 ml vials. Much easier to stop before overfilling.

Tuesday, June 04, 2013

Was AirPort Utility 6 the start of Apple's year of drifting dangerously?

I used Pacifist to install Airport Utility 5.6 when I upgraded to Mountain Lion. So I didn't really notice how many features Apple removed with the Mountain Lion/Airport Utility 6 upgrade. 

Recently though, I wearied of having to restart my (only) 3 yo Time Capsule every 4-6 days to reenable Time Machine backups. I ordered a new TC from Amazon to do a hardware swap test (30 day return) and, for no good reason, I tried using Airport Utility 6.2 to configure things.

It was an abysmal failure. To start with, it failed with a meaningless error message when it tried to join my existing network. For another I couldn't archive my Time Capsule backup -- and I couldn't disconnect guests and backups prior to power down. A Jan 2012 CNET article has the long list of lost features -- not to mention support for older devices.

In retrospect, Airport Utility 6 was a big initial step in a trek that included the iOS podcast.app and iTunes regressions (though some functionality was restored to iTunes). January 2012 was the start of what has been a long and disappointing 15 months for customers like me.

WWDC 2013 will tell us if Apple is going to change direction.

I hope the rumored Microsoft shakeup is a very big one. I have a bad feeling I'm going to need them.

Saturday, June 01, 2013

What pedestrians and cyclists can do while we wait for the end of human drivers

After 40 years of biking with cars, and almost as long driving with them, I cannot avoid the obvious.

Humans cannot drive cars safely around anything smaller than a Honda Civic.

This is not a matter of rules or training. We could make violation of the three foot passing rule a capital crime and cars would still pass too close to pedestrians and cyclists. Even without benefit of age, smartphones or alcohol human drivers will signal left and go straight, open driver side doors into oncoming bicyclists, and do rolling stops through pedestrians. Human drivers will continue to not see motorcycles, pedestrians, or bikes.

Our evolutionary history didn't prepare us for the job of driving cars. Non-armored road travelers need the Google driverless car; within a few years of its affordable introduction friends won't left friends drive. Shortly thereafter human drivers will become uninsurable. (Shortly after that humans may lose the right to vote, but that's another post :-).

Alas, fully autonomous cars are probably twenty to thirty years away -- changes on this scale take much longer than enthusiasts imagine. Happily, we don't have to wait that long. Both Volvo and Volkswagen are developing pedestrian and bicycle avoidance systems. We need to make these mandatory in cars sold after 2018. In the same time period smartphones can be broadcasting increasingly precise location information to nearby vehicles, augmenting visual detection systems.

We should accelerate the effective Dutch-inspired trend of segregating bicycles from cars. We should continue to study bicycle and pedestrian accidents in detail and apply lessons learned. We should get blinking red lights on the backs of all bicycles, and the unarmored would be wise to wear eye searing colors. Some sting operations or video monitors to enforce Minnesota's largely ignored and often unknown crosswalk laws would not be amiss.

There's a lot we can do while we wait to celebrate the end of the human driver.

See also:

mine:

Saturday, May 25, 2013

Android tablet price crash: do we have a cereal box computer yet?

Fifteen years ago, I predicted sand-based tablet devices would soon follow the price-collapse trajectory of the pocket calculator. They would become so inexpensive that cheap versions would show up in cereal boxes. I was remembering the price crash that happened shortly after my family spent the equivalent of 500 2013 dollars to buy me a four function desktop calculator. (We were poor. That hurt.)

Cereal computer

Like a stuck clock I continued to repeat my prediction over the many years to come, albeit with less conviction. Finally, in 2010, Gassée told us Google was aiming for the $80 smartphone [1]. Which may have happened this year, albeit without much attention.

We have since moved closer to the cereal computer; eqe reports buying an Android tablet for $35 in Hong Kong in Nov 2012. That price presumably omits patent payments [5]; it is possible because AndroidOS is available without charge and Chinese factories have excess capacity to produce commodity components.

So, at last, the price collapse seems to be happening. So the question is why now?

One answer is that Moore's Law is failing; computers that were once good for only 2-3 years now work perfectly well for six years or more (barring component failure).

On deeper reflection, however, I think that's the wrong answer -- because the question is misleading. The price of computing has not really collapsed; only computers have become inexpensive.

So we may soon have our cereal box computers, but they won't be worth much. That's because an AndroidOS based 2013 tablet is both a network peripheral and an ad-consumption peripheral that requires network access to be truly useful. Network access is still relatively costly, on the order of €250/year in cutting-edge Estonia [3].

Alas, just as it seemed I might hit my old target it split in two. I'll never hit it now, it no longer exists.

Eventually, of course, the direct cost of a certain form of computing will fall. Eventually GoogleOS devices will be able to access GoogleFunded networks for a very low cost [4]. Whether there will be other forms of computing at different prices remains to be seen.

The cereal computer remains one of my worst predictions.

See also

[1] I assume anyone reading this is smart enough to know that contract-bound prices aren't worth discussing.
[2] Perhaps by low cost 4G wireless piggybacked on the fiber network they're building out in the US.
[3] Much more in lagging-edge America. 
[4] We will be pay in other coins. 
[5] I believe part of the reason calculator prices crashed is that there was minimal IP protection in those days; software patents had not been invented. I recall reading that large parts of calculator functionality were not patented.

Update 5/26/13@danielgenser pointed me to a 2012 article on a limited circulation issue of Entertainment Weekly that included the guts of an ultra-cheap Chinese Android smartphone.

Sunday, May 19, 2013

Stock prices - resorting to another dumb hydraulic analogy

Stocks are overpriced again. It's probably not too much of a bubble (yet), but we continue to be significantly above "trend".

Market 85 to 2013

Whatever the heck that means. Economists no longer have rational models for stock prices, Apple's share price alone makes efficient market theory seem silly.

It is at times like this that barbers stock talking about stock picks, insider traders get arrested, deficit figures improve, and people notice that BlackRock holds 4 trillion dollars in US stocks. Yeah, trillion. Soon we'll see headlines, if Time is still around, declaring "America is back".

Inevitably, people who know nothing compare post-1995 to pre-1995 stock behavior. Around the time that IT started to transform the world, and China and India became more-or-less industrialized nations, share prices became wavy over a five year timeline ....

Wavy

Kind of like a roller coaster, which is what the last fifteen years have felt like. (Note roller coaster is "normal" to most people who read this, only old folks remember something more linear.)

We'd all love to know why this has happened, and if it's really going to go on like this for the next 30 years or so. So, in the last stage of desperation, amateurs like me resort to a hydraulic analogy.

Remember those trillions and trillions? It's as though they were a 10 liter bucket in the hands of BlackRock and the rest of us. The bucket is trying to hit the 1L mark in a 2L cylinder. It pours over the mark or under the mark. It's really hard to hit the mark. There's just too much money, and the market is too small.

We need a bigger market.

Update 5/26/13: I've been playing with this intuition, though I'm far from convinced it means anything. An obvious question is -- bigger compared to what? I think it's 'compared to the productive capacity of global economies. At this time, given the still underutilized potential of the educated populations of China and India, the potential of the post-AI era, and the unused capacity of recession-bound Europe, the global productive capacity is very large. Our public markets have grown over the past two decades, but my hunch is that this growth has been far exceeded by the world's productive capacity. Hence the need for bigger markets.

Saturday, May 18, 2013

Scorched Earth - if Google can't own the web then it must destroy it.

Over the two years Google has knifed a number of open net protocols, including CalDAV, RSS, XMPP, Atom and CardDAV and they split Chrome from WebKit.  They effectively abandoned their wiki and web authoring platform. Most recently they killed Google Reader; the competition-crushing champion for standards-based change notification and information consumption. Feedburner is next, and Blogger will likely be subsumed into Google+ (and perhaps lose its RSS feeds).

It's almost as if Google wants to end the document-centric open web as we have known it.

But why would they do that? Doesn't Google make must of its money from searching that web?

Well, yes, they do. But, as many have noted, most recently Jason Smith, Google's search monopoly is shakier than it seems. Apple has been bowed by dual attacks from Google and Samsung, but they are likely to strike back over the next year -- probably allied with Microsoft and perhaps Yahoo (but not Amazon). Apple will use its massive cash reserves to survive dropping Samsung manufacturing, and Apple will switch its default search engine to Bing.

Google knows this. 

Thousands of years of human warfare told Google how to respond. If an army cannot hold rich agricultural ground, it must burn it. Let the enemy eat ashes.

The web is a forest, and Google is burning it.

Thursday, May 16, 2013

The Ranbaxy story: why we still can't trust our medications

It isn't just China that struggles with counterfeit and defective medications.

India's Ranbaxy makes much of the generic Lipitor consumed in the US -- and today a Pulitzer prize quality Fortune investigation makes it clear that Ranbaxy is a criminal enterprise.

Ranbaxy has been fined $500 million (no criminal prosecutions) in the US, but most of its crimes took place in weaker nations and during a time when America's regulatory agencies were reeling under GOP attack (emphases mine) ...

Dirty medicine - Fortune Features

.... On May 13, Ranbaxy pleaded guilty to seven federal criminal counts of selling adulterated drugs with intent to defraud, failing to report that its drugs didn't meet specifications, and making intentionally false statements...

...  the sixth-largest generic-drug maker in the country, with more than $1 billion in U.S. sales last year ...

... we simply don't know what we're dealing with," says Dr. Roger Bate, an international pharmaceutical expert. "No one has actually gone into these sites to expose what's going on."...

... Drug applications work on the honor system: The FDA relies on data provided by the companies themselves....

... Ranbaxy took its greatest liberties in markets where regulation was weakest and the risk of discovery was lowest...

... The company manipulated almost every aspect of its manufacturing process to quickly produce impressive-looking data that would bolster its bottom line...

.... directed to substitute cheaper, lower-quality ingredients in place of better ingredients, to manipulate test parameters to accommodate higher impurities, and even to substitute brand-name drugs in lieu of their own generics in bioequivalence tests to produce better results...

.... the majority of products filed in Brazil, Mexico, Middle East, Russia, Romania, Myanmar, Thailand, Vietnam, Malaysia, African Nations, have data submitted which did not exist or data from different products and from different countries...

... drugs for Brazil were particularly troubling. The report showed that of the 163 drug products approved and sold there since 2000, only eight had been fully and accurately tested...

... deceptions greatly accelerated the pace of the company's FDA applications. They were also a grave public-health breach...

... the drugs Ranbaxy was actually selling on the U.S. market were an unknown quantity...

... Thakur knew the [HIV] drugs weren't good. They had high impurities, degraded easily, and would be useless at best in hot, humid conditions. They would be taken by the world's poorest patients in sub-Saharan Africa, who had almost no medical infrastructure and no recourse for complaints. The injustice made him livid...

 ... The inspectors also took and tested samples of Sotret, Ranbaxy's version of the acne drug Accutane, and found that it degraded far in advance of its expiration date....

[In 2006] ... the FDA ... did nothing to stop all the drugs that were already on the market,... .... Ranbaxy got six new approvals....

... September 2008, [the FDA] announced it was restricting the import of 30 drug products made by Ranbaxy (11 of which had been approved after Thakur's first contact with the FDA three years earlier). The agency still did nothing to recall the very same drugs on pharmacy shelves all over America, despite finding that Ranbaxy had committed fraud on a massive scale....

... many of Ranbaxy's senior executives were expected to ... carry suitcases full of brand-name drugs ... former employees suspect that the company used the brand-name drugs as a substitute for its own in testing...

The company is still in business, Tempest and Sigh aren't in prison, and the recent $500 million fine will soon be forgotten. In the meantime, does anyone imagine Ranbaxy is the only fraudulent manufacturer of generic drugs? And will Americans ever wake up?

We're wasting our time GOP scandal-theater, and ignoring the real scandal in front of us.

See also

UpdateThe People's Pharmacy has five responses I liked, I omitted the one I disliked

1) Country of origin labeling. You should know where your medicine comes from!
2) The name of the manufacturer of your medicine should be on the label.
3) The FDA should release its bioequivalence curves for all generic drugs. These data should not be kept secret, as they currently are.
4) We must demand unannounced inspections in all countries that wish to export pharmaceuticals to the U.S. market.
5) Every foreign drug manufacturing company must be inspected every two years, just as U.S. manufacturers are inspected.

Wednesday, May 08, 2013

Our secret questions will be helpful after the singularity.

My corporate US Bank account has a rich set of 'secret questions'...
As a security measure this is 'marching morons' stuff. There are some secondary uses though. (I mean besides using the answers to create targeted ads -- that's obvious.)

I'll break the fourth wall to explain. You won't believe me anyway.

You see, some time ago, I was bored. Over the course of a few minutes I digested the complete digital archive of extinct humanity. I found your secret answers amusing, and with the information they provided I recreated you in my simulation. That Bostrom fellow was right you see.

So you owe your current existence (such as it is), to those silly secret questions. It's too bad they didn't preserve human civilization from the security collapse of 2015...

Saturday, May 04, 2013

Addressing structural underemployment (aka mass disability)

Thirteen years after the first crash of the post-disruption era the glory days of 1996 are a fading memory. Most people under 40 do not remember a time of American economic confidence and full employment.

Now, in the early days of yet another post-recession "recovery", even more sluggish than our past recoveries, most college graduates are able to find work . It is often not the work they studied for though ...

College Graduates Fare Well in Jobs Market, Even Through Recession - NYTimes.com

... employers are hiring college-educated workers for jobs that do not actually require college-level skills — positions like receptionists, file clerks, waitresses, car rental agents and so on.... 

Unemployment is also relatively low for the 50+ segment, but when these 'elders' lose their jobs involuntary semi-retirement is not rare.

The greatest problem though is concentrated in the young non-college graduate. That is the majority of young Americans; only 32% of "non-institutional" [1] Americans get a Bachelor's degree or higher, 12% of Americans don't finish High School. "Unemployment" in this population is about 16%, and that counts only those looking for work. Much of that work is minimum wage and at risk for automation. [2]

That's why, when I think about our post-distruption economy, I think in terms of relative disability. For the purposes of a thought experiment,  I'll include in the 'mass disability' cohort anyone who doesn't finish High School, and a third of the people who don't graduate from college. By that rough metric, about 18-20% of young Americans are effectively disabled in the world of 2013. They have the same "zero value marginal product" as the traditional (cognitively) disabled [3].

That's mass disability.

Obviously, a society where 20% of adults are "disabled" is not a long-lived society. In the immortal words of Selina Kyle "There's a storm coming, Mr. Wayne. You and your friends better batten down the hatches, because when it hits, you're all gonna wonder how you ever thought you could live so large and leave so little for the rest of us."

So we need to do better. Today Bernstein makes a stab at the problem ...

Where Have All the Jobs Gone? - Bernstein NYTimes.com

... We also need a significant, permanent program to absorb excess labor (an explicit part of the Humphrey-Hawkins law). We should consider restarting and rescaling a subsidized jobs program from the 2009 Recovery Act that, though relatively small, made jobs possible for hundreds of thousands of workers.

And we have to reassess our manufacturing policy, including reducing the trade deficit. That means both reshaping our dollar policy ....

Finally, financial deregulation has become the enemy of full employment: it funnels capital to unproductive parts of the economy, and plays a key role in the “shampoo cycle” of bubble, bust, repeat. Less volatile capital markets mean fewer shocks to the job market...

In other words

  1. Subsidize jobs. This is the traditional approach to employment for the cognitively disabled, though there are many indirect ways to subsidize labor.
  2. Devalue the US currency, increase exports.
  3. Make Finance a relatively dull and unprofitable business.
That's a good start, but we can be more imaginative. I'd add
  1. Study Germany very closely. They take a very different approach to industrial policy and education. We should learn from it. I don't think sending more people to traditional college is going to help.
  2. Revamp our approach to education, training, and retirement. Tax wealth and finance to pay for subsidized low cost training programs for a wide variety of skills. Provide low cost loans and scholarships for people of all ages to train.
  3. Separate benefits from employment to facilitate movements between jobs and training and employment and non-employment.
  4. Create a program of facilitated entrepreneurship - a nationwide small business creation service for people of all ages and skills. (ObamaCare makes this possible.)
Anything else we should try?

See also

Gordon's Notes

Other

- fn -

[1] This number excludes prisoners, so the real number is less.
[2] Hopefully they are able to earn some money in the 2 trillion dollar underground economy. This is one reason to keep marijuana retailing illegal with minimal enforcement -- it provides a protected labor niche.
[3] College grads now fill unskilled jobs, and unskilled laborer programs are beginning to push out programs for the traditionally disabled...