Every three years I have to do a quality improvement project to maintain my family medicine board status. This year I decided to focus on my patients with moderate chronic kidney disease. I have access to a report that identifies the patients of interest so all I need to do for the project is upgrade their care.
To do that I had to put together a list of things to do by reading the short "pocket card" version of the VA/DoD care guidelines (I'm too lazy to read the entire long thing). I then ran it past a friend who is a leading research nephrologist to comment on which of the guideline actions were really valuable.
I liked the result so much I'll share it here. The numbered items are what I took from the guidelines, the comments in () are his corrections, the comments in [] are my later thoughts. I think it's most interesting to read with both, I added emphases:
As of Dec 2020:
1. Measure urine alb/cr ratio yearly (sure in people with diabetes not on ace/arb)
2. Measure Cr yearly (ok- not great evidence) [U/A, micro albumin, Iron]
3. ACE/ARB for all but not both (if htn and/or microalbuminuria – or chf) [so implies measure for microalbuminuria along with yearly Cr]
4. Oral iron therapy (if iron deficient, or starting epo) [so, contra guideline, not routinely, but implies check iron yearly?]
5. If Hgb < 10 consult for erythropoietin (I’d wait till < 9 – no evidence for greater)
6. DM
a. Evaluate metform if CrCl < 40 (ok)
b. SGLT-2 (empagiflozin, etc) inhibitor if stage 1-3 and DM (can go down to egfr of 30)
c. GPL-1 agonist (liraglutide) (no good evidence beyond sglt2) [contra guideline]
7. If GFR < 60 then BP < 140/90 (I think this would be for most people)
8. Do cystatin-C GFR one time (never unless paraplegic or loss of muscle mass – amputation) [contra guideline]
9. If not Diabetic need at least one renal imaging study [I made this one up, but seemed to follow] (sure)
10. Apply Kidney Failure Risk Calculator (Navdeep Tangri, MDCalc) (sure)
11. Stage 3 and above: dietary consult
a. Bicarbonate supplementation if metabolic acidosis (if bicarb < 18)
b. Dietary sodium restrictions (yes – for all those with htn)
c. Protein 0.6-0.8 g/kg/day (skip this one – good evidence – hard to do) [Curbsiders had recent podcast saying same]
12. Stage 3 and above need a PTH measured (never measure pth in ckd unless hypercalcemia) [contra pocket card guideline so many a mistake in that]